A retrospective comparative evaluation of rectal preparation strategies for patients undergoing stereotactic body radiotherapy for prostate cancer.

Abstract

ObjectivesWe performed a retrospective study comparing 2 rectal preparation regimens, Polyethylene Glycol 3350 (PEG) and Fleet Enema (FE), in patients undergoing prostate stereotactic body radiation therapy (SBRT).MethodsThe study included 24 patients receiving prostate SBRT (40 Gy in 5 fractions), for a total of 120 treatment fractions. Patients received either FE (N = 73) or PEG (N = 47) for rectal preparation. Outcomes included: (1) treatment time, measured from the initial setup cone-beam CT (CBCT) to the post-treatment CBCT (including rectal-related interventions, excluding machine delays); (2) intra-fraction motion, defined as the displacement vector between verification and post-treatment CBCTs registered to fiducial markers; and (3) clinical acceptability, determined by blinded review of all setup CBCTs by 3 radiation therapists (RTs), who scored each scan as either "Acceptable" (proceed directly to treatment) or "Need Intervention." Regression analysis was used to compare regimens.ResultsPopulation-averaged median treatment times were 14 minutes (95% CI, 5.8-22.2) for PEG and 11 minutes (95% CI, 9.6-12.3) for FE, with greater time variability in PEG (P ConclusionsOverall, the FE regimen showed greater consistency in all outcome measures. This suggests an operational advantage for using FE since it results in more consistent patient treatment times without negatively impacting treatment quality and precision.Advances in knowledgeDaily FE improves the consistency of prostate SBRT treatment and enhances the clinical workflow by minimizing unplanned disruptions.