Cyclotron F-18 synthesis, Ga-68 generator chemistry, theranostic radionuclide production logistics. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Gaia Dellepiane, Lars Eggimann, Alexander Gottstein, Samuel Juillerat et al.
The theranostic pair 133La/135La has recently attracted growing interest as a promising candidate for combined diagnostic and therapeutic applications, owing to the favorable nuclear and chemical prop…
Erbium-165 is a pure Auger electron emitter with high potential for targeted radionuclide therapy of micrometastases. Following our previous study of the proton-induced pathway, this work investigates…
BackgroundSterol O-acyl transferase 1 (SOAT1) esterifies free cholesterol for storage in the adrenal glands and macrophages. The SOAT1 inhibitor, nevanimibe, has previously been investigated as a ther…
Tosato M, Kleynhans J, van de Voorde M, Favaretto C et al.
β-minus particle (β-)-emitting radionuclides have long been central to targeted radiopharmaceutical therapy. Interest in expanding their repertoire beyond conventional options has grown over time, as …
Radiopharmaceutical therapy and theranostics have rapidly evolved as transformative strategies in nuclear medicine, enabling targeted delivery of therapeutic radiation to malignant tissues while spari…
Hayk Petrosyan, Marine Mnatsakanyan, Isabella Karapetyan, A. Manukyan et al.
Background: 18F-prostate-specific membrane antigen (18F-PSMA-1007) is a recognized positron emission tomography (PET) radiotracer commonly used for prostate tumor imaging due to its excellent tumor-to…
Gaia Dellepiane, Pierluigi Casolaro, Isidre Mateu, Paola Scampoli et al.
Abstract The clinical implementation of copper-based theranostics requires reliable production strategies compatible with routine hospital-based operation. In this work, the feasibility of producing 6…
Andrei Necsoiu, Diana Cocioabă, Radu Leonte, Liviu Craciun et al.
Abstract Background Carbon-11 is an essential radioisotope used in positron emission tomography (PET) for various applications in neurology, oncology and cardiology. Although a method for cyclotron pr…
Abstract Cyclotron-based production of gallium-68 ( 68 Ga) using enriched zinc-68 ( 68 Zn) targets is increasingly adopted as an alternative to generator-based systems. In this approach, electroplatin…
Yokell DL, Dhaynaut M, Neelamegam R, Rice PA et al.
BackgroundIn vivo human studies of the nociceptin/orphanin FQ peptide (NOP) receptor have been limited by the availability and reliable production of suitable PET radioligands. [¹¹C]NOP-1A is a high-a…
Shepherd E, Carrascal Miniño A, Mishra A, Pellico J et al.
Metal-phenolic network (MPN) nanoparticles are growing in popularity as drug delivery vehicles due to their versatile binding interactions, with increased attention to their applications for positron …
The growing societal demand for novel radionuclides across medicine, industry, and science has intensified the need for sustainable and accessible radionuclide production pathways. In addition to dedi…
Yoshida G, Matsumura H, Toyoda A, Nakamura H et al.
BackgroundDuring decommissioning of positron emission tomography (PET) cyclotron facilities, metallic components-including the iron yoke-are typically classified as radioactive waste, incurring substa…
Grespan F, Baltador C, Bellan L, Comunian M et al.
An α-drift tube linac (DTL) is a high-performance linac conceived for radioisotope production. The use of alpha particle beams may make yielding radionuclides hard to obtain with traditional nuclear r…
Speltri G, Favaretto C, Porto F, Napolitano R et al.
The growing demand for medical radiometals calls for more sustainable production strategies that minimize waste and improve resource efficiency. Herein, we present a circular radiometal chemistry appr…
The global rise of theranostic nuclear medicine continues to increase the environmental and economic pressure associated with radiopharmaceutical production. Large-scale manufacturing, reliant on cycl…
Högnäsbacka AA, Cortés González MA, Wiranegara AD, Schou M.
BackgroundIsotopic exchange with fluorine-18 offers a conceptually simple approach to positron emission tomography (PET) tracer development, as the target compound itself serves as the labeling precur…
Saruta M, Shiroki R, Takeuchi A, Yoshizawa A et al.
Abstract Objectives This study evaluated the feasibility and safety of 68 Ga-PSMA-11 PET/CT using an in-house cyclotron-produced 68 Ga in patients with prostate cancer. Methods We prospectively includ…
Glucagon-like peptide-1 receptor (GLP-1R) is a clinically validated therapeutic target for the treatment of obesity and type 2 diabetes. GLP-1Rs expressed in the central nervous system (CNS) regulate …
McCarthy T, Johnston R, Brand MI, Pascali G et al.
Introducing a radioactive nuclide into the appropriate targeting vector allows to diagnose the biochemical correlates of many diseases, or to selectively ablate tumor cells; such capability is steadil…
The clinical efficacy of [10B]borono-l-phenylalanine ([10B]BPA)-mediated Boron Neutron Capture Therapy (BNCT) relies heavily on accurate patient stratification using the companion diagnostic tracer 4-…
Hashimoto H, Ohkubo T, Tsukagoe K, Fujishiro T et al.
We clinically investigated (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl]oxazolidin-2-[¹¹C]-one ([¹¹C]SL25.1188) as a positron emission tomography tracer for imaging monoamine …
Monoamine oxidase B (MAO-B) is highly expressed in reactive astrocytes and is implicated in multiple neurodegenerative and neuropsychiatric conditions, making it an important PET imaging target. Build…
1-[¹⁸F]Fluoroethyl-indole propionic acid (1-[¹⁸F]-IPA), a fluorinated analogue of indole-3-propionic acid (IPA), shows considerable promise as a PET tracer for imaging BxPC-3 pancreatic cancer xenogra…
The increasing demand for medical radionuclides highlights the need for more diversified and resilient production strategies. This work presents a systematic methodology for prioritising medical radio…
Muzzioli R, Pisaneschi F, Gammon ST, Sutton MN et al.
Talazoparib (TZ) is a potent poly(ADP-ribose) polymerase 1/2 (PARP1/2) inhibitor that uniquely traps PARP complexes at sites of single-strand DNA damage thereby offering opportunities for targeted rad…
BackgroundTerbium-161 (¹⁶¹ Tb) is an emerging therapeutic radionuclide combining β⁻ emission with a high yield of Auger electrons and conversion electrons, enabling enhanced localized dose deposition.…
ObjectiveThis Phase I/IIa study evaluated the safety, pharmacokinetics, internal radiation dosimetry, and image quality of cyclotron-produced ⁶⁸Ga-PSMA-11 synthesized using an automated module in a Ja…
Aluicio-Sarduy E, Wehner LE, Jeffery JJ, Levitt NP et al.
Targeted α-therapy (TAT) is a promising therapeutic strategy for advanced cancers, but redistribution of short-lived daughter radionuclides remains a key challenge. This is particularly true for ²²⁵Ac…
BackgroundEpidermal Growth Factor Receptor (EGFR) overexpression in Head and Neck Squamous Cell Carcinoma (HNSCC) is well documented and strongly correlated with aggressive phenotypes. As such EGFR is…
Background4-Borono-2-[18F]fluorophenylalanine ([18F]FBPA) is an important imaging agent for identifying suitable candidates for boron neutron capture therapy (BNCT). This study aimed to develop three …
BackgroundFibroblast Activation Protein (FAP) is a critical target for imaging cancer-associated fibroblasts and active hepatic stellate cells in liver fibrosis. While FAPI-2286 has been widely explor…
Abstract Techetium-99m, the decay product of Molybdenum-99, is the most utilized radioisotope for diagnostic purposes. The demand for 99m Tc is more than 80% of all nuclear medicine radioisotopes. In …
Using various theoretical models within TALYS-2.0, we computed excitation functions, thick-target yields at EOB and 12-h post-EOB impurity analysis. Models were selected for each reaction route using …
BackgroundGallium-68 (68Ga) is a PET isotope that is finding more use in the clinical setting as a PET diagnostic tool, for example 68Ga PSMA is widely used in the diagnosis of prostate cancer, and 68…
BackgroundInsulinoma is a rare pancreatic neuroendocrine tumour characterised by inappropriate insulin secretion and recurrent hypoglycaemia. Owing to their small size and intrapancreatic localisation…
Gallium-67 can be produced on proton cyclotrons via the ⁶⁷Zn(p,n)⁶⁷Ga and ⁶⁸Zn(p,2n)⁶⁷Ga routes. In this study, TALYS, SRIM, and FLUKA calculations were combined to compare ⁶⁷Ga production and post-ir…
The production of radionuclides for nuclear medicine is crucial for advancements in both diagnosis and therapy. ¹⁵⁵Tb stands out as a promising candidate for SPECT imaging and as counterpart of the th…
BackgroundThe production of Scandium-47, a promising radionuclide for targeted radionuclide therapy, was investigated via proton-induced reactions on enriched Ca-48 using the EMPIRE nuclear reaction c…
Schultz SJ, Adelman SL, Dutech GH, Fassbender ME et al.
Numerous promising cancer treatments currently in clinical trials rely on the production and purification of actinium-225 (²²⁵Ac), an actinide with alpha emissions that can kill cancer cells via targe…
Incorporation of carbon-11 radiotracers for positron emission tomography (PET) imaging requires close coordination between cyclotron operation, radiochemistry production, quality control, and clinical…
[¹⁸F]Fluoroarenes feature prominently as radiotracers for biomedical imaging with positron emission tomography (PET). We report the syntheses of a wide range of triphenylselenonium triflates and demon…
The uptake and elution behavior of Ra and Ac was studied on TK101 resin using acetic acid and acetate buffer (acetic acid/lithium acetate) solutions. There is high extraction of Ra (>10³) over a wide …
Closing the loop in nanotheranostics, we integrate radionuclide production with functional nanomedicine through mesoporous alumina based radiochemical separation of no-carrier-added (NCA) ¹²⁴I and its…
Kushwaha K, Pathak K, Sabharwal TP, Kamble S et al.
BackgroundMolecular imaging enables the non-invasive visualization of physiological processes at the cellular and molecular levels and is central to diagnostic nuclear medicine. Among clinically impor…
With the emission of both Auger and conversion electrons (AE and CE) together with some x-rays and a few low intensity gamma-rays, palladium-103 (¹⁰³Pd, T1/2 17 d) and its daughter rhodium-103m (103mR…
In-house production of FDG is increasingly necessary to ensure a stable supply of PET tracers. However, the establishment of new production facilities is often accompanied by unforeseen technical chal…
Emerging metallic radionuclides are expanding theranostic capabilities in nuclear medicine by improving diagnostic sensitivity, enabling dosimetry, and matched theranostic approaches. ¹⁴⁹Tb, ⁴⁴Sc, ⁵²M…
Ragot M, Reynaud-Orhon P, Revy A, Batisse-Lignier M et al.
Background[⁶⁸Ga]Ga-NODAGA[40Lys]-Exendin-4 (⁶⁸Ga-Ex-4) is a new PET radiopharmaceutical targeting GLP-1-R that showed great specificity and sensitivity in the topographic diagnosis of benign insulinom…
Coussirou A, Six M, Edet-Sanson A, Salles A et al.
BackgroundProstate cancer (PCa) has been identified as the most prevalent form of cancer among males and the third leading cause of death from cancer in the European male population. Early-stage PCa c…
BackgroundThe radiosynthesis of gallium-68 radiopharmaceuticals is influenced by the bifunctional chelating agents (BFCAs) used for chelation. The reaction parameters such as reagent concentration, pH…
Brühlmann SA, Brandt F, Walther M, Zhutova N et al.
Gallium-67 remains a relevant radionuclide for single-photon emission computed tomography (SPECT) and radiopharmaceutical development as a longer-lived ⁶⁸Ga surrogate. In this work, the use of gold an…
BackgroundIn-house ^18F-FDG production is increasingly adopted by hospitals, yet few studies have quantified how environmental and operational factors influence radiochemical yield during real-world c…
BackgroundThe handling of non-sealed radiopharmaceuticals poses significant risks of occupational exposure and radioactive contamination. With rapid growth in demand, an increasing number of workers a…
Objective: Current good manufacturing practice (cGMP) guidance for positron emission tomography (PET) drugs has been established in Europe and the United States. In Japan, the Pharmaceuticals and Medi…
The establishment of a compliant radiopharmacy facility within a university setting is crucial for supporting fundamental and preclinical studies, as well as for the production of high-quality radioph…
Nelson BJB, Andersson JD, Wuest F, Spreckelmeyer S.
BackgroundThe radiometal gallium-68 (⁶⁸Ga) is increasingly used in diagnostic positron emission tomography (PET), with ⁶⁸Ga-labeled radiopharmaceuticals developed as potential higher-resolution imagin…
Ahenkorah S, Cassells I, Deroose CM, Cardinaels T et al.
In contrast to external high energy photon or proton therapy, targeted radionuclide therapy (TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and all its metastase…
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