Authorised Indian Distributor
Saxsons Group
New Delhi, India · Since 1997
Cyclotron-grade [18O]H₂O target water for F-18 production via the ¹⁸O(p,n)¹⁸F reaction. Isotopic enrichment 98–99 % atom O-18, chemical purity > 99.99 %, conductivity < 3.0 µS/cm, sterile and pyrogen-free (< 0.25 EU/mL), pH 6.0–8.0. Supplied in sealed crimp-cap glass vials with chlorobutyl rubber septum, sterilised prior to filling. Per-batch certificate of analysis covering isotopic, chemical, sterility and ionic-impurity testing. Cold-chain delivery across India.
| Isotopic composition | O-18 ≥ 98 % atom (typical 98.5–99.0 %); O-17 < 3.0 % atom; O-16 < 3.0 % atom |
| Chemical purity | > 99.99 % m/m; normalised with respect to hydrogen isotope distribution |
| Electrical conductivity | < 3.0 µS/cm |
| pH | 6.0–8.0 |
| Total organic carbon | < 2.0 mg/L (typical < 1.0 mg/L) |
| Pyrogen (LAL) | < 0.25 EU/mL |
| Sterility | Per-batch sterility-tested; sealed bottles sterilised prior to filling |
| Halide panel | F⁻, Cl⁻, Br⁻, I⁻ all ND (each < 0.1 mg/L) |
| Metal panel | Ca, Mg, Na, K, Cu, Fe, Zn all ND (each per panel limit, typically < 0.05 mg/L) |
| Anion panel | PO₄³⁻, NO₃⁻, SO₄²⁻, NH₄⁺ all ND |
| Packaging | Glass vial with chlorobutyl rubber septum, crimp-sealed; 50 g / vial typical (other fills by lot agreement) |
| Shelf life | Typically 24 months from manufacture under specified storage |
| Compliance framework | AERB cyclotron-facility consumable; CDSCO import licence; per-lot CoA |
The cyclotron consumable that gates every F-18 batch downstream
The default target water for [18F]FDG synthesis — the F-18 from 98–99 % O-18 water feeds the FDG synthesis module with the activity profile FDG-grade kits expect. Higher enrichment means higher per-shot F-18 activity for the same beam time.
F-18 production for [18F]NaF skeletal-imaging tracer. NaF formulation is a downstream radiochemistry step from the same target water — same isotopic spec, same vial spec.
F-18 production for emerging clinical tracers — [18F]PSMA-1007, [18F]Flutemetamol, [18F]Florbetapir and [18F]choline. High-enrichment target water gives sharper per-shot activity for the small-volume target-loading workflow these tracers use.
IIP F-18 labelling and method-development workflows — same target water, same isotopic spec. The CoA serves as the input-material qualification record for the investigator protocol.
After F-18 elution, the post-irradiation target water can be ion-exchanged + concentrated for re-use. Higher-enrichment input water means higher-enrichment recovered water — supports closed-loop O-18 water economics for high-volume sites.
On a new target body or after a target rebuild, the target validation run uses certified-spec water — eliminates the input-material variable when characterising target performance.
The 18O(p,n)18F cross section scales with the O-18 atom fraction. Moving from 95–97 % entry-grade water to 98–99 % cyclotron-grade gives a measurable per-shot activity boost — same beam time, more F-18 at end-of-bombardment, more patient doses per batch.
Ionic impurities in target water co-irradiate with the O-18 and produce parasitic radionuclides (Na-22 from Na, Co-58 from target-body contact). The < 3.0 µS/cm conductivity spec gates the input material below the threshold where these by-products show up on the QC gamma spectrum.
Per-batch certificate of analysis is the input-material qualification record for the cyclotron GMP file. AERB inspection of a PET radiopharmacy reads the CoA chain; cold-chain delivery preserves the chain from manufacture to target loading.
IAEA + AERB references that anchor cyclotron target-material qualification. Contact Saxsons for India pricing, per-lot CoA review and cold-chain delivery scheduling.
IAEA technical report on cyclotron-produced radionuclides including target-material specifications and F-18 production chemistry.
IAEA technical report covering PET radiopharmacy QC including input-material qualification expectations.
Indian regulatory framework for medical cyclotron facility licensing including consumable qualification expectations.
O-18 Enriched Water
Each card opens a focused post for a specific specialty — peer-reviewed evidence and clinical workflow, written for the persona you select.
Contact Saxsons Group for O-18 enriched water supply, per-lot CoA review, AERB / CDSCO import paperwork and cold-chain delivery scheduling across India.