I-131 thyroid-cancer ablation evidence — activity selection, recurrence imaging, hospital-discharge practice. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Camilla Mazzoni, Lisa Argnani, Davide Di Benedetto, Sofia Maria Bakken et al.
The differential diagnosis of suspected neoplastic disease involving deep lymph nodes remains challenging, particularly in the abdomen, where biopsies are technically more complex and associated with higher procedural risks. The present retrospective single-center study aimed to evaluate the feasibility, safety and diagnostic accuracy of ultrasound-guided needle biopsy in patie…
This sequential mixed methods study explored experiences and perceptions of perfectionism in a sample of secondary aged children and adolescents. Phase 1 assessed the relationship between different domains of perfectionism and depression and anxiety in 114 pupils reporting high levels of perfectionism aged between 11-15 years (M= 12.73) attending six secondary schools in two En…
Accurate estimates of food and nutrient elasticities are important inputs for the design of efficient policies targeting the poor.In this paper we estimate the expenditure elasticity of food and calories using exogenous variation in budget from two unconditional cash transfer programs in rural Kenya, combined with detailed data on food expenditure, nutrition and prices.We find …
Introduction Nearly half of adults struggle to understand written health information, making medical communication a persistent barrier to effective care. While artificial intelligence has potential to improve health communication, few patient-facing tools have undergone systematic validation for personalized medical explanation. Methods Patiently AI is a mobile application des…
Organoids have become a central but contested notion across developmental biology, stem cell research, tissue engineering and regenerative medicine. I argue that the term organoid functions not as a single, well-defined scientific kind but as a special kind of patchwork concept that I call looping patchwork concept : a coordination device whose stability depends on overlapping …
Background Predictors for the successful eradication of neutralizing anti-FVIII alloantibodies (inhibitors) in hemophilia A patients receiving immune tolerance induction (ITI) therapy remain limited. Maternal microchimerism (MMc) showed potential to protect hemophilia A patients from inhibitor development. Objectives To investigated the role of MMc in ITI therapy. Patients/Meth…
Aitana Fernández‐Sogorb, María Pérez‐Marco, Carolina Gonzálvez, Christopher A. Kearney
In the school environment, students repeatedly engage in social interactions that enhance their development of social competencies. School attendance problems (SAPs) may disrupt these experiences and are associated with difficulties in social functioning. The present study examined the relationship between SAPs and two distinct dimensions of social functioning: social problems …
Diabetes mellitus (DM) is a systemic metabolic disorder characterized by chronic hyperglycemia, which can affect the kidneys, retina, peripheral nerves, and cardiovascular system, ultimately leading to multiple chronic complications. Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor activated through canonical cleavage, such as thrombin-mediated cleavage, and…
Haojun Chen, Liping Liu, Lijun Huang, Jie Huang et al.
Background Hypervirulence-associated carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) is a major clinical and public health threat. However, ST11-KL64 hv-CRKP co-harboring bla KPC-2 and bla NDM-13 remains poorly characterized, particularly regarding genomic relatedness, plasmid dynamics, and attenuated virulence-associated phenotypes. Methods We retrospectively investigated…
BACKGROUND AND PURPOSE: Although it has been assumed that higher physical activity (PA) levels will contribute to better physical fitness (PF) performance, the interplay between these two has yet to be investigated. Moreover, the majority of studies have been presented in children and adolescents, and older adults, while little is known about the correlation in the adult workin…
Marta Kamińska, Maja Chrobak, Lucas Sathler Alves Silva, Yasmin Gurtler Pinheiro de Oliveira et al.
Abstract We assessed cross-sectional relationships of rheumatoid arthritis (RA) disease activity and cardio-metabolic comorbidities with serum peptidylarginine deiminase 4 (PAD4)-potentiating activity, domain-resolved angiotensin I converting enzyme (ACE1) enzymatic activity, and Porphyromonas gingivalis -specific antibodies. 177 RA patients and 147 healthy controls (HC) were i…
Fatih Ekinci, Nur KAYA, Zeyneb Sude ALACA, Berfin TÜRKOĞLU et al.
Accurate prediction of ion-induced energy deposition in polymeric materials is essential for space radiation shielding and advanced radiotherapy applications. This study proposes a generalizable machine learning framework for predicting Bragg peak characteristics using Monte Carlo simulation. Energy deposition profiles were generated via SRIM/TRIM and Geant4 for ions with atomi…
Zuzana Višňovcová, Nikola Ferencová, Igor Ondrejka, Igor Hrtánek et al.
Abstract Background Adolescents with major depressive disorder (MDD) are associated with significant emotional dysregulation, yet objective physiological biomarkers remain elusive. While traditional electrodermal activity (EDA) measures provide a window into sympathetic arousal, the utility of spectral and nonlinear EDA analysis in characterizing adolescents with MDD is not wel…
Ahmed H. Madkour, Rania R. abdelaziz, Manar A. Nader, Mahmoud Elshal
Abstract Epileptogenesis is increasingly recognized as a multifactorial process driven by persistent neuroinflammation, oxidative stress, and dysregulated intracellular signaling, highlighting the need for therapeutic strategies that extend beyond symptomatic seizure control. The present study investigated the potential effects of prophylactic carvedilol administration on behav…
By Australian Society of Plastic Surgeons. Abstracts from the Australian Society of Plastic Surgeons Plastic Surgery Congress 2026, highlighting advancements and research in plastic, reconstructive and aesthetic surgery techniques.
Kath Williamson, Eleanor Grieve, Mike Lean, David N. Blane
Background: Few data exist on bariatric equipment and housing adaptations prescribed by occupational therapists and used by community-dwelling people with severe obesity (PwSO; body mass index (BMI) ⩾ 40 kg/m 2 ). This study aimed to document the use and costs of equipment and home adaptations by community-dwelling PwSO. Methods: An observational, cross-sectional study was cond…
Allison Loan, Lauren M. Bradford, Andrée Nunnikhoven, Gong Zhang et al.
Immunotoxicity has emerged as a key health concern for per- and polyfluoroalkyl substances (PFAS), with animal studies showing reduced T-dependent antibody responses (TDAR) and epidemiological studies reporting decreased vaccine antibody titres. Notably, immunotoxicity is considered one of the most sensitive endpoints for PFAS exposure and has been used to inform regulatory gui…
Adelia Kamenetskiy, Jami M. Furr, Aileen Herrera, Leah Feinberg et al.
Abstract Family accommodation is a key environmental factor that can maintain and reinforce child anxiety disorders, but research on accommodation specific to childhood selective mutism (SM) is limited and inconsistent. The absence of a supported measure of accommodation specifically in verbal contexts may explain, in part, why research on accommodation in the families of youth…
Abstract Objectives Peripheral inflammatory markers are frequently elevated in schizophrenia, but the extent to which inflammatory indices at acute relapse are associated with preceding antipsychotic treatment coverage remains unclear. We examined whether 6-month treatment coverage patterns—long-acting injectable (LAI) monotherapy, regular oral monotherapy, or no antipsychotic …
Agnieszka Musial, Andrea G. Allegrini, Rosa Cheesman, Angelica Ronald et al.
Abstract A combination of genetic and environmental factors working in interplay is thought to underlie differences in symptoms of psychopathology between adolescents. Yet, studies that have investigated gene-environment interaction in isolated aspects of developmental psychopathology lack robust effects, highlighting the need for a broader approach. We adopted a multivariable …
John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner, Lucinda Fitzgibbons et al.
Aging-associated inflammation, or 'inflammaging" is a driver of multiple age-associated diseases. Cyclic GMP-AMP Synthase (cGAS) is a cytosolic DNA sensor that functions to activate interferon response upon detecting viral DNA in the cytoplasm. cGAS contributes to inflammaging by responding to endogenous signals such as damaged DNA or LINE1 (L1) cDNA which forms in aged cells. …
Jinmin Shi, Shaimaa Abdel-Ghany, Mariam Abdel-Fattah, Xuebo Hu et al.
Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming-losing large lipid droplets, adopting fibroblast-like features, and intensifying lipolysis-while releasing proinflammatory mediators that accele…
Abstract Amyotrophic lateral sclerosis (ALS), is a global disease that is a leading cause of neurodegenerative condition that affects motor neurons. However, the etiology of ALS remains poorly understood. The genes responsible for the pathogenesis of ALS have not been fully identified. The present study aimed to explore new genes of ALS by mining the ALS RNA sequencing data. RN…
Abstract Parent–adolescent sexual communication is an established protective factor for adolescent sexual health. However, the specific family-level antecedents predicting these conversations remain poorly understood. Using longitudinal Adolescent Brain Cognitive Development (ABCD) data ( N = 4,593), we examined how family Cohesion, Conflict, Expressiveness, and Intellectual-Cu…
Somayeh Shamlou, Hossein Rostami, Ali Hassanzadeh, Simin Rajaeian et al.
Background: Degenerative diseases place an immense burden on global healthcare. Stem cell-based regenerative medicine offers transformative, potentially curative therapies to restore damaged tissues and recover normal physiological function. Aim: This review aims to comprehensively evaluate the therapeutic applications, biological mechanisms, and clinical prospects of stem cell…
Cuiling Zhang, Lijun Zhang, Shuping Zhao, Yanyan Huang et al.
Objective To evaluate the association of high-intensity focused ultrasound (HIFU) combined with syndrome differentiation-based individualized traditional Chinese medicine (TCM) herbal therapy with 12-month clinical outcomes compared with HIFU monotherapy in patients with adenomyosis (AM). Methods This prospective non-randomized, patient-preference, parallel-controlled study enr…
Background Pediatric wheezing diseases are linked to the risk of progression to persistent wheezing or asthma, particularly in cases with chronic airway inflammation and genetic predisposition. Early identification of high-risk children is crucial for timely intervention, yet the recovery phase of wheezing episodes, a transitional period, is often overlooked. Methods We integra…
Rongfang Shen, Huiting Yang, Xiaoting Ye, Ziqing Li et al.
Background: In the current conventional recombinant human thyrotropin (rhTSH) protocol, radioiodine therapy (RAIT) is given at 24 h post-second injection and diagnostic 131 I whole-body scan (Dx-WBS) at 72 h; hence, Dx-WBS cannot precede RAIT within the same two-injection cycle. This study aimed to evaluate whether Dx-WBS could be performed within 24 hours after the second inje…
Delayed graft function (DGF) remains a significant complication following deceased donor kidney transplantation. This study aimed to develop and validate a multidimensional machine learning model for predicting DGF by integrating clinical data, machine perfusion parameters, donor scores, and histopathological scores. A retrospective analysis was conducted on 961 deceased donor …
İsmail Yiğitdöl, Fatih Colkesen, Mehmet Emin Gerek, Ümmügülsüm Yılmaz Ergün et al.
Background Common variable immunodeficiency (CVID) is the most common clinically significant primary antibody deficiency in adults, characterized by impaired immunoglobulin production and recurrent infections. Endocrinopathies represent a substantial burden in inborn errors of immunity, with reported prevalence rates of approximately 27–32.5%. Existing literature on CVID has fo…
Bacteriophages, the viruses that infect gut bacteria, are now seen as active members of the intestinal ecosystem rather than passive observers. In type 2 diabetes mellitus (T2DM), growing evidence suggests that the gut phage community changes in several important ways. People with T2DM often have lower phage diversity, more temperate phages, and shifts in bacterial hosts. These…
Tongnian Wang, Carolina Vivas-Valencia, Cici Bauer, Yanmin Gong et al.
Abstract Persistent low retention and completion rates in medications for opioid use disorder (MOUD) have driven the use of machine learning (ML) models to predict retention and identify patients at risk of premature discontinuation. However, the fairness of these models across patient populations remains largely unexplored, raising concerns about their application in treatment…
Jiliu Huang, Weibo Zhou, Wen Tan, Fulin Zhou et al.
Background Orthopedic surgeons may underestimate the thrombotic risks associated with isolated muscular calf vein thrombosis (IMVT) and its influence on postoperative outcomes. This retrospective cohort study aimed to explore the impact of preoperative IMVT on perioperative safety and clinical efficacy of open reduction and internal fixation (ORIF) for Schatzker type II and III…
Lihui Liu, Honglin Chen, Jingxiao Wang, Jingjing Yang et al.
Most patients with cancer are older adults living with several other chronic illnesses, and both the tumour and its commonest companions—cardiometabolic disease, type 2 diabetes and depression—are sustained by a shared, immunosuppressive inflammatory milieu. In this setting many tumours are immunologically “cold”: poorly infiltrated by cytotoxic T and natural killer (NK) cells,…
Luigi Rosa, Aurora Bettini, Giulia Matusali, Licia Bordi et al.
Introduction Monkeypox virus (MPXV) infection induces robust humoral immune responses; however, the kinetics of IgG avidity maturation following natural infection remain poorly characterized. Since IgG avidity reflects antibody affinity maturation over time, its evaluation may provide additional information for the interpretation of MPXV serology and infection staging. This stu…
Xin Ge, Yuhui Sheng, Ruijie Gong, Suping Wang et al.
Background Habitual snoring is a common symptom in primary care but is often overlooked as a minor nuisance. Although sleep-disordered breathing has been associated with adverse health outcomes, the association between self-reported habitual snoring and health-related quality of life (HRQoL) remains insufficiently characterized among adults attending community health centers in…
Nelly Patricia Acosta-Ortiz, Marieta Magdalena Carrillo, Alex Israel Núñez, Verónica-Alexandra Melo-López
Introduction Oral language is essential to children's cognitive, social, and academic development. This study evaluated changes in oral language after the application of stimulation strategies in children aged 3–5 years enrolled in Early Childhood Education. Methods A quantitative, longitudinal, quasi-experimental single-group pretest-posttest design was used. The sample compri…
Nola Rahmadasmi, Oryza Sativa Fitriani, Yurista Yalda
Usnic acid is one of the secondary metabolites found in lichens. Usnic acid has anti-inflammatory activity and is classified as class 2 in the Biopharmaceutical Classification System (BCS), with low solubility but high permeability. Therefore, a suitable delivery system is needed to enhance the release and penetration of usnic acid through the skin. Propylene glycol is a common…
Humans are capable of extraordinary things thanks to the muscles, degrees of freedom and the central nervous system. Understanding how the brain selects motor control strategies in healthy and clinical populations is paramount to advancing our knowledge and better treat neuromuscular diseases. Historically, neuromuscular modelling approaches can be categorised into three groups…
Gene therapy represents a crucial frontier in modern medicine for brain diseases; however, a significant obstacle hinders its progress. The immense difficulty of therapeutic molecules that deliver to the brain should be in a safe and effective way. The challenge is that blood brain barrier (BBB) blocks most drugs from entering. Exosomes offer a powerful solution to this problem…
Objectives: This doctoral thesis evaluates the impact of mechanical alignment (MA) and functional alignment (FA) in total knee arthroplasty (TKA) on frontal ankle alignment. Through a retrospective comparative design, radiographic parameters, clinical findings, and patient-reported outcome measures (PROMs) were analyzed to identify distal biomechanical adaptations and assess th…
This doctoral thesis investigates Hp infection as a modifiable determinant of health, focusing on its carcinogenic role and on the potential of Hp control to reduce the burden of gastric cancer. The overarching aim is to explore the feasibility and effectiveness of workplace-based Hp screening, where occupational health surveillance is a unique, structured, and underutilized op…
Huda Basaleem, Fares M. S Muthanna, Awsan Bahattab, Khaled Al‐Sakkaf et al.
Abstract Background Patient safety competencies remain insufficient among health sciences graduates, especially in conflict-affected areas. This study assessed perceptions and attitudes toward patient safety among undergraduate medical students at the University of Aden, Yemen. Methods A cross-sectional descriptive study was carried out in June 2023 using a validated self-admin…
Yunhan Yang, Yanping Li, Roselyn S. Dai, Canping Chen et al.
DNA double-strand break (DSB) repair via homologous recombination (HR) is critical for maintaining genomic integrity and requires proper DNA end resection to generate single-stranded DNA (ssDNA) overhangs. However, the mechanisms governing this critical step in cells remains poorly understood. Here, we report that GNL3, a nucleolar GTP-binding protein, plays a key role in HR re…
Fibrosis is the outcome of chronic diseases and manifests as an abnormal repair process in which normal parenchyma is progressively replaced by deposited extracellular matrix. It leads to organ dysfunction and is associated with high morbidity, disability, and mortality, thereby becoming a major public health concern. Traditional Chinese medicine shows multi-target, multi-pathw…
Pontes MLS, Verçosa AFA, Lima MCL, Assumpção LVM et al.
Rationale and objectivesDifferentiated thyroid carcinoma (DTC) has a favorable prognosis when properly managed. Whole-body scanning (WBS) is the standard functional imaging method for post-surgical staging; however, its limited spatial resolution may lead to misclassification of iodine-131 (131I) uptake sites. Single-photon emission computed tomography/computed tomography (SPEC…
The present study focused on the development and application of LC-MS/MS methodologies for hormonal and metabolite profiling. The project pursued four objectives: optimization of LC-MS/MS protocols for the quantification of extended exogenous and endogenous steroid panels in dried blood spots (DBS); analysis of DBS samples for a broad steroid panel using an internal calibration…
Abstract Neuroinflammation is no longer a secondary feature of amyotrophic lateral sclerosis (ALS), but rather a disease-modifying process that actively shapes the motor neuron vulnerability from the earliest stages of pathology. Central and peripheral immune cells, including microglia, astrocytes, and infiltrating T lymphocytes, adopt context-dependent states that can be neuro…
Maria Eduarda Beckman Miranda, Ana Paula Sérvio Sousa, ORNIVANIA GOMES DE SOUSA MELO, Ana Patrícia dos Santos Silva et al.
A pandemia de COVID-19 impactou significativamente os sistemas de saúde, especialmente as unidades de terapia intensiva (UTI), exigindo reorganização dos serviços e fortalecimento da atuação multiprofissional. Objetivou-se analisar a produção científica sobre a cooperação entre enfermagem, farmácia, fisioterapia, psicologia e serviço social em UTI durante a pandemia. Trata-se d…
MOYEGBONE J.E., E. O. Emurotu, E. E. Oronsaye, P. Onyema et al.
Myopia is one of the refractive errors and the most common global health issue amongst young people. Progressive myopia results in the elongation of the eyeball, and puts patients at risk of vision-altering conditions such as cataracts and glaucoma. Traditional method of mitigating myopia was simply correcting the refractive error using single-vision lenses, and this method is …
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