Theranostics · Literature Radar
FAP-targeted radioligand therapy — pancreatic, sarcoma, breast, head-and-neck investigational evidence. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Okuyan M, Elboga U, Sahin E.
ObjectivesTo compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) PET/CT and ⁶⁸Ga-FAPI PET/CT in patients with gastric cancer, with particular emphasis on metastatic detection and st…
Bentestuen M, Makieva I, Andersen TB, Ladekarl M et al.
Previous studies have demonstrated promising results for radiolabeled fibroblast activation protein inhibitor (FAPI) PET/CT in gastric cancer (GC) when compared with [¹⁸F]FDG PET/CT. In this prospecti…
Feng LJ, Wang H, Zhang W.
We present [18F]AlF-NOTA-FAPI-04 PET/CT findings of an incidentally detected benign phyllodes tumor in a 68-year-old woman with prior colon cancer. Routine contrast-enhanced CT revealed a right breast…
Huang X, Zhang Y.
Low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is a rare entity. We report a 27-year-old man with a 1-year history of bloody postnasal drip. MRI revealed a protuberance on the roof and pos…
Rabani F, Samadi MH, Sadeghpour S, Anaraki SZ et al.
This report evaluates 99mTc-FAPI-46 SPECT/CT in 2 young men with advanced metastatic Ewing sarcoma, demonstrating high tumor-to-background contrast and broad lesion detectability for skeletal and soft…
Narita Y, Komori S, Adaniya S, Momose T et al.
A 79-year-old man underwent proton beam therapy (PBT) for hepatocellular carcinoma. During follow-up, MRI demonstrated stable T2-weighted hyperintensity in the irradiated region without interval enlar…
Zhang W, Dong Y, Xu L, Liao P et al.
PurposeThis study was designed to investigate the detection rate and tumor uptake of 18F-AlF-NOTA-De-FAPI PET/CT in newly diagnosed high-risk prostate cancer (PCa), compared with 68Ga-PSMA-11 and 18F-…
He M, Yang H, Shi Y, Zhang R et al.
Predicting pathological complete response (pCR) after neoadjuvant short-course radiotherapy combined with immunotherapy and chemotherapy remains challenging in microsatellite-stable (MSS) locally adva…
Amalo RB, Cahyani A, Budiawan H, Darmawan B et al.
PurposeIntracranial space-occupying lesions (SOL), including primary brain tumors, metastases, and inflammatory lesions, require accurate characterization for diagnosis and management. Although ¹⁸F-FD…
Li H, Zhang Y, Ren X, Liu C et al.
BackgroundMost preclinical studies of fibroblast activation protein (FAP)-targeted radionuclide therapy (FAP-RNT) use immunodeficient xenografts, limiting evaluation within an intact immune microenvir…
VAN DEN Bos M, VAN Duijvenvoorde M, Poot AJ, Bol GM et al.
BackgroundThe aim of the study is to evaluate the diagnostic performance of fibroblast activation protein inhibition (FAPI)-PET/CT imaging for cancer patients in a real-world setting.MethodsAll patien…
Zhao M, Lin X, Zhou N, Yu B et al.
PurposeThe evaluation of lymph node metastasis in colorectal cancer (CRC) remains a critical challenge, as it significantly impacts prognosis and treatment decisions. PET/MRI with various tracers may …
Mu X, He G, Huang X, Li J et al.
ObjectivesTo determine whether preoperative [¹⁸F]FAPI-42 PET/CT is associated with postoperative pathological phenotypes and tumor budding grade in colorectal cancer.Materials and methodsThis retrospe…
Fortuna I, Santos J, Soeiro P, Machado R et al.
Myocardial fibrosis is a major pathological component of cardiac remodelling and contributes to ventricular stiffness, impaired myocardial function, heart failure progression, and arrhythmic vulnerabi…
Duan SD, Li L, Chen BX, Yang MF.
Atrial remodeling in atrial fibrillation (AF) involves multiple biological processes, including metabolic alterations, inflammation-related metabolic activity, and fibroblast activation, which can be …
Jia F, You H, Li X, Cheng L et al.
Fibroblast activation protein (FAP) is a promising pan-tumor target for theranostics, but current FAP-targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses…
Tang S, Jin Z, Wu T, Liu Y et al.
Fibroblast activation protein (FAP)-targeted radioligand therapy is often limited by insufficient tumor uptake and retention. We designed and synthesized two novel aryl fluorosulfate-based covalent FA…
Wu W, Pan Y, Ren C, Xu W et al.
Improving the tumor uptake and retention without compromising background clearance remains challenging for fibroblast activation protein inhibitor (FAPI) radiotracers. Current approaches usually intro…
Banerjee SR, Boinapally S, Minn I, Das D et al.
Fibroblast activation protein (FAP) is a validated PET imaging target for the tumor microenvironment. Currently, most 18F-labeled FAP PET agents use Al-F chemistry, with Al18F-FAPI-74 leading clinical…
Sridhar A, Behiri N, Klubo-Gwiezdzinska J.
The incidental thyroid uptake of radiolabeled ligands used in positron emission tomography/computed tomography (PET/CT) targeting cell-surface proteins is observed in up to 6% of all scans. While diff…
Pourbehi MR, Juweid ME, Jafari E, Jokar N et al.
BackgroundPost-myocardial infarction (MI) remodeling is driven by dynamic interactions between inflammatory and fibrotic processes. Conventional imaging techniques primarily detect established scar bu…
Li R, Ding L, Tan B, Jin S et al.
Bifunctional chelators are essential for the development of novel radiopharmaceuticals. For the ⁶⁸Ga-based radiopharmaceuticals, previously reported chelator 2-[11,27-bis(carboxymethyl)-34,36-dihydrox…
Teuter M, Balakrishnan A, Hu Y, Lolatte K et al.
As the global burden of liver disease is increasing, the interplay between inflammation and fibrosis is emerging as a promising target for antifibrotic hepatic therapies. Such advanced interventions w…
Enke JS, Barton AK, Kimura K, Calais J et al.
Fibroblast activation protein (FAP) has gained clinical interest as a target for imaging and therapy in a spectrum of oncologic diseases in recent years. Yet, FAP expression by activated fibroblasts i…
Liu Y, Ma X, Yang J, Yang J et al.
A 49-year-old woman with cT3N1M0 stage IIIA HER2-positive invasive breast cancer is described in this retrospective case report. After six cycles of TCHP neoadjuvant chemotherapy, breast MRI confirmed…
Hettler M, Menge F, Ludwig J, Nörenberg D et al.
BackgroundFibroblast activation protein inhibitor (FAPI)-targeted positron emission tomography (PET) has emerged as a promising imaging approach in soft tissue sarcomas (STS), whereas magnetic resonan…
Lenaerts M, Duijx LEHW, Mottaghy FM, Bauwens M et al.
Introduction. [¹⁸F]FDG can be considered as PET tracer to determine whole-body staging in patients with locally advanced (LABC), metastatic, and recurrent breast cancer. Yet, previous studies demonstr…
Wen Y, Xue P, Wang Y, Ta H.
BackgroundDigestive system malignancies frequently recur because occult lesions and microscopic residual disease may persist despite apparently complete resection. The authors evaluated an integrated …
Xu Y, Qiu H, Guo C, Wang Q et al.
Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) has emerged as a promising molecular imaging modality for visualizing fibroblast activation and…
Lin M, Chen Z, Chen S, Zheng J et al.
PurposeThis study aimed to evaluate the association of atherosclerosis [⁶⁸Ga]Ga-FAPI-04 uptake with calcified plaque burden, cardiovascular risk factors (CVRFs), and to compare these findings with [¹⁸…
Elahifard H, Samadi MH, Bari A, Soltani E et al.
A 66-year-old man with inoperable malignant scalp melanoma, refractory to immunotherapy, underwent 99mTc-HYNIC-TOC SPECT/CT for evaluating the possibility of radioligand therapy with 177Lu-DOTATATE, w…
Rabani F, Taheri F, Torghabeh AE, Kamali H et al.
We present a 54-year-old man with hepatocellular carcinoma (HCC) presenting with diffuse bone pain 6 months postradiofrequency ablation. 99mTc-FAPI-46 SPECT/CT was performed to evaluate disease extent…
van den Bos M, Vogel WV, van Duijvenvoorde M, Kok NFM et al.
Colorectal cancer patients with peritoneal metastases have a very poor prognosis. A minority of these patients is eligible for curative cytoreductive surgery (CRS) and hyperthermic intraperitoneal che…
Rabani F, Elahifard H, Tanha AS, Bari A et al.
We report the case of a 58-year-old man with metastatic epithelioid sarcoma demonstrating an uncommon presentation of expanding tumor volume accompanied by a paradoxically lower SUVmax on 18F-FDG PET/…
Wang Y, Hu M, Pi R, Shu H et al.
PurposeFibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts (CAFs) and has emerged as an important target for tumor imaging and therapy. Although numerous FAP-targe…
Li Y, Sun L, Pan X, Lin S et al.
Triple-negative breast cancer (TNBC) features pronounced molecular heterogeneity and poor prognosis, restricting the efficacy of single-targeted strategies. Leveraging the complementary theranostic ta…
Lei Q, Huang L, Zhou L, Xiang K et al.
Primary extraosseous Ewing sarcoma located in the abdominal cavity and retroperitoneum is rare. We report the 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT imaging findings of intra-abdominal Ewing sarcoma. …
Li Y, Sun L, Pan X, Lin S et al.
Chen B, Sun M, Li N, Xu Z et al.
Fibroblast activation protein (FAP), which is highly expressed in cancer-associated fibroblasts, has emerged as an attractive target for tumor imaging and radionuclide therapy. However, FAP-targeted r…
Chen Y, Xiao Y, Zhang Z, Rao M et al.
Sarcomas represent a heterogeneous group of malignant neoplasms arising from mesenchymal tissue and remain challenging to diagnose and treat. Fibroblast activation protein (FAP), highly expressed in t…
Jia J, Zhou C, Yi S, Zheng J et al.
ObjectivesFluorine 18 (¹⁸F)-labeled fibroblast activation protein inhibitor-04 (denoted as FAPI-04) positron emission tomography/computed tomography (PET/CT) has showed excellent diagnostic performanc…
Liu S, Zhang X, Li R, Kong Z et al.
ObjectiveIncorporating a sulfur (VI)-fluoride exchange (SuFEx) chemistry-based linker, FAPI-based covalent targeted radioligand (CTR) showed better tumor binding affinity and longer retention time tha…
Tatoğlu MT, Baydaş T, Uslu H.
A 60-year-old man with signet-ring-component poorly differentiated rectal adenocarcinoma (pMMR, HER2-negative, KRAS/NRAS/BRAF wild-type) received total neoadjuvant therapy, low anterior resection, and…
Yang H, Liu L, Jia G, Gao H et al.
Targeted radioligand therapy (TRT) is an emerging treatment modality that selectively delivers radioisotopes to tumors while sparing healthy tissues. However, optimizing TRT radiopharmaceuticals to co…
Araz M, Soydal Ç, Konca C, Dursun E et al.
PurposeTo evaluate the role of ⁶⁸Ga-FAPI PET/CT in primary staging of breast cancer in comparison with ¹⁸F-FDG PET/CT.MethodsIn this prospective study, 50 breast cancer patients (49F,1M, age:54.56 ± 1…
Mou L, Zhang T, Zhang X, Zhou J et al.
BackgroundThyroglobulin (Tg) is a standard biomarker for monitoring differentiated thyroid carcinoma (DTC) after radioiodine therapy, yet its reliability is compromised by false-positive and false-neg…
An P, Wu L, Wang R.
Liver fibrosis links chronic liver injury to cirrhosis, hepatic decompensation, and hepatocellular carcinoma (HCC), while current non-invasive tests mainly estimate fibrotic burden and incompletely ca…
Jeanjean P, Swaidan A, Tse C, Kwock S et al.
Glioblastoma represents the most lethal form of brain cancer, characterized by a 5-y survival rate of approximately 4%. Fibroblast activation protein (FAP), expressed within both the tumor microenviro…
Wang J, Jia Y, Xiang J, Lin K et al.
ObjectiveSjögren's disease (SjD) is an autoimmune exocrinopathy characterized by chronic glandular inflammation. Fibroblast activation protein (FAP) is a promising imaging biomarker for local inflamma…
Sahu S, Chakraborty A, Lad S, Rakshit S et al.
Fully automated, multiple patient dose preparation of [⁶⁸Ga]Ga-FAPI-4 was standardized using a commercial fixed tubing (non-cassette) based automated module namely Eckert and Ziegler 'Modular-Lab Stan…
McConathy J, Koshkin VS, Menda Y, Rodon J et al.
PurposeFibroblast activation protein (FAP) is an attractive target for radiopharmaceutical therapy. Phase I of the LuMIERE study (ClinicalTrials.gov, NCT04939610) investigated the safety of [177Lu]Lu-…
Xudong Zhang, Ke Duan, YuHan Long, Tong Zhou
Purpose: Radionuclide therapy targeting fibroblast activation protein (FAP) offers an effective treatment for tumors with high FAP expression, such as those imaged with 68 Ga-fibroblast activation pro…
Liang Y, Liu T, Wang Y, Li H et al.
Fibroblast activation protein-α (FAP) is an attractive cell surface target for radiopharmaceutical development due to its tumor-restricted expression. This study aimed to develop a novel dimeric FAP i…
Xiang J, Wen X, Wang R, Wang J et al.
Fibroblast activation protein (FAP) and integrin αvβ3 are attractive theranostic targets. We developed a dual-targeting radiotheranostic agent, 177Lu-DOTA-FAPI-RGD (177Lu-LNC1009), and conducted a fir…
Rezaei Borujerdi N, Rabani F, Saber Tanha A, Zare S et al.
We present a 55‑year‑old woman with adnexal masses and elevated CEA. Malignancy workup, adnexal biopsy, and intraoperative assessment revealed the appendix as the primary site, with pathology confirmi…
Jia G, Tian J, Cheng C, Zuo C et al.
Primary hyperoxaluria type 1 is a rare genetic disorder that leads to systemic oxalate deposition and end-stage renal disease. We describe 68 Ga-FAPI-04 PET/CT findings in a case of primary hyperoxalu…
Zhou L, Zhang S, Liu W, Lei Q et al.
An 80-year-old man underwent 18F-FDG PET/CT and 68Ga-FAPI PET/CT for a biopsy-confirmed metastatic gastrointestinal stromal tumor (GIST). While 18F-FDG PET/CT revealed intensely increased uptake in th…
Wu C, Kurniawan A, Li G, Ming Z et al.
Fibroblast activation protein-targeted radionuclide therapy (FAP-TRT) shows promise across multiple cancers, but clinical responses remain variable. Here, we aim to investigate how the presence, abund…
Chen D, Lou Y, Lin W.
We report ¹⁸F-FAPI-04 PET/CT findings of thoracic duct infiltration by tumor in a 61‑year‑old man with advanced gastric adenocarcinoma. The patient underwent ¹⁸F-FDG PET/CT for initial staging. Subseq…
Yan Y, Liu X, Jiang Y, Sun L.
Radionuclide drug conjugates (RDCs) are emerging molecular platforms for diagnostic imaging, targeted radionuclide therapy, and precision-oncology theranostics. Theranostic applications typically empl…
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