Targeted alpha therapy — Ac-225 PSMA and DOTATATE clinical experience, supply and dosimetry. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Jinmin Shi, Shaimaa Abdel-Ghany, Mariam Abdel-Fattah, Xuebo Hu et al.
Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming-losing large lipid droplets, adopting fibroblast-like features, and intensifying lipolysis-while releasing proinflammatory mediators that accele…
Abstract Amyotrophic lateral sclerosis (ALS), is a global disease that is a leading cause of neurodegenerative condition that affects motor neurons. However, the etiology of ALS remains poorly understood. The genes responsible for the pathogenesis of ALS have not been fully identified. The present study aimed to explore new genes of ALS by mining the ALS RNA sequencing data. RN…
Background: Trophoblast cell surface antigen 2 (TROP2, encoded by TACSTD2) is a transmembrane glycoprotein overexpressed in multiple aggressive epithelial carcinomas. While antibody drug conjugates targeting TROP2 have achieved regulatory approvals, acquired payload resistance and systemic off-target toxicities limit sustained remissions. Radionuclide Drug Conjugates (RDCs) rep…
Somayeh Shamlou, Hossein Rostami, Ali Hassanzadeh, Simin Rajaeian et al.
Background: Degenerative diseases place an immense burden on global healthcare. Stem cell-based regenerative medicine offers transformative, potentially curative therapies to restore damaged tissues and recover normal physiological function. Aim: This review aims to comprehensively evaluate the therapeutic applications, biological mechanisms, and clinical prospects of stem cell…
Mengzhao Han, Haoran Huang, Yang Li, Lan Wang et al.
Ferroptosis connects disrupted iron handling, phospholipid peroxidation, and insufficient antioxidant defense with cardiovascular injury. Whether exercise can modify ferroptosis-related vulnerability in the heart and vasculature remains an important but incompletely resolved question. This mechanism-centered narrative review evaluates exercise-related evidence across cardiovasc…
Gene therapy represents a crucial frontier in modern medicine for brain diseases; however, a significant obstacle hinders its progress. The immense difficulty of therapeutic molecules that deliver to the brain should be in a safe and effective way. The challenge is that blood brain barrier (BBB) blocks most drugs from entering. Exosomes offer a powerful solution to this problem…
Lao H. Saal, Hina Dalal, Pei Meng, Christian Brueffer et al.
Background: Population-scale molecular profiling integrated into routine healthcare could accelerate biomarker discovery, validation, and implementation, but the feasibility and sustainability of such an approach have rarely been demonstrated prospectively. The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative was established to integrate prospective molecular prof…
Erythrocytes, commonly known as red blood cells (RBCs), constitute the most abundant cell type in vertebrate mammals. Due to their unique biological and physical attributes, RBCs have been the focus of extensive research in biomedical engineering. Methods have been developed to transform RBCs into adaptable carriers for molecular payloads, thereby extending their functional cap…
Hypoxia severely compromises memory function by initiating a cascade of pathological events, including heightened oxidative stress, impaired mitochondrial bioenergetics and deregulation of glutamate receptor and apoptosis-related protein expression. Current therapies are often insufficient to adddress the complex neurobiological damage caused by hypoxia, emphasizing the need fo…
Benedetta Manca, Lui Forni, Hendrik Booke, Sven Meuth et al.
Acute kidney injury (AKI) affects approximately 15% of all hospitalized individuals and nearly half of those admitted to intensive care units and is increasingly recognized as a systemic syndrome whose consequences extend well beyond structural and functional changes confined to the kidney. Experimental studies highlight the role of inflammation and accumulation of metabolites …
Eslam E. Abd El-Fattah, G. Ngai, Rachael Mooney, Karen S. Aboody
PURPOSE OF REVIEW: Obesity is a potent risk factor for cancer, primarily driven by a state of chronic inflammation. A key mechanism linking adipose tissue dysfunction to tumorigenesis is the induction of cellular senescence and the related Senescence-Associated Secretory Phenotype (SASP), which is not clearly defined. RECENT FINDINGS: In obesity, expanding adipose tissue become…
Justin Y. Lee, Chi Zhu, Melissa A. Boldridge, Rachelle L. Stark et al.
Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identified an orally bioavailable multi-functional small molecule,…
Epigenetics modulates gene expression and plays a pivotal role in numerous immune disorders. Over the past two decades, increasing evidence has indicated that epigenetic regulation contributes to transplant rejection and immune tolerance. Four primary epigenetic mechanisms—DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs (ncRNAs)—exert distinct …
Coronary artery bypass grafting (CABG) remains central for multivessel coronary artery disease, but durable benefit depends on graft patency. Patency reflects interacting anatomical, technical, haemodynamic, biological and patient-level determinants. The endothelium offers a useful, metabolically active interface because it regulates vascular tone, thrombosis, inflammation, leu…
Victoria Kiriaki Arnet, Cameron N. Johnstone, Richard P. Redvers, Caroline A. Chambers et al.
Triple-negative breast cancer (TNBC) has a high incidence of metastasis and limited therapeutic options. Here, we identify a multimodal and targetable miR-342-E2F network that regulates metastatic outgrowth in TNBC. Through integrating clinical and experimental datasets, we uncover miR-342 as a suppressor of TNBC metastasis. Temporal re-expression of miR-342 significantly inhib…
Introduction The notion of microtubule (MT) dynamics relates to the changes in the length of MT polymers in living cells. They are governed by a stochastic process related to the rates and chances of adding or removing tubulin dimers at the ends of MT polymers, termed dynamic instability. The ability of each MT to swiftly switch between stages of adding or removing dimers at th…
Background: Cardiovascular diseases (CVD) remain the primary cause of global mortality, necessitating innovative therapeutic approaches beyond traditional neurohormonal blockade and lipid-lowering therapies. Recent advancements have highlighted the gut microbiota as a dynamic endocrine organ that communicates with the host cardiovascular system via small molecule metabolites. W…
Kim May Lee, Ziyan Wang, Richard Emsley, Nigel Stallard
In most multi-arm randomized controlled trials, all participants need to be eligible to be randomized to all the arms. This means some participants are excluded from participating in multi-arm studies. We propose to relax this by considering a 'differential randomization' approach that allows the inclusion of participants who are eligible for some but not all arms, as in some i…
Asif Khan, Atta Ullah, Maira Gabriela Paetzold, Flávio Augusto Vicente Seixas
Abstract Caspase-1 is a key protease that regulates inflammation by mediating the maturation of pro-inflammatory cytokines IL-1β and IL-18 as well as inducing the pyroptotic cell death. Dysregulation in caspase-1 activity is implicated in various inflammatory, autoimmune and metabolic disorders. This review systematically analyzes natural, synthetic and computationally predicte…
Alexander Braunsperger, Dominik Tischer, Ana Soriano‐Arroquia, Martin Schönfelder et al.
Abstract Over the past 25 years, adipose tissue has emerged as an organ comprising nearly 20 major cell types, including three types of adipocyte subtypes: white, brown, and beige. White adipocytes primarily store energy, brown adipocytes generate heat through thermogenesis and beige adipocytes exhibit intermediate characteristics. Distinct adipose tissue depots vary in their r…
The application of artificial intelligence (AI) in positron emission tomography (PET)-based internal dosimetry in radiopharmaceutical therapy (RPT), with an emphasis on the paradigm shift from resource-consuming multi-time-point acquisition protocols toward efficient data-driven dosimetric frameworks. Machine learning (ML) models capable of determining organ- and patient-specif…
Introduction and Aim of the study: Colorectal cancer (CRC) is the second-leading cause of cancer deaths worldwide.During carcinogenesis, alteration of the gut epithelial barrier allows the translocation of gut bacteria to the tumor tissue and their interaction with immune cells.Infiltration by T cells is associated with improved survival, but their interplay with gut bacteria h…
The Journal of Urological Surgery is an open access, scientific, double-blind peer-reviewed journal in the field of Urooncology, Endourology, Pediatric Urology, Andrology, Reconstructive Urology, General Urology, Urogynecology and Functional Urology, Transplantation and Vascular Surgery. No fee is charged from the authors during the submission, evaluation and publication proces…
Huining Huang, Yao Yu, Qian Zhou, Guangtong Deng et al.
RNA splicing expands the functional output of eukaryotic genomes by enabling individual precursor messenger RNA (pre-mRNA) to generate multiple mature transcripts with protein‑coding and regulatory properties. Its fidelity and plasticity depend on coordinated interactions among the spliceosome, trans-acting splicing factors, cis-regulatory elements, and chromatin- and RNA-assoc…
Venous malformation (VM) is the most common subtype of vascular malformation. Due to the chronic nature of this disorder, VM patients face significant morbidity and complications throughout their lives. Current therapeutic options can be limited, but recent advances in understanding the cellular and molecular mechanisms that underly VM pathogenesis provide hope for the discover…
This thesis investigated the prevalence of Aggregatibacter actinomycetemcomitans and Filifactor alocis in Western Australian periodontitis patients, addressing a major gap in Oceanian data. A systematic review showed global presence of the JP2 genotype but no data from Oceania. In a cohort of 220 patients, Aggregatibacter actinomycetemcomitans was detected at low levels with no…
Qixiang Wu, Ying Hu, Yuhan Wang, Fuqiang Zhu et al.
The Piezo1 channel is a mechanosensitive, non-selective cation channel that converts mechanical forces into electrochemical signals, playing pivotal roles in vertebrate physiology. Structurally, Piezo1 features a distinctive trimeric propeller structure that undergoes conformational changes in response to membrane tension, enabling mechanogating. Accordingly, Piezo1 is involved…
Abstract Racial/ethnic microaggressions in educational settings are subtle daily manifestations of interpersonal racism that may communicate harmful messages and disrespectful behaviors toward students belonging to marginalized groups. Given the pivotal role of schools and universities in students’ emotional, cognitive, and relational growth, it is critical to thoroughly unders…
Hardik Mody, Jatin Narula, Prathap Nagaraja Shastri, Dale Miles et al.
Viral-based gene therapies and vaccines represent a rapidly evolving modality for treating a wide range of diseases. However, these novel modalities pose novel and complex challenges for translational PK/PD scientists and clinical pharmacologists during preclinical and clinical development. To support accelerated development of these transformative therapies, experts in the fie…
Graduating students often face the dual challenge of completing academic requirements and entering an uncertain labor market, yet limited research has examined the cognitive-affective factors involved in the association between academic stress and later employment anxiety. This study examined whether the association between academic stress and later employment anxiety included …
Protozoan parasites of the genus Leishmania, the causative agents of human leishmaniasis, have evolved mechanisms to manipulate host cell functions to their advantage. Recently, small non-coding RNAs have been identified as contributors to the pathogenesis of Leishmania infection. An increasing number of studies have demonstrated that Leishmania tRNA-derived small non-coding RN…
Igor Belenichev, Olena Popazova, Oksana Dmytriieva, Sergiy Chertov et al.
Periodontitis (P) is one of the most common human dental diseases, with significant medical and social implications. According to the World Health Organization, more than 45% of the adult population worldwide exhibits clinical signs of periodontitis, with 10%–15% of cases becoming generalized with destruction of the alveolar bone. This review presents the results of modern rese…
Wen Fang, Yihan Wang, Zhenyu Yang, Hongyun Zheng et al.
Cancer in older adults has become a significant public health challenge, with increasing incidence and limited efficacy of conventional treatments due to aging-related biological changes, such as chronic inflammation, immune decline, metabolic dysfunction, and cellular senescence. These alterations create a pro-tumor environment, weakening antitumor capacity and reducing treatm…
Mohammad Chand Jamali, Alaa Shafie, Ali Jaber Alqahtani, Rithab Ibrahim Al-Samawi et al.
Therapeutic approaches employing mesenchymal stem cells (MSCs) have emerged as a promising avenue for investigating treatments for neurological disorders. This strategy aims to capitalize on the biological properties of MSCs to support the repair of damaged neural tissue and modulate pathological processes. This review provides a comprehensive overview of the current clinical e…
Inass Shaltout, Mona Hegazy, Amr A. El Meligi, Shereen Abdelghaffar et al.
Abstract Background The global prevalence of obesity continues to rise, with 3 billion adults projected to be affected by 2030. Recent advances in anti-obesity pharmacotherapy, particularly incretin-based medications, have transformed obesity management. This consensus provides evidence-based guidelines for the clinical use of incretin-based obesity management medications (OMMs…
Жанибек Муратов, Aida Zotaj, Amina Kalandarova, Katarzyna Wiśniewska et al.
The deterioration of ambient air quality worldwide has intensified the need to examine the environmental factors associated with the growing burden of respiratory disease. This study aimed to identify broad patterns in the adverse effects of environmental exposures on the respiratory system, while accounting for regional variation and population-specific vulnerability. A system…
Ruohan Zhao, Huilin Xu, Yirui Zhu, Huailong Chang et al.
The gut-brain-skin axis is a proposed integrative framework describing interactions among the gastrointestinal tract, skin, and nervous system through neural, endocrine, immune, and microbial processes. Accumulating evidence has redefined the skin as a sophisticated neuro-immune-endocrine organ rather than a passive barrier, providing the fundamental mechanistic basis for the b…
Angelika Edyta Charkiewicz, Ivana Djuricic, Vanja Todorovic, Jacek Nikliński et al.
Following its discovery, radium was initially promoted as a therapeutic agent for a wide range of conditions, including skin disorders, allergies, visual problems, joint pain, and as a general health-enhancing remedy. However, subsequent research demonstrated its significant radiological toxicity and harmful effects on human health. Despite these risks, more than a century afte…
Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang et al.
Inflammatory bowel disease (IBD) is a group of chronic, relapsing and systemic inflammatory disorders primarily affecting the gastrointestinal tract, including Crohn's disease, ulcerative colitis and rarer distinct subtypes such as indeterminate colitis. IBD has shown a marked shift in global epidemiology, with increasing incidence in newly industrialized regions across Africa,…
This narrative review provides a comprehensive synthesis of mortality rates and associated risk factors among individuals with autism spectrum disorder (ASD) across the lifespan. Following a search across PubMed, Scopus, and Google Scholar, 31 peer-reviewed studies were identified for synthesis. The findings consistently demonstrate that individuals with ASD experience signific…
Babeker H, Nwangele E, Monzer A, Pougoue Ketchemen J et al.
PurposeMUC-16-targeted antibodies can deliver contrast agents (diagnostic) and/or cytotoxic payloads (therapy) to the tumor site. MUC-16 is overexpressed in 80% of epithelial ovarian cancer (EOC) and 65% of pancreatic ductal adenocarcinomas (PDAC). We previously developed a fully human antibody against MUC-16 (M16AB) and demonstrated the utility of [89Zr]Zr-DFO-M16AB as a PET i…
Hao Zhang, Yekuan Shi, Yanqin Yu, Zongxi He et al.
Abstract Objective Metastatic castration-resistant prostate cancer (mCRPC) remains associated with poor long-term outcomes, and survival under current treatment is modest. Prostate-specific membrane antigen (PSMA)-targeted alpha therapy using 225 Ac exhibits superior cytotoxicity compared with beta-emitting radiopharmaceuticals; however, dose-limiting xerostomia from salivary g…
PurposeTo investigate the association between baseline NETPET score and prognosis in patients with neuroendocrine tumors (NETs) receiving [225Ac]Ac-DOTATATE therapy.MethodsThis retrospective study included patients with NETs treated with [225Ac]Ac-DOTATATE between November 2021 and March 2025. All patients underwent [18F]F-FDG and [68Ga]Ga-DOTATATE PET within one week before tr…
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by the limited efficacy of current therapies and an urgent need for novel treatment strategies. Targeted radionuclide therapy (TRT) enables the selective delivery of radionuclides to tumor sites via specific ligands, integrating molecular targeting with cytotoxic radiation. Among …
Targeted alpha therapy (TAT) has the advantage of localized cytotoxicity using the high linear energy transfer capabilities of alpha particles. Actinium-225 ([225Ac]Ac) has been shown to be suitable for antibody-based targeting but lacks chelate stability and conjugation reproducibility. CD276 (B7-H3) has been shown to be broadly overexpressed in various solid tumors and thus p…
Adam DP, Yusufaly T, Marsh IR, Bastiaannet R et al.
Standard of care RPT may result in dose-limiting side effects of the salivary glands include sialadenitis and xerostomia that are inconsistent with outcomes from external beam for equivalent ADs. This work develops a parametrizable 'Macro-to-Micro' (M2μ) model that demonstrates the consideration of small-scale dosimetry in comparison to conventional methods that typically assum…
BackgroundTheranostics, integrating diagnostic imaging with targeted radionuclide therapy, has become central to nuclear medicine, but its global research landscape and collaboration patterns remain incompletely mapped.ObjectiveTo characterize publication dynamics, cooperative networks, and emerging topics in theranostic research from 2006 to 2024.MethodsArticles and reviews in…
Echigo H, Munekane M, Fuchigami T, Mishiro K et al.
Macropa has formed more stable complexes with 225Ac, although DOTA has been extensively used as a chelator for 225Ac. This study aimed to design and synthesize two novel 225Ac-labeled RGD peptides, [225Ac]Ac-Macropa-c(RGDyK) ([225Ac]1) and [225Ac]Ac-Macropa-[c(RGDyK)]2 ([225Ac]2), and to evaluate their potential for targeted alpha therapy (TAT) of glioblastoma. Further, whether…
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