Theranostics · Literature Radar
Ga-68 SSTR imaging — neuroendocrine staging, PRRT eligibility and dosimetric pairing with Lu-177. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Imperiale A, Mouissi I, Huon M, Taïeb D.
Somatostatin receptor (SSTR) PET has become a central imaging tool in neuroendocrine tumors (NETs), with established roles in detection, staging, restaging, and selection of patients for peptide recep…
Bagasariya R, Parghane RV, Basu S.
Gastric metastases from neuroendocrine tumors (NET) are infrequently encountered. Commonly, locally advanced pancreatic NET can involve stomach resulting in inoperable presentation. We herein present …
Si X, Xu Y, Zhang K, Zheng L et al.
A 5-year-old boy underwent 18F-FDG PET/CT before the histopathologic diagnosis of neuroblastoma, revealing a metabolically active left adrenal primary tumor with metastases to the liver. Following res…
Chang J, Toliver B, Borbon LC, Sherman SK et al.
BackgroundContemporary gastroenteropancreatic neuroendocrine tumor (GEPNET) management guidelines recommend routine use of functional imaging preoperatively, but there are few data highlighting trends…
Marulanda-Corzo V, Farid M, Hill T, Haghdel A et al.
Somatostatin receptor type 2 is highly expressed in meningiomas and can be quantified using [⁶⁸Ga]Ga-DOTATATE PET. The Krenning score, originally developed for [¹¹¹In]In-octreotide scintigraphy, remai…
Garabedian N, Zaragori T, Tabouret E, Taillandier L et al.
Evidence supporting the efficacy and safety of [¹⁷⁷Lu]Lu-DOTATATE in refractory meningiomas derives mainly from small, single-center studies. The French national multicenter MELUTE study aimed to cons…
Piekarski E, Cottereau AS, Coriat R, Willems L et al.
Neuroendocrine tumors (NETs) are often associated with paraneoplastic features including carcinoid syndrome in up to 30% to 40% of cases. However, paraneoplastic thrombocytosis is a rare NET-associate…
Li S, Wang X, Zhang K, Wang W et al.
A 5-year-old boy with high-risk neuroblastoma underwent 68Ga-DOTATATE PET/CT as part of a clinical trial to assess treatment response after anti-GD2 immunotherapy. The scan showed symmetric increased …
Moody TW, Ramos-Alvarez I, Jensen RT.
This paper includes a summary of the main points of our recent presentation at the 2025 RegPep meeting in Washington, DC. In the invitation to make this presentation by the meeting organizers, we were…
Sridhar A, Behiri N, Klubo-Gwiezdzinska J.
The incidental thyroid uptake of radiolabeled ligands used in positron emission tomography/computed tomography (PET/CT) targeting cell-surface proteins is observed in up to 6% of all scans. While diff…
Li S, Maes J, Maes A, Rottey S et al.
Somatostatin receptor (SSTR)-targeted imaging and therapy are established approaches for neuroendocrine tumors, but accumulating evidence indicates that SSTRs are also expressed in various non-neuroen…
La Salvia A, Rossi RE, Paravani P, D'Ippolito E et al.
Background: Pulmonary neuroendocrine tumors (lung NETs) comprise a biologically heterogeneous group of neoplasms ranging from indolent typical carcinoids to more aggressive atypical carcinoids. Accura…
Liu Y, Li Y, Wan D, Yang J et al.
PurposeTo develop an evidence-informed imaging framework for gastric neuroendocrine neoplasms (gastric NENs) that separates pathological entity, gastric NET type, and grade and links imaging selection…
Chiaravalloti A, Schillaci O.
Somatostatin receptor positron emission tomography (SSTR PET) characterizes receptor expression and supports peptide receptor radionuclide therapy (PRRT) eligibility, whereas [18 F]fluorodihydroxyphen…
Xu J, Yu M, Wang J, Huang N et al.
Predicting response to somatostatin analogs (SSAs) in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) with liver metastases (LMs) remains challenging. This study aimed to develop and validate …
Piai A, Bordigoni B, Antunovic L, Busnardo E et al.
PurposeThe increased sensitivity of long-axial field-of-view (FOV) digital PET/CT systems enables potential reductions in administered activity and/or acquisition time with respect to standard-field-o…
Nieri A, Imperiale A, Urso L.
Lee L, Ito T, Jensen RT.
IntroductionSomatostatin receptors (SSTRs) have played a central role in all aspects of the management of neuroendocrine/endocrine neoplasms (NENs). This includes in diagnosis of NENs with the widespr…
Hou Y, Wang J, Dai Y, Xu Z et al.
We describe the imaging findings of a phosphaturic mesenchymal tumor arising in the left maxillary sinus in a 34-year-old woman with persistent hypophosphatemia and elevated parathyroid hormone levels…
Rosok D, Hautzel H, Bertram S, Umutlu L et al.
Hibernomas are rare benign tumors derived from brown adipose tissue that may mimic malignancy on imaging. We report a 21-year-old woman with multiple endocrine neoplasia type 1 (MEN1) undergoing seria…
Moin A, Solnes L, Rowe SP, Frankl J.
A 41-year-old man with grade 1, well-differentiated neuroendocrine tumor (NET) of the terminal ileum underwent initial staging with 68Ga-DOTATATE PET/CT. PET/CT images demonstrated focal uptake at the…
Sai H, Kuruma H, Okada A, Enei Y et al.
BackgroundNeuroendocrine differentiation in advanced prostate cancer is associated with aggressive behavior, resistance to androgen receptor pathway inhibition, and altered tracer expression. Although…
Ozturk Unsal I, Ucgul E, Unver CK, Dizdar N et al.
Background: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with highly variable biological behavior. Somatostatin receptor (SSTR)-based imaging with ⁶⁸Ga-DOTATATE PET/CT h…
Tang S, Lei Q, Liu Y, Liu Y et al.
A 54-year-old man with progressive small cell lung cancer underwent ¹⁸F-FDG and ⁶⁸Ga-DOTATATE PET/CT before radionuclide therapy. ¹⁸F-FDG PET/CT evaluated disease extent and identified metabolically a…
Gerdes R, Schittenhelm J, Singer S, Reischl G et al.
BackgroundRadioactively labeled somatostatin analogs (SSAs) are used in PET imaging of meningiomas due to the high expression of somatostatin receptor (SSTR) subtype 2. 18F-labeled SSTR-tracers offer …
Küper AT, Shiyam Sundar LK, Djaileb L, Roschlak J et al.
Somatostatin receptor (SSTR)-targeting radiotracers hold promise for theranostic applications in breast cancer (BC). This retrospective single-center study aimed to assess the proportion of SSTR-posit…
Vu KV, Otis HG, Brandmaier A, Osborne JR et al.
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor A, is emerging as a promising therapy for high-grade meningioma, an aggressive central nervous system tumor with limited…
Strosberg JR, Al-Toubah T, Haider M, El-Haddad G et al.
Limited data are available regarding somatostatin receptor (SSTR) expression in poorly differentiated extrapulmonary neuroendocrine carcinoma (NEC). Some retrospective series have reported strong SSTR…
Schwarz JL, Williams JK, Keutgen XM, Liao CY.
Radiolabeled somatostatin analogs are increasingly used in the diagnosis and treatment of neuroendocrine tumors. Diagnostic imaging with 68Ga-DOTATATE PET/CT has demonstrated the improved sensitivity …
David L. Chan, Sara Mokhtar, Elizabeth J. Bernard, Connie Diakos et al.
Accurate contouring for [68Ga]Ga-DOTATATE PET/CT in neuroendocrine neoplasms (NENs) is challenging because of variable physiologic uptake in the liver, spleen, and other organs. This complicates absol…
Christian A. Dascalescu, Felix L. Herr, R. Ebner, Victoria Fusch et al.
BACKGROUND: Purpose of this study is to evaluate the value of a routinely available baseline SSTR-PET imaging parameter, the Krenning score (KS), within integrated biomarker models for overall surviva…
童良前, Fengshuang Wu, Dong Huang, Wei Liu et al.
Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the opt…
Liu Y, Xu T, Yang H, Huang Z et al.
PurposeTo investigate the association between baseline NETPET score and prognosis in patients with neuroendocrine tumors (NETs) receiving [225Ac]Ac-DOTATATE therapy.MethodsThis retrospective study inc…
Li S, Liu M, Zhang B, Yang J.
A 5-year-old girl with high-risk neuroblastoma underwent surveillance 18F-FDG PET/CT. The scan revealed two metabolically silent lesions-one in the right retina and one in the brain-without abnormal 1…
Taggar M, Shamim SA, Jain R, Yadav SK.
68Gallium NODAGA-JR11, a somatostatin receptor (SSTR) antagonist, exhibits superior sensitivity in detecting hepatic metastases of neuroendocrine tumors compared with the agonist tracer 68Ga-DOTANOC P…
Ye T, Wen X, Wang R.
Phosphaturic mesenchymal tumor (PMT) is a rare cause of tumor-induced osteomalacia (TIO), often presenting with nonspecific symptoms and small tumor size, leading to diagnostic challenges. We report a…
Al-Adhami D, Abdlkadir AS, Abdlkadir NS, Ruzzeh S et al.
ObjectivesThis systematic review describes the spectrum, distribution, and etiologies of non‑target [68Ga]Ga‑DOTANOC‑avid lesions proven by histopathology or follow‑up to be unrelated to normal biodis…
Monnin P, Gnesin S, Damet J, Stritt N et al.
Diagnostic Reference Levels (DRLs) are benchmarks for optimizing radiation doses in medical imaging. This study establishes new national DRLs (NDRLs) for PET/CT examinations in Switzerland based on a …
Al Said AT, Rahman AA, Albadarneh LK, Oglat AA et al.
BackgroundPositron Emission Tomography/Computed Tomography (PET/CT) is a crucial imaging modality widely used for diagnosing and staging various cancers. Although patient weight is known to influence …
Imperiale A, Montanini F, Baltzinger P, Canu L et al.
PurposeTo determine how the somatostatin receptor (SSTR)-PET imaging phenotype in paragangliomas and pheochromocytomas (PPGLs) is driven by tumour location and underlying genetic background.MethodsThi…
Schweiger L, Santo G, Kronthaler A, di Santo G et al.
The management of treatment-refractory meningioma in patients with previous surgical resection and radiation therapy remains challenging due to the lack of effective systemic treatment options. Theref…
Kuhn A, Marulanda-Corzo V, Gardella J, Vu KV et al.
PET using established and emerging molecularly targeted radiotracers has become integral to the evaluation and management of brain tumors, providing biologic information that complements conventional …
Bagasariya R, Sonavane S, Basu S.
False-positive findings on molecular imaging can pose significant diagnostic dilemmas in oncological cases. We report an elderly woman with metastatic neuroendocrine tumor of unknown primary who under…
Hernandez-Felix JH, Golagha M, Jha A, Varghese D et al.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors of neural crest origin that exhibit wide clinical and biological heterogeneity. While surgical resection remains the only cu…
Simsir C, Yılmaz K, Kılıçkap S, Onur RM et al.
A 50-year-old man with weight loss and fatigue was diagnosed with a grade 2 liver-metastatic neuroendocrine tumor (NET). Dual-tracer molecular imaging was performed for staging and characterization. W…
AlBarakat MM, Althunibat I, Altawalbeh RB, Hasan S et al.
IntroductionPancreatic granulomas are uncommon and typically classified based on the presence or absence of caseation. Caseating granulomas are most often associated with tuberculosis, while non-casea…
Chen JW, Roach PJ, Pavlakis N, Bernard EJ et al.
BackgroundNeuroendocrine neoplasms (NENs) are often metastatic at diagnosis and show great variation in primary site and biological behaviour. Although PET is often used to image NENs, contouring is c…
Mok C, Chow W, Sabahi Z, Bernard EJ et al.
BackgroundThe use of peptide receptor radionuclide therapy (PRRT) is well established in the treatment of advanced or unresectable neuroendocrine tumours (NETs) after progression on somatostatin analo…
Deroose CM, Leupe H, Hicks RJ, Virgolini I et al.
Somatostatin receptor PET imaging is integral to the management of patients with neuroendocrine tumours (NETs), yet standardised criteria for therapy response assessment with the use of this modality …
Yin B, Wang X, Zhu W, Liu W et al.
BackgroundAccurate preoperative lymph node (LN) staging is critical for determining optimal surgical strategies in duodenal and pancreatic neuroendocrine neoplasms (DP-NENs). While both gallium-68-lab…
Shao X, Bregenzer CM, Wang J, Chen Y et al.
PurposeCarotid atherosclerosis is a risk factor for stroke and major adverse cardiovascular events (MACE) and is characterized by inflammation and calcification at different stages. Simultaneous asses…
Deroose CM, Ambrosini V, Hofland J, Kaltsas G et al.
Molecular imaging of the somatostatin receptor (SSTR) plays a key role in the management of patients with neuroendocrine neoplasms in general, and neuroendocrine tumours in particular. Over the last 2…
Herold A, Hajati A, Cao Y, Fialkowski KP et al.
ObjectivesTo explore magnetic resonance imaging (MRI) and gallium-68 ( 68 Ga)-DOTATATE positron emission tomography (PET) performance in the assessment of neuroendocrine liver metastases (NELMs) on a …
Luck S, Sathi N, Shaqra H, Mozayan A et al.
Background and purposeSchwannomas are a key diagnostic consideration in patients with enhancing extra-axial intracranial, skull base, and neck masses. While contrast-enhanced MRI is the diagnostic mai…
Ravada SK, Parghane RV, Deshmukh A, Shah M et al.
AimTo evaluate and compare the diagnostic performance of [68Ga]Ga-DOTA-FAPI-04 with [18F]F-FDG and [68Ga]Ga-DOTATATE PET/CT for detecting recurrent disease in patients with medullary thyroid carcinoma…
Tasevski S, Imperiale A, Treglia G, Albano D.
Background/Objectives: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that often expresses somatostatin receptors (SSTRs). While various PET radiopharmaceuticals were used, there is no un…
Sanwick AM, Haugh KN, Osborne DR, Dawson JW et al.
Neuroendocrine tumors (NETs) represent a clinically heterogeneous group of malignancies originating from neuroendocrine cells, with the potential to arise in nearly any organ system. Despite their rel…
Liu M, Hong R, Zhang Y, Yan X et al.
PurposeThis study aims to investigate the prevalence, pattern, physiological basis, and influencing factors of sympathetic ganglia uptake on [¹⁸F]AlF-NOTA-LM3 PET/CT.Methods[¹⁸F]AlF-NOTA-LM3 PET/CT im…
Leupe H, De Buyst SA, Dekervel J, Cleeren F et al.
PurposeFluorine-18-labeled somatostatin receptor (SSTR) tracers are increasingly adopted as an alternative to generator-produced gallium-68 compounds for imaging neuroendocrine neoplasms (NENs). While…
Fedrigo R, Harsini S, Murtha L, Solar Vasconcelos JP et al.
BackgroundPeptide receptor radionuclide therapy (PRRT) is an established treatment for somatostatin receptor (SSTR)-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), with eligibility d…
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