Cyclotron F-18 synthesis, Ga-68 generator chemistry, theranostic radionuclide production logistics. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Gaia Dellepiane, Lars Eggimann, Alexander Gottstein, Samuel Juillerat et al.
The theranostic pair 133La/135La has recently attracted growing interest as a promising candidate for combined diagnostic and therapeutic applications, owing to the favorable nuclear and chemical properties of lanthanum. 135La (t1/2 = 18.91 h) decays by electron capture (EC) to the ground state of 135Ba, emitting Auger cascade electrons that are potentially useful for targeted …
J. Kowalczyk, Klaus Abraham, Christina August, Runa S. Boeddinghaus et al.
To review recent advances in research on per- and polyfluoroalkyl substances (PFAS) and outline priority steps for risk assessment in consumer health protection, the German Federal Institute for Risk Assessment (BfR) organized the 'International PFAS Conference' in Berlin in October 2025. Building on the European Food Safety Authority's (EFSA) opinion in 2020, global research a…
A generalization of the method of exact solutions of quantum equations for particle wave functions is discussed, aimed at describing particle interaction processes in the presence of electromagnetic fields (the Furry representation of quantum electrodynamics), extended to the case of processes in an external medium.Exact solutions of the Dirac equation for neutrinos in stationa…
Yamanappa Hunashal, Suma Gopinadhan, Raihanah Harion, Fathima S. Refai et al.
Background: Natural compounds from avocado fruit (avocadene, avocadyne, and acetate derivatives) exhibit notable biological activity, although their molecular mechanisms remain unclear. The avocado-derived lipids exert potent nematocidal activity against several parasitic nematodes. In Caenorhabditis elegans (C. elegans), those compounds caused concentration-dependent toxicity,…
We show that accounting for a non-instantaneous reheating phase after inflation can significantly modify the charged lepton Yukawa equilibration temperature in the early Universe. This finding calls for revisiting the role of lepton flavors in leptogenesis models where right-handed neutrinos are produced and decay during the extended reheating period. Our analysis reveals that …
Qiaohui Wang, Yi-Fan Liu, Biao Wang, Qin Xiao et al.
Abstract Water droplets entrapped in crude oil have recently been recognized as unexpected but metabolically active microbial habitats in shale oil reservoirs. However, the key environmental drivers that shape the community composition and metabolic profiles of these droplet microorganisms remain poorly understood. Here, we investigated three shale oil samples from Jiangsu oilf…
Francesca Sacco, Fabio Baroni, Angela Capolupo, Sofia Petrocchi et al.
Recombinant biomacromolecules have significantly transformed pharmaceuticals, in particular monoclonal antibodies (mAbs) that target key areas in oncology, immunology, inflammation, and neurodegenerative diseases. Developing biotherapeutics requires a detailed understanding of their biological properties. This, in turn, brings about the importance of characterizing higher-order…
Traditional solid-state physics treats the hole as a mathematical abstraction—a vacant state at the top of a valence band assigned an effective mass mh* purely to balance transport equations—without offering a physical mechanism for why this mass spans more than an order of magnitude across elemental lattices. Extending a classical topological model of pair production—where ele…
Lijuan Li, Hongmei Xu, Xin Zhang, Qiyuan Wang et al.
Abstract. Controlled gasoline tailpipe profiles may not fully represent traffic particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) under real road conditions. The molecular compositions of tunnel and controlled tailpipe PM2.5 were compared using high-resolution mass spectrometry. Formulas common to both profiles were concentrated at low m/z and low to intermediate car…
Emir Husain, Vedang Kore, Dev Patel, C. A. Rishikeshan et al.
We introduce the Circular Loop Data Model (CLDM), a lightweight data model and domain-specific language (DSL) for embedded, offline-first applications and rapid prototyping. CLDM organises application state as named loops of parallel string-valued segments, persisted in a single BSON file with file-level locking for cross-process concurrency. The DSL exposes six core commands (…
RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and …
Roya Ahemeh, R. Akbari, L. J. Azevedo, W. Bertsche et al.
Abstract Precision measurements of the fundamental properties of trapped antihydrogen in the ALPHA experiment at CERN require an accurate determination of the antihydrogen energy distribution. We introduce a new diagnostic technique, termed Spatio-Temporal Annihilation Mapping (STAM), which measures this distribution by exploiting the dynamics of antihydrogen in adiabatically t…
Saruta M, Shiroki R, Takeuchi A, Yoshizawa A et al.
Abstract Objectives This study evaluated the feasibility and safety of 68 Ga-PSMA-11 PET/CT using an in-house cyclotron-produced 68 Ga in patients with prostate cancer. Methods We prospectively included 10 patients across clinically relevant disease settings: biochemical recurrence after definitive local therapy, non-metastatic castration-resistant prostate cancer, and metastat…
Shujie Hu, Yuan Liu, Jiao Tang, Chengshuai Liu et al.
Wildfires release substantial dissolved black carbon into surface waters, often coinciding with elevated yet poorly explained levels of organosulfate-like dissolved organic sulfur in rivers. Here we show that wildfire-derived dissolved black carbon promotes light-driven sulfur transformation in dilute, near-neutral freshwaters. Electron paramagnetic resonance reveals sulfate-as…
Dissolved black carbon (DBC) serves as a crucial electron shuttle in various biogeochemical cycles owing to its highly mobile and redox-active nature. Prior work on DBC electron-shuttling has focused on thermodynamic metrics—electron donating capacity (EDC) and electron accepting capacity (EAC)—which quantify total potential for electron exchange. Those metrics, however, do not…
Gautam D, Chaturvedi S, Shashikant, Chaudhary R et al.
We report a novel 5HT1A receptor-targeted multimodal imaging probe developed by functionalizing biocompatible nitrogen doped carbon quantum dots (CDMPP-DTPA). The carbon quantum dots were hydrothermally synthesized using methoxyphenyl piperazine (MPP) for neuro receptor targeting and diethylenetriaminepentaacetic acid (DTPA) for metal chelation. Subsequent loading with Gd3+ and…
A. Sleiman, F. Vianna Legros, K. Lalanne, M. Cardot-Martin et al.
Proton therapy is increasingly used, due to its favourable physical properties such as the Bragg peak, which enable precise dose deposition while minimizing exposure to surrounding healthy tissues. One of the main indications for proton therapy is head and neck tumours. In addition to their therapeutic relevance, protons are also a key component of space radiation spectrum, rai…
Xiao‐San Luo, Xun Wang, Qingyou Liu, Yin Ye et al.
Electroactive microorganisms play important roles in extracellular electron transfer and soil carbon cycling. However, their effects on the molecular transformation of dissolved organic matter (DOM) in paddy soils remain poorly understood. Here, a bioelectrochemical system (BES) was used to enrich electroactive microorganisms from paddy soil, and DOM molecular transformation to…
Shasha Huang, Zhenxing Shen, Cailan Li, He Shen et al.
Abstract. Animal dung was widely used for rural heating and cooking on the Qinghai-Tibet Plateau (QTP), its contributions to climate-relevant and health-related aerosol properties remain poorly understood. In this study, water-soluble organic matter (WSOM), which separated into neutral humic-like substances (HULIS-n), acidic humic-like substances (HULIS-a), and highly polar WSO…
Diagnostic reference levels (DRLs) for positron emission tomography (PET/CT) examinations have not previously been established in Costa Rica, and data from Central America remain limited due to the restricted availability of PET/CT systems in the region. This study established local DRLs for administered 18F-FDG activity and CT dose metrics in 393 adult lymphoma patients underg…
Kendall E. Barrett, Jason C. Mixdorf, Alan McMillan, Eduardo Aluicio‐Sarduy et al.
Calcium influx is a fundamental component of neuronal signaling and is markedly altered during neuropathic pain. Voltage-gated calcium channels (VGCCs) play a central role in nociceptive transmission; however, multiple calcium-permeable pathways contribute to calcium-associated neural activity. Because Mn 2+ shares similar ionic properties and cellular transport mechanisms with…
Adrien Holzgreve, Sophie C. Siegmund, Liam Widjaja, Rudolf A. Werner
management of patients with advanced prostate cancer, firmly anchored in clinical guidelines [8].This article provides an update on established PSMA theranostics using beta-emitting ligands, based on major clinical trial results.It then continues with an overview of more recent developments in the field of PSMA radiotheranostics, focusing on alpha-based approaches, in particula…
Muzzioli R, Pisaneschi F, Gammon ST, Sutton MN et al.
Talazoparib (TZ) is a potent poly(ADP-ribose) polymerase 1/2 (PARP1/2) inhibitor that uniquely traps PARP complexes at sites of single-strand DNA damage thereby offering opportunities for targeted radioligand therapy. Radiolabeled halogenated TZ derivatives were synthesized using boronic ester precursors to enable incorporation of diagnostic and therapeutic radionuclides: 18F f…
Frequent algal blooms alter dissolved organic matter (DOM) dynamics and carbon sink functions in eutrophic lakes, yet how bloom type governs DOM molecular transformation and microbial carbon pump (MCP) direction remains unresolved. Integrating Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), metagenomics, Biolog EcoPlate, and incubation experiments, we i…
ObjectiveThis Phase I/IIa study evaluated the safety, pharmacokinetics, internal radiation dosimetry, and image quality of cyclotron-produced ⁶⁸Ga-PSMA-11 synthesized using an automated module in a Japanese population.MethodsIn this single-center trial, nine Japanese men (3 healthy volunteers, 6 prostate cancer patients) received a single intravenous injection of ⁶⁸Ga-PSMA-11 (…
The commissioning of medical cyclotrons necessitates a thorough assessment of radioactive waste management systems, operational protocols, and radiological safety. Significant neutron and gamma radiation is generated during cyclotron operation for radionuclide production, which are frequently employed in positron emission tomography (PET) for clinical diagnosis and biological r…
Mégnin-Chanet F, Laurans M, Maia-Leite A, Laurent C et al.
BackgroundProton therapy (PT), first delivered passively using the Double Scattering (DS) technique, has shifted to active delivery through the Pencil Beam technique (PBS). However, the biological effectiveness of DS versus PBS proton beams on cancer cells, remain largely unknown. Given that PBS-PT is now commonly used to treat young patients with Ewing sarcoma, this point is o…
We demonstrate a wavelength-selective atmospheric-pressure laser ionisation (APLI) workflow for direct inlet probe (DIP) evolved-gas analysis with ultra-high-resolution mass spectrometric detection. A tuneable optical parametric oscillator (213, 225, 248 and 266 nm) was integrated into a modified atmospheric-pressure ion source and coupled to Fourier-transform ion cyclotron res…
RationaleCarbon-carbon double bonds are ubiquitous structural motifs in natural products and pose a key challenge in locating their presence in analytes via MS-based methods. Here, we use the alkaloid reserpine as a model system to examine whether OAD reactions can locate quaternary double bonds embedded in fused multicyclic structures.MethodsOAD reactions were carried out on t…
Genome sequencing is the gold standard for microbial identification. However, it fails to distinguish closely related species with overlapping genetic features. This is the case of Bacillus cereus and Bacillus cytotoxicus, two members of the B. cereus group with distinct pathogenic profiles. While B. cereus, a well-known opportunistic pathogen involved in intestinal and extrain…
Moreno-Pedraza A, Gorman B, Velickovic M, Bentelspacher M et al.
Mass spectrometry imaging (MSI) represents an exceptional tool for exploring complex biological systems spatially at the molecular level. However, its multidimensional nature and large data outputs make it challenging to extract meaningful biological insights. Advancements such as the METASPACE platform allow researchers to efficiently process, annotate, and interpret MSI datas…
BackgroundDespite the remarkable sparing of normal tissue by FLASH radiotherapy, the fundamental mechanisms that link physics to biological outcomes remain unclear. Among water radiolysis species produced after irradiation, hydrogen peroxide ( H2O2${{{\mathrm{H}}}_2}{{{\mathrm{O}}}_2}$ ) is a final product resulting from hydroxyl radical ( OH•)${\mathrm{O}}{{{\mathrm{H}}}^ \bul…
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