Alpha-therapy in bone-metastatic mCRPC — ALSYMPCA legacy, sequencing with Lu-177 PSMA, and updated guidance. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Rheumatoid arthritis (RA) is a persistent autoimmune disorder where traditional serological indicators, including rheumatoid factor and anti-citrullinated protein antibodies, are inadequate for early and precise diagnosis, and existing anti-cytokine treatments have effectiveness and safety constraints. Recent data indicates that non-coding microRNAs (miRNAs) play a crucial role…
Background The incidence of gestational diabetes mellitus (GDM) continues to rise in China, and the risk of neonatal pneumonia is significantly increased, but the primary medical institutions lack simple and effective early risk assessment methods. Objective To construct a prediction model for neonatal pneumonia suitable for primary medical institutions, based on readily availa…
Ploylarp Lertvipapath, Weerapat Owatanapanich, Waratchaya Uawattanasakul, Smith Kungwankiattichai
Deferiprone (DFP) is an effective oral iron chelator widely used in adult patients with thalassemia, particularly for cardiac iron removal. However, DFP is associated with rare but potentially life-threatening hematological adverse effects, notably neutropenia and agranulocytosis. Real-world data on the incidence, timing, risk factors, and outcomes of DFP-induced neutropenia in…
Abstract A key challenge in earthquake hydrogeology is separating hydrogeochemical changes induced by seismic activity from those driven by natural recharge dynamics. This study provides a comprehensive long-term multiparameter analysis of hydrogeochemical parameters and dissolved radon concentrations in groundwater, monitored at four springs in the Matese area (central-souther…
Background: Chronic Kidney Disease (CKD) represents a major global health concern, leading to serious outcomes such as progression to End-Stage Renal Disease (ESRD), complications arising from reduced kidney function, and a heightened risk of Cardiovascular Disease (CVD) Serum albumin is a marker of malnutrition as well as inflammation and has been demonstrated as a strong pred…
Glutamine, the most abundant amino acid in human serum, serves not only as a key nutrient for maintaining normal cellular biological functions but also as an essential metabolic substrate for the proliferation and survival of tumor cells. Tumor cells exhibit a pronounced characteristic of “glutamine addiction” through metabolic reprogramming. This trait endows tumor cells with …
Sandra Milena Zuleta Alarcón, Anderson Bermon Angarita, Alejandra Mendoza-Monsalve
Background Road traffic injuries are a major public health and economic burden, particularly in low- and middle-income countries, where increasing motorization and limited trauma system capacity contribute to healthcare expenditures. Evidence on factors associated with hospital costs in Latin America remains limited. Objective To evaluate sociodemographic, accident-related, and…
Isabella Ho, Cindy Leung, Nidhi Bhandari, Hsi‐Ming Lee et al.
Background Matrix metalloproteinases (MMPs) play critical roles in periodontal tissue destruction. The present study evaluated the efficacy of a novel chemically modified curcumin 2.24 (CMC 2.24) in reducing MMP levels, activity, and its activation, in a periodontal relevant cell culture model involving human mononuclear THP-1 cells. In addition, the p38 mitogen-activated prote…
Background: People with bronchiectasis suffer from chronic cough and sputum production. Repeated acute exacerbation may result in increased incidence of hospitalization and decline in health related quality of life. Physiotherapy involvement in the management of bronchiectasis is supported by international guidelines which states that individuals with a chronic productive cough…
Abstract Parent–adolescent sexual communication is an established protective factor for adolescent sexual health. However, the specific family-level antecedents predicting these conversations remain poorly understood. Using longitudinal Adolescent Brain Cognitive Development (ABCD) data ( N = 4,593), we examined how family Cohesion, Conflict, Expressiveness, and Intellectual-Cu…
Somayeh Shamlou, Hossein Rostami, Ali Hassanzadeh, Simin Rajaeian et al.
Background: Degenerative diseases place an immense burden on global healthcare. Stem cell-based regenerative medicine offers transformative, potentially curative therapies to restore damaged tissues and recover normal physiological function. Aim: This review aims to comprehensively evaluate the therapeutic applications, biological mechanisms, and clinical prospects of stem cell…
Building on our previous Multiconfiguration-Dirac-Hartree-Fock (MCDHF) computational strategies taylored for the hyperfine structure (HFS) of low-lying levels in one-valence electron Sr II and Ba II ions, and in two-valence electrons Ba I atom [Nezosi et al, Atoms 14, 17 (2026). DOI: 10.3390/atoms14030017], we successfully extend these methodologies along the alkaline-earth ele…
In this article, the hadith/narration relationship between two important hadith and fiqh scholars of the second century of Anno Hegirae (AH/Hijri), Ja‘far al-Sādiq (d. 148/765) and his student Imam Malik (d. 179/795), is discussed in the context of Muwatta'. In the Muwatta, there are 14 hadiths/narrations whose chain of transmission includes Ja‘far al-Sādiq, and which he narrat…
Hongfei Sun, Xinran Xie, Mingru Ma, Hongbin Li et al.
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a central role in the pathogenesis of LN. Aberrant activation of the NLRP3 inflammasome directly promotes glomerular injury, proteinuria, and tubulointerstitial fibrosis throu…
Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are integrated within individual enzyme…
J.C. van Ditshuizen, L. Van Den Berg, M.H.J. Verhofstad, PHC Leliefeld et al.
PURPOSE: Major trauma can have a long-term impact, leading to diminished health-related quality of life (HRQoL) for patients and their significant others (SOs). Patient reported outcome measures (PROMs) make this impact visible, providing expectation- and self-management. European studies assessing Significant Other Reported Outcome Measures (SOROMs) in cohorts of severely inju…
Junyu Lu, Weiming Wang, Deyi Ji, Lanyun Zhu et al.
Abstract Toxic content detection and safeguarding have become important topics in natural language processing and affective computing, as they involve the analysis of offensive expressions and harmful attitudes in language. With the widespread adoption of social media, diverse forms of user-generated toxic content have imposed substantial harm on individuals and society. In par…
Emerging contaminants (ECs) are increasingly reported in surface water, groundwater, wastewater, sediments, and drinking water sources. However, their occurrence, environmental fate, exposure risks, monitoring challenges, and treatment needs remain inadequately assessed in many low- and middle-income countries (LMICs). This review critically examines and provides an update on r…
Qi Wang, Peng Cai, Zhu Zhenwei, Jianlei Chen et al.
Background Choledochal cysts (CCC) are common congenital biliary malformations in children. Early diagnosis and standardized surgery are critical for prognosis. Preoperative imaging is essential for classification and surgical planning, but the value of different modalities remains unclear. Purpose This study aimed to investigate the value of preoperative imaging in guiding sur…
Jingyi Zhang, Yuanyuan Li, Qiong Yang, Peilin Su et al.
Soil organic carbon (SOC) and soil total nitrogen (STN) play crucial roles in the sustainability of soil production and ecological service function. Spatially explicit estimations of SOC and STN and the identification of factors influencing the spatial variability of them are prerequisites for formulating and implementing site-specific management measures to improve soil qualit…
Nicholas J Bail, Megan Higgie, Daniel J. Ferguson, Conrad J. Hoskin
Abstract Globally, many species have small, fragmented populations and hence genetic factors become a primary threat to their persistence. The Critically Endangered Nangur Spiny Skink ( Nangura spinosa ) inhabits vine thicket in Nangur and Oakview National Parks in south-east Queensland, Australia. The two populations are naturally isolated and are now very small, with census e…
Ayşe Gizem Yıldız, Didem Demir, Ahmet Kurt, Hatice Ayhan et al.
Objective: A significant portion of the complications that may arise during pregnancy and childbirth can be prevented through education and appropriate care approaches. This study aims to evaluate the association of prenatal education class attendance with pregnancy-related anxiety, fear of childbirth, and obstetric outcomes.Methods:This prospective observational comparative st…
Introduction Airway epithelial injury is a central feature of asthma and contributes to persistent airway inflammation, mucus overproduction, and airway remodeling. House dust mite (HDM) is a major aeroallergen associated with allergic asthma, yet the intracellular stress responses underlying HDM-induced epithelial damage remain incompletely understood. Here, we investigated ch…
Background Acute appendicitis is one of the most common surgical emergencies in children, and timely empirical antimicrobial therapy is particularly important in complicated cases. However, antibiotic selection is increasingly challenged by regional variability in pathogen distribution and antimicrobial resistance. This study aimed to characterize the microbiological spectrum a…
Emanuele Durante‐Mangoni, Augusto Delle Femine, Raffaella Gallo, Ciro di Gennaro et al.
Abstract Arboviral diseases are emerging and affect approximately 60 million individuals yearly. Climate change, vector migration patterns, urbanisation and global travel are boosting their spread beyond traditionally endemic regions, including Europe. This narrative review provides a practical and clinically oriented overview of the main arthropod-borne viral infections. We su…
The present study focused on the development and application of LC-MS/MS methodologies for hormonal and metabolite profiling. The project pursued four objectives: optimization of LC-MS/MS protocols for the quantification of extended exogenous and endogenous steroid panels in dried blood spots (DBS); analysis of DBS samples for a broad steroid panel using an internal calibration…
Abstract Neuroinflammation is no longer a secondary feature of amyotrophic lateral sclerosis (ALS), but rather a disease-modifying process that actively shapes the motor neuron vulnerability from the earliest stages of pathology. Central and peripheral immune cells, including microglia, astrocytes, and infiltrating T lymphocytes, adopt context-dependent states that can be neuro…
Abstrak: Penelitian ini bertujuan menganalisis upaya preventif Satuan Polisi Pamong Praja (Satpol PP) dalam menekan pelanggaran Peraturan Daerah yang berpotensi berkembang menjadi tindak pidana, dengan menelaah bentuk tindakan pencegahan, strategi pelaksanaan, pola koordinasi lintas lembaga dan kendala implementasi. Penelitian menggunakan metode hukum normatif-empiris dengan de…
Shohei Yamashita, Hirofumi Shoda, Yusuke Yamamoto, Toshihiro Matsui et al.
Abstract Background: Janus kinase inhibitors (JAKi) are effective for rheumatoid arthritis (RA) and can be used as monotherapy; however, the clinical benefit of concomitant methotrexate (MTX) and the optimal MTX dose in JAKi-treated patients remain unclear in real-world settings. In this study, we aimed to clarify the roles of MTX by comparing the patient profiles between JAKi …
Abstract Neuropeptides are found in nearly every brain neuron, and can modulate behaviors by regulating neuronal excitability, synaptic transmission, and plasticity. In contrast to the canonical view of neuropeptide release from nerve terminals, we previously reported the somatodendritic release of cholecystokinin (CCK) from ventral tegmental area (VTA) dopamine (DA) neurons. R…
Almuth Neuberger, Rahul Ranjan, Hao Ding, Fredrik Mattsson et al.
Abstract. Air pollution and fog are closely connected, influencing both visibility and human health. As relative humidity rises, aerosol particles absorb water and grow hygroscopically, potentially activating into fog droplets when supersaturation is reached. Distinguishing between hydrated (non-activated) aerosols and activated particles is critical, as their differing thermod…
Abstract We extend an inequality of Merryfield, valid in the continuous setting, to discrete multiparameter martingales. As a consequence, we obtain the comparison of the maximal function with the square function: for regular multiparameter filtrations and . This estimate is new in the case of more than two parameters, and provides an alternative proof of Brossard's famous two‐…
Tsubasa Kondo, Mika Sakamoto, Mayuko Tokumaru, Yasuhiro Tanizawa et al.
High-quality reference genomes provide an essential foundation for elucidating the molecular basis of organismal ecophysiology. Here, we sequenced and assembled chromosome-scale genomes of two Heterosigma akashiwo strains isolated from coastal waters of Japan and France. The assembly sizes were 1.18 Gb and 1.43 Gb for the Japanese and French strains, respectively. The scaffold …
Nithya P Kasibhatla, Christine W. Peng, Helmet T. Karim, Anusha Rangarajan et al.
Background Childhood adversity is linked to psychopathology risk and dysregulated stress reactivity; however, unified underlying neural mechanisms are unclear. A central visceral network, including the bed nucleus of the stria terminalis (BNST), amygdala and subgenual anterior cingulate cortex (sgACC), is implicated in affective processes and proximally controls stress reactivi…
Objective: To describe the perioperative and longer-term outcomes of a single-center cohort undergoing transanal endorectal pull-through (TEPT) for Hirschsprung disease (HSCR), and to identify independent predictors of postoperative Hirschsprung-associated enterocolitis (HAEC). Method: A retrospective review of 71 patients undergoing TEPT at a single institution was performed. …
Gunasingh Masilamoni, Rosa M. Villalba, Jean‐François Paré, Yoland Smith
The ventral motor and the centromedian (CM) nuclei receive prominent GABAergic inputs from the basal ganglia, massive glutamatergic projections from motor cortices and significant GABAergic afferents from the reticular thalamic nucleus. There is strong evidence that disrupted processing of information through these connections may contribute to the pathophysiology of the basal …
Muhaimen Habib, Khalil Ismail Abid Mohammed, Mohammed Alosami
Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease, which primarily affects the joints and is characterized by inflammation of synovial joints. Objectives: The study aimed to detect the levels of ESR, CRP, and ACCP with VIM and LTB4, and to investigate the prognostic value of these biomarkers included in the study in a comparison with AC…
Howyn Tang, Gary Sun, Chao Lu, Hossein Pouri et al.
Early and accurate identification of disease-associated biomarkers is essential for timely diagnosis and the advancement of personalized healthcare. Although blood and cerebrospinal fluid remain the clinical gold standards, increasing attention is being directed toward non-invasive biofluids, such as urine, saliva, tears, and sweat. as accessible and patient-friendly alternativ…
Julianna Chyl, Łukasz Kowalewski, Oliwia Gutowska, Weronika Nowak et al.
Background. The diabesity epidemic (obesity and type 2 diabetes) requires a shift from a glucocentric to a holistic approach, making weight reduction a clinical goal equal to glycemic control. Incretin-based therapies (semaglutide, tirzepatide) represent a breakthrough due to their pleiotropic effects. Aim. This study analyzes their efficacy, safety, molecular mechanisms, and c…
Stephen O. Awodele, Krishna K. Gali, Bunyamin Tar’an, Sabine Banniza et al.
Fav-Ps2.1 is the first major QTL reported for Fusarium avenaceum resistance in pea and co-localizes with Mendel’s A gene and putative resistance genes. A novel moderate-effect QTL Fav-Ps5.1 and one epistatic locus, independent of the A gene, were also reported. Flavonoid compounds associated with resistance to this pathogen were identified. Fusarium avenaceum , a necrotrophic s…
João Sartori, Ana Carolina Ramos Guimarães, Lucas de Almeida Machado
Accurate computational prediction of enzyme function, standardized by Enzyme Commission (EC) numbers, is essential for large-scale genome annotation and generative enzyme design. However, it remains unclear whether state-of-the-art predictors learn the intrinsic structural determinants of catalytic activity or merely rely on global sequence similarity to annotated homologues. T…
Yingying Guo, Jianfei Zheng, Lei Liu, Shulin Li et al.
The endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is a dynamic membrane system at the ER-Golgi interface, traditionally viewed as a transient station for COPII- and COPI-dependent trafficking. Emerging evidence redefines the ERGIC as a stress-responsive regulatory hub that integrates membrane trafficking with cellular adaptation. In addition to coordinating bidir…
Saisai Wang, Yuchen Shang, Rong Fu, Musen Li et al.
Paracrystallization provides a route to achieving synergistic properties beyond conventional property trade-offs, but applying it to layered materials is challenging due to strong bonding anisotropy. Here, we report the synthesis of paracrystalline graphite, a paracrystalline state realized in a layered material, through a high-pressure-driven “local graphitization” of C60 crys…
David L. Auer, Fadil Elamin, Konstantin J. Scholz, Duc Pham et al.
OBJECTIVE: This study investigated the impact of the Sudanese smokeless tobacco Toombak on cultivable oral bacteria, its potential antibacterial properties, and its own microbial composition. MATERIALS AND METHODS: Oral swabs from 20 adult male participants, including ten long-term Toombak users and ten non-users, were analyzed through microbial inoculation and identification t…
What makes long-term policy issues rise to the legislative agenda in the state-level policymaking process? More specifically, why have sea level rise adaptation policies gained traction in some states but not others? The following paper presents a case study of the State of Hawai’i, which is critically vulnerable to sea level rise impacts. The study operationalizes the concept …
Rab Nawaz, Mohanad A.Alfellag, S.N. Kazi, Bee Teng Chew et al.
Nanofluids have progressively gained popularity as thermodynamic fluids due to their intriguing qualities in terms of thermal conductivity. Though the nanofluids have gained greater attention in heat-transfer applications, their suspension stability is still not resolved, especially for the metal oxide nanofluids. Therefore, this study aims to functionalize titanium dioxide (Ti…
Alaa Abd‐Elsayed, Marco P. Troka, Jesús López Ortega, Anthony I. Riad et al.
Surgical site infections (SSIs) remain a critical postoperative complication that causes significant morbidity, mortality, and healthcare costs. To mitigate these risks, intrawound vancomycin powder has been increasingly adopted as a prophylactic option, particularly for high-risk procedures such as spine, orthopedic trauma, and cardiothoracic surgeries. However, the decision u…
C. Wainwright, Neil Harris, Rob O’Leary, Tom Riley et al.
Civic disengagement among young adults is a significant societal challenge, exacerbated in those experiencing mental ill-health where stigma and social isolation can create a debilitating cycle of withdrawal. This exploratory study investigated how advocacy training for young people with mental ill-health cultivates self-determination through efficacy and increases civic partic…
Cheng Cheng, Yuzhen Li, Zhenzhi Wang, Hui Chen et al.
Budding yeast Saccharomyces cerevisiae and various non-conventional species are widely applied in the production of diverse industrial products, including pharmaceuticals, biofuels, biochemicals, and biomaterials, due to their rich natural and engineered biodiversity. This review summarizes recent advances in harnessing yeast biodiversity for industrial applications, including …
Compliant Pre-Stress (CPS) device uses a compressive osseointegration technique for endoprosthetic fixation and provides an alternative to stemed implants. Despite having benefits, such as bone stock retention, periprosthetic fractures continue to remain a concern. Therefore, this systematic review presents the prevalence, risk factors, and outcomes of the CPS device and peripr…
Tell us who you are and we’ll send the full product brochure to your institutional email after a quick review. We respond within one working day (Mon–Fri, 9:30–18:30 IST).
Request received
A Saxsons sales engineer will review your request and send the brochure to your institutional email within one working day. You may receive a verification call before processing.
