SBRT outcomes + protocol updates — per-site evidence for lung, liver, prostate, pancreas, spine, oligomets. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Objective To evaluate the dosimetric and delivery-time effects of Jaw width, Pitch, and modulation factor (MF) in Radixact TomoHelical planning across different anatomical scenarios, and to develop anatomy-stratified practical guidance for parameter selection. Methods Eighty cases were stratified into four anatomical groups according to target length, geometric complexity, and …
Kaczynska A, Jin F, Stewart M, Kipritidis J et al.
Objective.Real-time six-degree-of-freedom (6DoF) tumour motion monitoring is important for accurate stereotactic body radiotherapy (SBRT) of thoracic and abdominal cancer sites, yet existing approaches either require specialised imaging hardware or continuous fluoroscopic imaging. This study presents the development and first experimental implementation of a real-time image-gui…
BACKGROUND: Patient-Specific Quality Assurance (PSQA) for Elekta Unity MR-Linac treatments delivered under Comprehensive Motion Management (CMM) is challenging because beam gating, unexpected interruptions, and split sub-segments introduce delivery complexities that are not fully addressed by conventional quality assurance workflows. PURPOSE: This study aimed to develop and eva…
Taoran Li, Esa Kuusela, Emmi Ruokokoski, H. Hyvonen et al.
BACKGROUND: Conventional VMAT optimization largely treats delivery time and deliverability as emergent properties of simplified, control-point-centric models that often ignore finite acceleration and other dynamic limits. As modern linacs continue to increase maximum axis speeds and dose rates, there is a growing need for a planning paradigm that makes the plan quality-time tra…
Adenosine is a central metabolic regulator of tumor immune escape, shaping the tumor microenvironment (TME) through suppression of effector lymphocytes and reprogramming of myeloid populations. Extracellular adenosine is generated primarily via the ectonucleotidases CD39 and CD73 and signals through A2A (A2AR) and A2B (A2BR) receptors on T cells, NK cells, tumor-associated macr…
Stereotactic ablative radiotherapy (SABR) is emerging as an alternative treatment for patients with locally recurrent prostate cancer after previous radiation. This approach allows for precise target coverage while limiting toxicity to surrounding organs. However, reported outcomes following re-irradiation of the prostate with SABR remain variable. This systematic review and me…
Karunya A S, K. Sudeep Kumara, Avin Kumar, Kamalaksh Shenoy
Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accou…
Abstract Proton therapy, an emerging radiation therapy technique, has gained significant attention owing to its unique physical properties and biological effects. This review aims to explore the impact of proton therapy on the tumor immune system and of its combination with other therapies. This review outlines the fundamental principles and oncological applications of proton t…
William Keustermans, Seppe Sels, Thomas De Kerf, Rhys Evans et al.
Accuracy evaluation of phase-shifting profilometry as a motion management add-on for intracranial stereotactic radiosurgery, Keustermans, William, Sels, Seppe, De Kerf, Thomas, Evans, Rhys Gustaf, de Freitas Nascimento, Luana, Hrsak, Hrvoje, Dolanski Babić, Sanja, Vanlanduit, Steve
Significant dose variations among cervical cancer patients with similar geometric characteristics may limit the effectiveness of knowledge-based planning (KBP) techniques that rely solely on geometric features for volumetric modulated arc therapy (VMAT) planning. To address this issue, this study adapts methodologies from prior research and proposes integrating dosimetric featu…
Recurrent hepatocellular carcinoma (HCC) adjacent to the heart is difficult to treat when surgery and conventional locoregional therapies are no longer feasible. We report an 87-year-old man with recurrent segment VIII HCC that remained viable after radiofrequency ablation, six sessions of transarterial embolization (TAE), and stereotactic body radiation therapy (SBRT). Followi…
Francesco Cuccia, Gianluca Mortellaro, Maria Campione, Vanessa Figlia et al.
Background The use of stereotactic body radiotherapy for primary and secondary lung lesions is well established. Although being supported by international guidelines, the application of single-fraction treatments is less reported in the literature. Methods We report a mono-institutional, retrospective analysis of inoperable patients with small lung lesions—including both primar…
Lung cancer remains a significant global health challenge, with radiotherapy serving as a cornerstone of treatment. However, the development of resistance to radiation therapy poses a major hurdle in effective disease management. In this study, we explore the novel role of MARCO, a gene involved in antimicrobial defense and cancer progression, in modulating the radiosensitivity…
PurposeRadiation-Induced Lymphocyte Depletion (RILD) varies substantially among patients and the extent to which different factors contribute to RILD remains incompletely understood. We present a model to predict time-dependent RILD for early-stage lung cancer patients treated with Stereotactic Body Radiation Therapy (SBRT) by simulating the lymphocyte circulation dynamics in b…
Stereotactic body radiotherapy (SBRT) is effective for localized prostate cancer, yet many recurrences originate from the intraprostatic tumor mass (ITM). Prostate-specific membrane antigen positron emission tomography (PSMA-PET) and multiparametric magnetic resonance imaging (mpMRI) enable precise ITM localization and support focal dose escalation. This trial assesses whether …
BackgroundStereotactic body radiotherapy (SBRT) is increasingly used for patients with oligometastatic prostate cancer, yet the optimal target definition, dose, and toxicity profile for rib metastases remain uncertain.ObjectivesWe assessed local control (LC), toxicity, and the risk of radiation-induced rib fracture (RF) after SBRT for rib metastases.DesignRetrospective multicen…
Siyang Huang, Songhua Yang, Yang Dong, Sheng Huang et al.
OBJECTIVE: This study proposes a 2π solid angle-based heuristic framework for non-coplanar volumetric modulated arc therapy (VMAT) in patients with multiple brain metastases (MBM) to automate treatment angle selection. Approach: Fifty-two patients with MBM (2-8 targets) were retrospectively included. A hybrid heuristic framework was constructed: first, a volume-weighted cumulat…
O. El mouden, H. Sekkat, A. Bannan, R. El Baydaoui et al.
Accurate characterization of the tissue–maximum ratio (TMR) is important for beam modelling and dosimetric verification, particularly for flattening-filter-free (FFF) beams and non-reference fields. This study characterized TMR for 6 MV flattened (FF) and FFF photon beams from an Elekta Versa HD across square fields from to . Central-axis water-phantom measurements using PTW mi…
Paula M. Novelli, Emmanuel E. Zervos, Amer H. Zureikat, Michael J. Pishvaian et al.
Abstract Purpose Localized intra-arterial delivery of gemcitabine (IAG) may provide advantages in terms of increased tissue concentration and decreased systemic dosing. We hypothesized IAG may result in decreased systemic gemcitabine concentration and associated side effects due to intracellular delivery prior to conversion to gemcitabine’s inactive metabolite, difluorodeoxyuri…
Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with a poor prognosis; conventional treatments provide limited durable benefit, and resistance commonly develops. The introduction of immune checkpoint inhibitors (ICIs) has expanded treatment options for TNBC; however, ICI monotherapy has demonstrated limited efficacy, particularly in patients with a…
Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy for solid tumors. RT acts as a potent immunomodulator, capable of functioning as an in situ vaccine through the induction of immunogenic cell death and activation of innate immune sensing, thereby promoting DC maturation and CD8+ T cell responses. However, RT also triggers counte…
Metastatic urothelial carcinoma (mUC) is traditionally managed with systemic therapy; however, long-term disease control remains uncommon despite advances such as immune checkpoint inhibitors and antibody-drug conjugates. Interest has grown in integrating metastasis-directed therapy (MDT), including metastasectomy and stereotactic body radiotherapy (SBRT), and primary-site trea…
A transition from the dose-to-water algorithm AAA to the dose-to-medium algorithm Acuros XB (AXB) presents challenges for comparison with measurements made in the dose-to-water calibrated ArcCHECK. This study evaluates the implications of this transition on patient-specific quality assurance (PSQA) measurements. A modified dose-medium calibration for the ArcCHECK to was introdu…
The treatment of prostate cancer with radiotherapy is evolving. How quickly radiotherapy can be delivered, and the relative risks and benefits of such a treatment, is of significant public interest. To determine whether stereotactic body radiotherapy (SBRT) was superior to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) in terms of patient-reported u…
In this article, we report a case of perineal recurrence of prostate cancer occurring 9 years after postoperative radiotherapy following radical prostatectomy for localized prostate cancer. We describe the use of stereotactic body radiotherapy as a potential ablative treatment. Pelvic magnetic resonance imaging identified an 8-mm lesion located below the penile root on the left…
PurposeThis multi-institutional phase I/II study evaluated the safety and efficacy of tremelimumab (T) and durvalumab (D) in combination with stereotactic body radiotherapy (SBRT) in oligometastatic head and neck squamous cell carcinoma (HNSCC) (ClinicalTrials.gov identifier: xxxxxx).MethodsPatients with oligometastatic HNSCC (2-10 lesions) received D (1500 mg) and T (75 mg) fo…
PurposeDespite decades of use, multiple prescription strategies continue to coexist in lung stereotactic body radiation therapy (SBRT). An accurate prescription should reflect the dose delivered throughout the breathing cycle with minimal bias and high precision. This study aimed to evaluate the accuracy of widely used lung SBRT dose prescription methods by assessing which meth…
Peer-ReviewedPubMedClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
Oligometastatic disease (OMD) and oligoprogression are clinically actionable states in which local treatment of limited tumour burden can prolong disease control for selected patients. Randomised phase II trials support metastasis-directed therapy (MDT), usually stereotactic body radiotherapy (SBRT/SABR), in several settings, but the effect is not uniform across tumour types. S…
PurposeThis guideline provides evidence-based recommendations on the use of radiation therapy (RT) for the treatment of pancreatic cancer in a variety of clinical settings including patients with resectable, borderline resectable, locally advanced, metastatic, and symptomatic disease.MethodsThe American Society for Radiation Oncology convened a multidisciplinary task force to a…
Background and purposeRib fracture is a recognized clinical complication in medically inoperable patients with non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy (SBRT), leading to diminished quality of life and delayed recovery. There remains an unmet need for reliable tools to predict rib fracture risk to support individualized prognosis. This study …
BackgroundTo date, no review has specifically focused on palliative-intent radiotherapy (RT) for pancreatic cancer (PC)-related pain. This study aimed to evaluate the pain response after palliative-intent RT for PC-related pain.MethodsA comprehensive literature search was conducted using PubMed, Ichushi-Web, and the Cochrane Library for studies published between 1971 and 2024. …
A 63-year-old man received a robotic left lateral sectionectomy for a 2 cm solitary segment (seg) 2/3 hepatocellular carcinoma (HCC). Pathology revealed clear margins without vascular invasion. Three years later patient received transarterial chemo-embolization (TACE) for suspected intrahepatic recurrence. However, follow-up computed tomography (CT) revealed solitary peritoneal…
Abstract Background Primary liver cancer (PLC) is a leading cause of global cancer mortality, with most patients diagnosed at unresectable stages. While locoregional and systemic therapies provide limited clinical benefit, evidence regarding stereotactic body radiotherapy (SBRT) in heavily pretreated, advanced-stage patients remains limited. This study aimed to evaluate the sho…
The purpose of this study is to explore whether spacer hydrogel morphology changes during the course of stereotactic body radiation therapy (SBRT) radiation to the prostate. A total of 198 patients at our institution each received spacer gel before SBRT on magnetic-resonance-guided linear accelerator (MR-Linac) between October 2023 and March 2025. Each patient received at least…
The aim of this study was to establish an optimal treatment strategy for functional liver-sparing radiotherapy by incorporating technetium-99 m galactosyl human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) into radiotherapy planning for recurrent hepatocellular carcinoma (rHCC). Three irradiation techniques-volumetric-modulated arc therapy (VMAT)…
To evaluate the dosimetric feasibility of combining stereotactic body radiotherapy (SBRT) for peripheral tumors with conventionally fractionated mediastinal lymph node (MLN) radiotherapy in small cell lung cancer (SCLC), with a focus on tumor-nodal spatial separation and geometry-dependent dose redistribution. A retrospective virtual planning study was conducted in 21 patients …
Peer-ReviewedPubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026
Pancreatic SBRT planning is challenging due to the proximity of highly sensitive organs at risk. Since automated planning is currently not available for the CyberKnife (CK) system, the optimization of high-quality treatment plans relies heavily on expert planners; however, even in this setting, the generation of suboptimal plans remains possible. The aim of this work was to dev…
Advances in systemic therapies and stereotactic body radiotherapy have profoundly modified the prognosis of patients with spinal metastases, increasing the need for surgical strategies that minimize morbidity while maintaining oncological efficacy. This narrative review aimed to summarize the current evidence concerning minimally invasive surgery, navigation, and robotic-assist…
Hypofractionated stereotactic body radiotherapy (SBRT) for pancreatic cancer has shown improved local control but is challenging due to the proximity of several organs at risk (OARs). This study investigated possible dosimetric variations over a simulated SBRT course for pancreatic cancer using daily MR images considering breath hold (BH) and internal target volume (ITV) motion…
Khalaji A, Ghazi F, Alivirdiloo V, Abosaoda MK et al.
Prostate cancer remains one of the most prevalent malignancies among men, necessitating effective radiotherapy strategies to improve patient outcomes. This review examines the current techniques employed in radiotherapy for prostate cancer, including external beam radiation therapy (EBRT), brachytherapy, and stereotactic body radiation therapy (SBRT). We analyze the clinical ou…
Samper Ots PM, González Santos D, González Del Portillo E, Valcárcel Díaz A et al.
IntroductionThe management of oligometastatic hormone-sensitive prostate cancer (omHSPC) has evolved with the introduction of androgen receptor pathway inhibitors (ARPi) and the increasing use of local therapies. However, evidence on the combined impact of systemic intensification and local treatment strategies in real-world settings remains limited.MethodsWe conducted a retros…
Peer-ReviewedPubMedClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
Zurita AJW, Vacas AI, Del Río HM, Jiménez MR et al.
PurposeTo evaluate whether principal component analysis (PCA) of rectal and bladder dose-volume histograms (DVHs) identifies dose regions associated with late toxicity after prostate stereotactic body radiotherapy (SBRT).Methods/patientsThis retrospective single-institution study included 106 patients with linked clinical and dosimetric data after prostate SBRT to 36.25 Gy in f…
BackgroundLattice radiotherapy (LRT) is a spatially fractionated technique that delivers three-dimensional high-dose vertices within tumors. However, conventional LRT is constrained by geometric limitations when applied to small and medium-sized tumor volumes, primarily due to the large beam sizes that restrict optimal lattice pattern formation.PurposeThis study aims to investi…
Nukushina A, Yamada R, Yoshimura T, Katoh N et al.
BackgroundCone-beam computed tomography (CBCT) is widely used in image-guided radiotherapy because it reflects the patient's anatomy immediately before treatment. However, CBCT images of the abdominal organs, including the pancreas, are often degraded by respiratory motion.PurposeTo address this limitation, this study quantitatively evaluated expiratory-phase CBCT (EP-CBCT), an…
Atalar B, Atahan C, Lock M, Cardarelli Leite L et al.
Localized treatment of oligometastatic liver disease can improve both local control and survival. The liver is a frequent site of metastases from colorectal, breast, and lung cancers, but most patients are not eligible for surgical resection due to lesion number, location, or comorbidities. For these patients, non-surgical ablative methods such as radiofrequency ablation (RFA) …
Primary liver and biliary tract cancers remain major causes of global cancer mortality, with liver and intrahepatic bile duct cancers accounting for 866,136 new cases and 758,725 deaths worldwide in 2022. Curative surgery, transplantation, ablation, embolotherapy, and systemic therapy have improved outcomes, but many patients remain limited by cirrhosis, liver reserve, vascular…
BackgroundStereotactic ablative radiotherapy (SABR) with dose escalation is increasingly used for pancreatic cancer; however, the dosimetric impact of metallic biliary stents remains poorly characterized. Self-expanding metal stents (SEMS), commonly placed for obstructive jaundice, contain high-density nitinol that produces computed tomography (CT) artifacts, including beam har…
Histotripsy is a novel ultrasound-guided ablation technique that has been approved by the US Food and Drug Administration as a medical device for the noninvasive destruction of liver tumors. The noninvasive, nonthermal, nonionizing mechanical mechanism by which it destroys tumor tissues makes it an appealing local therapy option in the treatment of patients with early-stage hep…
ObjectiveStereotactic body radiotherapy (SBRT) for metastatic spinal disease provides effective local control (LC). However, there are limited data evaluating how the pretreatment volume or number of affected vertebral levels impacts treatment effect. Therefore, this study compared the efficacy of spine SBRT treatment on LC, distant progression (DP), and overall survival (OS) b…
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