Ga-68 SSTR imaging — neuroendocrine staging, PRRT eligibility and dosimetric pairing with Lu-177. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the optimal interpretation criteria for distinguishing PPGL from non-PPGL lesions in clinically suspected adrenal or retroperitoneal masses remain undefined. This retrospective study eval…
Elshafie O, Bou Khalil A, Salman BH, Itkin BL et al.
ContextCatecholamine-secreting pheochromocytomas and paragangliomas (PPGLs) can be difficult to stabilize before surgery or during follow-up. Somatostatin receptor expression provides a rationale for octreotide therapy, but clinical evidence is limited.ObjectiveTo evaluate biochemical, clinical, hemodynamic, metabolic, and perioperative outcomes associated with octreotide treat…
The application of artificial intelligence (AI) in positron emission tomography (PET)-based internal dosimetry in radiopharmaceutical therapy (RPT), with an emphasis on the paradigm shift from resource-consuming multi-time-point acquisition protocols toward efficient data-driven dosimetric frameworks. Machine learning (ML) models capable of determining organ- and patient-specif…
Leonardo Lampertico, Gaia Muti, C. Carbonini, Chiara Romanò et al.
The accuracy of quantitative lutetium-177 single-photon emission computed tomography/computed tomography (¹⁷⁷Lu SPECT/CT) depends on the imaging system, acquisition protocol, reconstruction algorithm, and calibration strategy. This study aimed to develop and evaluate a practical commissioning workflow to optimize ¹⁷⁷Lu imaging across different commercial scanner–reconstruction …
Koki Irie, Kunihiro Sasaki, Koichiro Furukawa, Ruizhi Jiajue et al.
Abstract Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). Burosumab, an anti-FGF23 antibody, is used for the management of TIO. However, burosumab therapy significantly elevates serum intact FGF23 levels, rendering preoperative systemic venous sampling unreliable. This report aims to evaluate the half-…
Nationwide real-world data on neuroendocrine tumors (NETs) remain limited in Japan because of their heterogeneous clinical presentation and indolent disease course. Over the past decade, treatment strategies for NETs have expanded substantially, encompassing somatostatin analogs, molecular targeted agents, cytotoxic chemotherapy, and radioligand therapy. Large-scale administrat…
Florence M. Muller, Margaret E. Daube-Witherspoon, Michael J. Parma, Amy E. Perkins et al.
BACKGROUND: Accurate attenuation correction (AC) is essential for quantitative positron emission tomography (PET). Conventional CT-based AC provides reliable attenuation (μ-) maps but adds radiation, introduces PET/CT misalignment artifacts, and is unavailable on stand-alone PET systems. Existing deep learning (DL) methods use non-attenuation corrected (NAC) PET data to predict…
A 5-year-old girl with high-risk neuroblastoma underwent surveillance 18F-FDG PET/CT. The scan revealed two metabolically silent lesions-one in the right retina and one in the brain-without abnormal 18F-FDG uptake. Subsequent 68Ga-DOTATATE PET/CT demonstrated intense to moderate, focal radiotracer accumulation in both lesions, consistent with somatostatin receptor expression. O…
68Gallium NODAGA-JR11, a somatostatin receptor (SSTR) antagonist, exhibits superior sensitivity in detecting hepatic metastases of neuroendocrine tumors compared with the agonist tracer 68Ga-DOTANOC PET/CT. In the presented case of rectal neuroendocrine tumor, both tracers identified the primary lesion and regional lymph node involvement; however, NODAGA-JR11 PET/CT revealed mu…
Al-Adhami D, Abdlkadir AS, Abdlkadir NS, Ruzzeh S et al.
ObjectivesThis systematic review describes the spectrum, distribution, and etiologies of non‑target [68Ga]Ga‑DOTANOC‑avid lesions proven by histopathology or follow‑up to be unrelated to normal biodistribution or the primary SSTR‑expressing disease.MethodsPubMed, Web of Science, and Scopus databases were utilized to conduct a systematic search and were updated until May 31, 202…
Al Said AT, Rahman AA, Albadarneh LK, Oglat AA et al.
BackgroundPositron Emission Tomography/Computed Tomography (PET/CT) is a crucial imaging modality widely used for diagnosing and staging various cancers. Although patient weight is known to influence radiation dose, there is limited research on optimizing PET/CT protocols based on weight categories to minimize unnecessary exposure.ObjectivesThis study evaluates the effective do…
Imperiale A, Montanini F, Baltzinger P, Canu L et al.
PurposeTo determine how the somatostatin receptor (SSTR)-PET imaging phenotype in paragangliomas and pheochromocytomas (PPGLs) is driven by tumour location and underlying genetic background.MethodsThis retrospective study included 174 PPGLs from 91 patients who underwent [⁶⁸Ga]DOTATOC PET/CT. Lesions were classified according to their anatomical location (head-and-neck, thoraci…
Schweiger L, Santo G, Kronthaler A, di Santo G et al.
The management of treatment-refractory meningioma in patients with previous surgical resection and radiation therapy remains challenging due to the lack of effective systemic treatment options. Therefore, novel therapeutic applications, such as peptide receptor radionuclide therapy (PRRT) targeting somatostatin receptors, may offer a promising therapeutic strategy. We aimed to …
Hernandez-Felix JH, Golagha M, Jha A, Varghese D et al.
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors of neural crest origin that exhibit wide clinical and biological heterogeneity. While surgical resection remains the only curative option, many patients have unresectable or metastatic progressive disease and/or with uncontrolled secretion requiring alternative management strategies. Advances in genetic…
AlBarakat MM, Althunibat I, Altawalbeh RB, Hasan S et al.
IntroductionPancreatic granulomas are uncommon and typically classified based on the presence or absence of caseation. Caseating granulomas are most often associated with tuberculosis, while non-caseating granulomas are usually secondary to systemic conditions such as sarcoidosis. Idiopathic cases are rare and can pose a significant diagnostic challenge, particularly when mimic…
BackgroundThe use of peptide receptor radionuclide therapy (PRRT) is well established in the treatment of advanced or unresectable neuroendocrine tumours (NETs) after progression on somatostatin analogues (SSA), with randomised clinical trials such as NETTER-1 and NETTER-2 showing improvement in progression free survival (PFS) as well as tumour response [12, 13]. Current landma…
PurposeTo evaluate the diagnostic performance, quantitative characteristics, and clinical implications of Glucagon-Like Peptide-1 Receptor (GLP-1R) PET using 68Ga-exendin-4 in patients with indolent and aggressive insulinomas, and to refine its role in comprehensive disease assessment.MethodsIn this prospective study, patients presenting with hypoglycemia and fulfilling Whipple…
ObjectivesTo explore magnetic resonance imaging (MRI) and gallium-68 ( 68 Ga)-DOTATATE positron emission tomography (PET) performance in the assessment of neuroendocrine liver metastases (NELMs) on a per-lesion basis, with particular attention to the contribution of individual MRI sequences and assessment of other factors that might influence their detection.Materials and metho…
Background and purposeSchwannomas are a key diagnostic consideration in patients with enhancing extra-axial intracranial, skull base, and neck masses. While contrast-enhanced MRI is the diagnostic mainstay, its specificity can be limited, especially in small or atypical lesions. [68GA]DOTATATE PET/MRI and PET/CT, which target somatostatin receptor subtype 2 (SSTR2), represent a…
BackgroundGallium-68 (68Ga) is a PET isotope that is finding more use in the clinical setting as a PET diagnostic tool, for example 68Ga PSMA is widely used in the diagnosis of prostate cancer, and 68Ga dotatate for the diagnosis of neuroendocrine tumors. Current production is mostly performed using either 68Ge/68Ga generators or liquid targets containing 68Zn and irradiated wi…
In the last decade, fibroblast activation protein-α inhibitors (FAPIs), which target the cancer-associated fibroblasts of the tumour microenvironment, have become a topic of great interest. In oncology, FAPI PET/CT imaging has repeatedly demonstrated a higher lesion detection rate than other conventional imaging modalities such as CT or 18F-FDG PET/CT for several tumours. In so…
AimTo evaluate and compare the diagnostic performance of [68Ga]Ga-DOTA-FAPI-04 with [18F]F-FDG and [68Ga]Ga-DOTATATE PET/CT for detecting recurrent disease in patients with medullary thyroid carcinoma (MTC) and additionally evaluate their role for prognostication and theranostics in management of MTC.MethodsIn this prospective single-centre study, 56 patients with suspected rec…
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