📖 Free full textPeer-ReviewedOpenAlexORBi (University of Liège) · 2026
Expert Q&A: Biomarker Analysis in the Modern Lab
S Thiageswaran, Jean‐François Focant
peer reviewed
Radiotherapy QA · Literature Radar
Patient-specific QA — latest research
Pre-treatment verification — IMRT/VMAT gamma analysis, log-file QA, 3D dose reconstruction. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
📖 Free full textPeer-ReviewedOpenAlexPure Amsterdam UMC · 2026
Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review
Omar Dewidar, Mouad Elganga, Martin Ringsten, Miranda Langendam et al.
Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certainty of evidence (CoE) domains and evidence-to-decision (EtD) criteria. Study Design and Setting We c…
📖 Free full textPeer-ReviewedOpenAlexSri Lankan Journal of Applied Sciences · 2026
Large Language Models and Medical AI Systems for Healthcare Diagnosis: A Systematic Review
M. U. K. Gunawardhna, Pirunthavi Wijikumar, D. M. O. K. Weerasinghe
The rapid growth of artificial intelligence systems (AI systems) has increased interest in the use of patient care and clinical decision-making processes. There is some uncertainty regarding their reliability and safety in clinical practice. A more detailed systematic review of literature examining LLMs applied to healthcare diagnosis was conducted. A PRISMA-based systematic re…
📖 Free full textPeer-ReviewedOpenAlexTraumatology and Orthopedics of Russia · 2026
Cost-effectiveness analysis of patient-specific and standard vertebral body replacements in the surgical treatment of spinal tumors
Никита Заборовский, Sergei Masevnin, Д. А. Пташников, Р. М. Тихилов
Abstract Background. The widespread integration of patient-specific vertebral body prostheses is hindered by their high manufacturing costs. A comprehensive understanding of the long-term cost-effectiveness of additive manufacturing is required for informed decision-making in spine surgery. Objective. To evaluate the cost-effectiveness of patient-specific 3D-printed polyetheret…
📖 Free full textPeer-ReviewedOpenAlexDiscover Toxicology · 2026
Bisphenols perturb systemic iron homeostasis and fuel the pathogenesis of metabolic dysfunction-associated steatotic liver disease
Jing Xu, Hui Xu, Ruilin Qi, Yumiao Li et al.
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) arises from the interplay between environmental and nutritional factors. This review, from a novel “pollutant-nutrient-disease” perspective, systematically elucidates the core mechanisms by which bisphenols (BPs) exposure exacerbates MASLD through the disruption of iron homeostasis. Evidence in…
📖 Free full textPeer-ReviewedOpenAlex · 2026
Peer Review Report For: Supporting parents with psychosis in adult mental health services: protocol for a feasibility trial of the self-directed Triple P Positive Parenting Programme (The PIPPA study) [version 1; peer review: 1 approved with reservations]
Lynsey Gregg, Chris Sutton, Rory Allott, zach howarth et al.
Background Caring for children while experiencing psychosis can be difficult for parents, and their children risk poorer outcomes. Despite strong evidence for parenting interventions in the general population, it is not known if parents with psychosis find them acceptable or useful. This paper describes a study designed to investigate the feasibility and acceptability of conduc…
📖 Free full textPeer-ReviewedOpenAlexJournal of Applied Clinical Medical Physics · 2026
Clinical evaluation of novel deep learning‐based auto‐segmentation software: Utility and potential pitfalls
Ryota Tozuka, Masahide Saito, Masaki Matsuda, T. Akita et al.
BACKGROUND: Accurate contouring of target volumes and organs at risk is critical in radiotherapy. While deep learning (DL) models offer automated contouring, their clinical applicability to real-world cases containing anatomical variations and artifacts requires rigorous validation. PURPOSE: To evaluate the clinical accuracy and potential vulnerabilities of RatoGuide, novel DL-…
📖 Free full textPeer-ReviewedOpenAlexJournal of Applied Clinical Medical Physics · 2026
Beam geometry optimization and convergence mode evaluation for knowledge‐based planning of hippocampal avoidance whole‐brain radiotherapy: A cross‐platform study with quantitative scorecard assessment
Anh Lam, Kirk Luca, Mandeep Kaur, Keyur D. Shah et al.
BACKGROUND: Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) is used to treat brain metastases while preserving cognitive function by sparing the hippocampi. Volumetric modulated arc therapy (VMAT) is commonly used due to its ability to generate conformal dose distributions. However, treatment planning remains challenging due to the need for sharp dose fall-off near cen…
📖 Free full textPeer-ReviewedOpenAlexJournal of Applied Clinical Medical Physics · 2026
Log file‐based patient‐specific quality assurance for MR‐guided radiation therapy with comprehensive motion management
Kai Yuan, Matthew M. Cheung, Louis Lee
BACKGROUND: Patient-Specific Quality Assurance (PSQA) for Elekta Unity MR-Linac treatments delivered under Comprehensive Motion Management (CMM) is challenging because beam gating, unexpected interruptions, and split sub-segments introduce delivery complexities that are not fully addressed by conventional quality assurance workflows. PURPOSE: This study aimed to develop and eva…
📖 Free full textPeer-ReviewedOpenAlexInternational Immunopharmacology · 2026
Lipid droplet–mitochondria mismatch in atherosclerosis: From disrupted lipid routing to persistent inflammation and necrotic core expansion
Mingyang Gu, Yijun Qiu, Yao Wang, Jiongbo Xu et al.
Atherosclerosis (AS) is a chronic lipid-driven inflammatory disease of the arterial wall, and substantial cardiovascular risk persists despite intensive lipid-lowering therapy. Plaque progression depends not only on lipid entry, but also on how vascular wall cells handle intracellular lipids under sustained stress. Lipid droplets (LDs) temporarily sequester excess cholesteryl e…
📖 Free full textPeer-ReviewedOpenAlexJournal of Physics D Applied Physics · 2026
The harmonic residual index: a spectral purity metric for magnetic hyperthermia RF generators
Serhat Ilgaz Yöner, Alpay Özcan, Oğuz Akın
Abstract Background: RF generators are core components of magnetic hyperthermia (MH) systems, yet output quality is rarely characterized beyond nominal frequency and amplitude. Harmonic distortion can introduce parasitic components that complicate reproducibility and accurate field characterization; MH-specific spectral quality indices remain limited. Purpose: This study propos…
📖 Free full textPeer-ReviewedOpenAlexCognitive Computation · 2026
SFQSV Net: State Fusion Quantum Spectral Vision Network for Enhanced Elderly Fall Detection and Preventive Care in Smart Communities
Manoj Kumar, Tathagat Banerjee, Prachi Chhabra, Abhay Kumar et al.
Abstract A fall occurs when an individual loses balance and strikes the ground or a nearby object. This is a leading cause of accidental death among people aged 65 years and above, making it a universal health issue. Although fall detection systems have shown positive outcomes, detecting falls in varied environments remains challenging. We proposed the State Fusion Quantum Spec…
📖 Free full textPeer-ReviewedOpenAlexINTERNATIONAL JOURNAL OF COMPUTER SCIENCE AND MATHEMATICAL THEORY E-ISSN · 2026
A System-Level Power Behavior Model for Bluetooth and Wi-Fi Coexistence in Dual-Mode Wireless Devices
Robert Quainoo
Dual-mode wireless devices that implement Bluetooth and Wi-Fi in the same physical layer platform and share a single 2.4 GHz antenna must manage the mutual interference and power consumption that arise from concurrent operation of two radio systems in overlapping spectrum. The coexistence challenge encompasses both the RF interference dimension, where simultaneous Bluetooth and…
📖 Free full textPeer-ReviewedOpenAlexAIDS and Behavior · 2026
Illness Perception Clusters Moderated the Association Between HIV-related Stigma and Resilience in Mother–Child Dyads Living with HIV: An Actor–Partner Interdependence Moderation Approach
Chenxi Wang, Shiyun Ji, Siya Chen, Xiaoliang Zeng et al.
Illness perceptions (beliefs about illness identity, impact, understanding, and control) are connected with clinical and psychological outcomes. According to the relationship-oriented model of HIV-related stigma, stigma affects individuals and their significant others. Among mothers living with HIV and their children with perinatally acquired HIV (PHIV) who experience stigma, a…
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Public Health · 2026
Drone-delivered automated external defibrillators in prehospital emergency care: implementation evidence, bottlenecks, and conceptual integration with artificial intelligence and next-generation communications
Hua Li, Yunxiao Zhao, Wenkai Guo, Ning Luo et al.
Out-of-hospital cardiac arrest (OHCA) remains a major global health challenge. Survival depends on immediate cardiopulmonary resuscitation and early defibrillation. Static public-access defibrillator programs often fail to reach private, rural, or otherwise underserved locations. Drone-delivered automated external defibrillators (AEDs) may overcome ground-traffic and geographic…
📖 Free full textPeer-ReviewedOpenAlexInsights into Imaging · 2026
Technical challenges in establishing local native T1 reference ranges in cardiac MRI: a critical review
Maheran Che Ha’, Khairil Amir Sayuti, Yusri Mohammed, Mardhiyati Mohd Yunus et al.
Establishing local reference ranges for native T1 in healthy myocardium is critical in cardiac magnetic resonance imaging (CMR) for the accurate detection of myocardial fibrosis and other tissue abnormalities. However, native T1 measurements vary widely and are sensitive to technical factors such as the magnetic field strength, static magnetic field (B0) and radiofrequency (B1)…
📖 Free full textPeer-ReviewedOpenAlexThe Egyptian Journal of Internal Medicine · 2026
Firsekibart for gouty arthritis: a review of clinical efficacy, safety, and therapeutic positioning
Gao-Yi Yi, Hong-Mei Diao, Qiang Zhou, Liu Xiu-qiong et al.
Abstract Introduction Gout is the most prevalent inflammatory arthritis worldwide, yet conventional treatments—non-steroidal anti-inflammatory drugs, colchicine, and glucocorticoids—are limited by efficacy ceilings, safety concerns, and contraindications in patients with renal impairment or cardiovascular disease. Firsekibart, a novel fully human anti-interleukin-1β monoclonal …
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Medicine · 2026
Cost-effectiveness analysis of eltrombopag, hetrombopag and romiplostim for second-line treatment of primary immune thrombocytopenia in China
Xi Chen, Yadi Liu, Jianping Zhang, Rong Xu et al.
Background Primary immune thrombocytopenia (ITP) is a chronic autoimmune bleeding disorder requiring long-term second-line treatment in patients refractory to corticosteroids and immunoglobulins. In China, eltrombopag, hetrombopag, and romiplostim are all available after national reimbursement negotiations, but comparative economic evidence to inform optimal therapeutic selecti…
📖 Free full textPeer-ReviewedOpenAlexJournal of Veterinary Diagnostic Investigation · 2026
From accuracy to service: deciding what artificial intelligence outputs may do in veterinary diagnostic laboratories
Cleverson D. Souza
Artificial intelligence (AI) tools are entering veterinary diagnostic laboratory service, but reported model accuracy does not determine what the laboratory staff should allow an output to do. This Commentary defines service entry as the point at which an AI output is allowed to influence case triage, interpretation, a draft report, or result release. Before that point, the lab…
📖 Free full textPeer-ReviewedOpenAlexFigshare · 2026
Post-procedural access blood flow and repeat endovascular intervention in hemodialysis vascular access: a recurrent-event cohort study
Hong‐Mou Shih, Cheng-Jui Lin, Shih-Ming Chuang (24137634), Kuei-Shan Chang et al.
The prognostic value of access blood flow (Qa) measured after endovascular intervention is uncertain. We performed an episode-based recurrent-event cohort study of maintenance hemodialysis patients undergoing endovascular intervention for arteriovenous access dysfunction. The primary exposure was post-procedural Qa modeled continuously per 100 mL/min higher Qa; post-procedural …
📖 Free full textPeer-ReviewedOpenAlexnpj Digital Medicine · 2026
Towards a multi-agent Clinical Trial Center framework to support modern clinical trials
Bjorn Redfors, Weishen Pan, Chen Lyu, Mario Gaudino et al.
Abstract Clinical Trial Centers (CTCs) manage complex multi-site trials under rising regulatory and operational demands. Traditional workflows are labor-intensive and error-prone. Existing AI handles narrow and siloed tasks. We introduce Agent System for TRial Automation (ASTRA), a proposed multi-agent CTC in which a central Coordinator Agent and site-level Agents orchestrate d…
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Oncology · 2026
Integrating clinical and economic outcomes in the elderly myeloma management: a comparative cost-effectiveness analysis
Antonio G. Solimando, Vanessa Desantis, Lucia Di Marzo, Giulia De Martino et al.
Introduction Multiple myeloma (MM) is a hematologic malignancy that predominantly affects older adults and poses substantial therapeutic challenges due to the high prevalence of comorbidities and limited treatment tolerability. This study evaluates the cost-effectiveness of four first-line treatment regimens for elderly MM patients, ineligible for autologous stem cell transplan…
📖 Free full textPeer-ReviewedOpenAlexJournal of King Saud University - Computer and Information Sciences · 2026
Collaborative explainable ai for EEG mental health monitoring with constrained QA-Tuned LLM alignment
Zian Ding, Fusen Guo, Zhibo Zhang, Zhibo Zhang et al.
The monitoring of mental health states using electroencephalogram (EEG) signals has gained increasing attention due to its non-invasive nature for psychological disorders. Large Language Models (LLMs) and Explainable Artificial Intelligence (XAI) have been utilized in advancing the intelligence and interpretability of EEG analysis. However, existing methods face critical bottle…
📖 Free full textPeer-ReviewedOpenAlexJournal of Pharmaceutical Innovation · 2026
Integrating Business Impact Analysis, Scenario-Based FMEA, and Business Continuity Planning in Pharmaceutical Manufacturing: A Product-Level Case Study
Ivana Mitrevska, Sandra Boshnachki, Sonja Burcevska, Elizabeta Karadžinska et al.
This study evaluated the product-level integration of Business Impact Analysis (BIA), scenario-based Failure Mode and Effects Analysis (FMEA), and Business Continuity Planning (BCP) for a selected finished medicinal product. A single-site case study was conducted for cefixime 400 mg film-coated tablets in a GMP-regulated pharmaceutical organization. Data were collected over app…
📖 Free full textPeer-ReviewedOpenAlexbioRxiv (Cold Spring Harbor Laboratory) · 2026
De novo Design of Macrocyclic Molecular Glues
Andrä Brunner, Krzysztof Wierbiłowicz, Diandra Daumiller, Daniel Bexell et al.
The engineering of induced proximity has transformed drug discovery, yet the development of molecular glues remains largely serendipitous and restricted to the retrospective optimisation of accidental discoveries. Here, we present EvoBind-multimer, a deep learning framework for the de novo design of molecular glues directly from protein sequences. Unlike structure-based docking…
📖 Free full textPeer-ReviewedOpenAlexInternational Journal of Stroke · 2026
The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable
Meret Branscheidt, Wala Mahmoud, Christoph Bauer, Juan Camillo Cortes Ramirez et al.
OBJECTIVE: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological plausibility and clinical rationale for HDHI are well established. The fourth Stroke Recovery and Re…
📖 Free full textPeer-ReviewedOpenAlexGlobal Journal of Medical Pharmaceutical and Biomedical Update · 2026
Tele-Optometry and Mobile Eye Care Units: A Rural Vision Care Model for India
Rajib Mandal, Shamit Pal, Susmita Saha, Om Shankar Kamat et al.
India accounts for about 20% of the world’s visually impaired population. Rural and underserved populations are disproportionately affected by avoidable causes of blindness such as uncorrected refractive errors, cataracts, diabetic retinopathy, and glaucoma. Traditional facility-based eye care systems have often remained ineffective in reaching these communities due to geograph…
📖 Free full textPeer-ReviewedOpenAlexJournal of Intelligent Decision Making and Information Science · 2026
Next-Generation Artificial Intelligence for Cardiovascular Disease Prediction: A Systematic Review of Emerging Paradigms
Nilima Kulkarnir Anuja Gaikwad
Cardiovascular disease is a main cause of mortality worldwide that need the development of reliable and data-driven prediction models for timely diagnosis and intervention. Conventional risk assessment methods depend on statistical scoring and handcrafted clinical features fail to capture complex nonlinear features in several cardiovascular existing data. This systematic litera…
📖 Free full textPeer-ReviewedOpenAlexMagnetic Resonance Materials in Physics Biology and Medicine · 2026
Reproducibility of T2 relaxation time mapping in a phantom and human knee articular cartilage
Henri Leskinen, Nea Pulkkinen, Antti Paajanen, Amir Esrafilian et al.
Abstract Objective To quantify the reproducibility of knee articular cartilage T2 across a wide range of MR systems. Materials and methods The reproducibility of T2 relaxation time mapping was assessed by measuring the knee of a volunteer (n 1.5 T = 22, n 3T = 13) and a System Standard 130 phantom (n 1.5 T = 19, n 3T = 12) in 38 different clinical MRI scanners at 16 imaging sit…
📖 Free full textPeer-ReviewedOpenAlexIPS Journal of Public Health · 2026
Knowledge, Attitudes, and Practices Regarding Brucellosis among the General Population in Hafar Al-Batin, Saudi Arabia: An Analytical Cross-Sectional Study
Hossam Mohammed Yousef, Nasser Truki Aldhaferi, Tami Heleil Aldhaferi, Alsadig Alsayed Modawi et al.
Background: Brucellosis remains an endemic zoonosis in Saudi Arabia, where livestock husbandry, direct animal contact, and consumption of unpasteurized dairy products sustain preventable human exposure. Community knowledge, attitudes, and practices are central to risk reduction, yet locally generated evidence from Hafar Al-Batin is limited. Objective: To assess knowledge, attit…
📖 Free full textPeer-ReviewedOpenAlexPLOS Digital Health · 2026
Distinguishing common respiratory pathogens using machine learning of symptom profiles to prioritize diagnostic testing
Chunyan Xiang, Tingting You, Fei Zhou, Dong Liu et al.
Clinical symptoms are critical for diagnosing and managing upper respiratory tract infections, yet systematic comparisons across common pathogens remain limited. We aimed to characterize symptom signatures across common respiratory pathogens and to develop approaches that support the prioritization of diagnostic testing across pathogens. Using a large-scale, home-based multiple…
📖 Free full textPeer-ReviewedOpenAlexmedRxiv · 2026
A Human-in-the-Loop Large Language Model System Based on the Model Context Protocol for Differential Diagnosis from Electronic Medical Records and Literature
Hyunseok Lim, Hahn Yi, Jun Young Yoon, Heeyeon Kwon et al.
Diagnostic errors, including misdiagnoses and delayed clinical diagnoses, could affect outcomes of a significant patient population, particularly individuals presenting with rare diseases or non-specific symptoms. From rule-based diagnostic decision supporting systems (DDSS) to large language model (LLM) based tools for clinical reasoning have been developed to address these li…
📖 Free full textPeer-ReviewedOpenAlexJournal of Occupational Rehabilitation · 2026
Cost-Effectiveness of IMPRovE: A Multicomponent Intervention to Increase Adherence to Guideline Recommendations for the Diagnosis and Management of Work-Related Mental Health Conditions in General Practice
D. Mortimer, V. Camões-Costa, K. Nolidin, S. Chakraborty et al.
PURPOSE: To evaluate the cost and cost-effectiveness of a multicomponent intervention to increase general practitioners' (GPs) adherence to guideline recommendations for diagnosis and management of work-related mental health conditions (the Guideline). METHODS: Economic evaluation from Australian health system and societal perspectives based on data from a pragmatic hybrid III …
📖 Free full textPeer-ReviewedOpenAlexScientific Reports · 2026
Interpretable rehabilitation-oriented motion anomaly detection using wearable sensor data
Kumar Dorthi, Kiran Kumar Mamidi, Ravi Kanth Kotha, Neelima Bayyapu
Abstract Accurate detection of motion anomalies during physical rehabilitation is important for patient safety and recovery monitoring. Traditional assessment methods rely on visual observation. This often leads to subjective and inconsistent evaluations. To address this limitation, we propose a Support Vector-Guided Decomposition (SVGD) framework for semi-supervised rehabilita…
📖 Free full textPeer-ReviewedOpenAlexJournal of Acute Care Pharmacotherapy · 2026
Remdesivir versus usual care in the treatment of patients with COVID-19
Ivette M. Solís-Nolasco, Ian Murphy, Michael McAlister, Cara Slaton
Background Remdesivir was approved by the Food and Drug Administration in 2020 for treating hospitalized COVID-19 patients and those at high risk of severe disease. Although studies have shown a reduced risk of severe outcomes during the Omicron era compared to earlier variants, data on the effectiveness of remdesivir during this period remains limited. Objective To evaluate th…
📖 Free full textPeer-ReviewedOpenAlexContemporary Clinical Trials · 2026
Effectiveness of psychologically informed physical therapy, tendon-specific exercise program and routine physical therapy in prolonged unilateral shoulder pain and symptom correlations with imaging: a single-center, randomized, parallel-group, three-arm study (RESPECT)
Antti Kemppainen, Juhani Määttä, Eveliina Heikkala, Mikko Lausmaa et al.
BACKGROUND: Shoulder complaints are one of the most common musculoskeletal ailments. Patient-specific characteristics such as obesity, depression and physical labor are established risk factors, whereas imaging findings are common and associations between specific imaging findings and symptomatology is limited. General exercises are considered useful in treatment whereas eviden…
📖 Free full textPeer-ReviewedPubMedPhysics in medicine and biology · 2026
S2V-DREME: a time-resolved slice-to-volume MR image reconstruction framework with dynamic reconstruction and motion estimation.
Qian X, Shao HC, Deng J, Dai Y et al.
Existing volumetric MRI techniques are constrained by the trade-off between acquisition time and image quality, limiting accuracy in motion-impacted sites such as the liver. To enable fast, high-quality volumetric imaging with sufficient spatiotemporal resolution, we developed a time-resolved volumetric MRI technique that recovers 3D volumes from two orthogonally acquired MR sl…
📖 Free full textPeer-ReviewedOpenAlexThe European Journal of Health Economics · 2026
The application of excess hazard models for plausible long-term extrapolation in cost-effectiveness: a re-evaluation of immunotherapy in advanced non-small cell lung cancer using the KEYNOTE-024 trial
Kun Kim, Michael Sweeting, Nils Wilking, Linus Jönsson
Abstract Background Economic evaluations often rely on immature data to evaluate cost-effectiveness of new treatments. Pembrolizumab was approved for advanced non-small cell lung cancer with high PD-L1 expression based on interim data from the KEYNOTE-024 trial. Using 5-year follow-up data, we re-evaluated the cost-effectiveness analysis to assess optimal survival models and th…
📖 Free full textPeer-ReviewedOpenAlexmedRxiv · 2026
TabMedQA: From Structured Data to Question-Answer Datasets in Early Clinical Decision-Making
Gabriel Iturra-Bocaz, Petra Galuščáková, Sol Vedde, Álvaro Fernández-Quilez
The rising adoption of Large Language Models (LLMs) and Retrieval Augmented Generation (RAG) in clinical general practice demands datasets that capture realistic early-stage clinical decision-making, where experts must decide on follow-up actions based on sparse, structured patient data. Existing medical Question-Answering (QA) resources primarily address post-diagnostic or spe…
📖 Free full textPeer-ReviewedOpenAlexDaehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · 2026
Therapeutic effects of Nigella sativa (black seed) via antioxidant and anti-inflammatory activity in the testes of adult male mice subjected to transient scrotal hyperthermia
Ermia Tavakoli, Zahra Arazm, Azar Afshar, Fakhroddin Aghajanpour et al.
Objective: In mammals, a lower testicular temperature is required for normal spermatogenesis. Testicular temperature can increase due to multiple factors, including lifestyle-related exposures, ultimately leading to damage to germ cells and impaired sperm parameters. Nigella sativa (black seed) has been reported to improve sperm parameters and exhibits a wide range of therapeut…
📖 Free full textPeer-ReviewedOpenAlexVCU Scholars Compass (Virginia Commonwealth University) · 2026
Commissioning & Daily QA of Converted LINAC for Electron FLASH
Tomaj Javidtash
Ultra-high dose rate (FLASH) radiotherapy has demonstrated promising normal tissue sparing in preclinical studies; however, the lack of standardized dosimetry, commissioning, and quality assurance (QA) methodologies remains a major barrier to its reproducible and safe implementation. In particular, conventional clinical commissioning and QA protocols are not directly applicable…
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Pharmacology · 2026
Optimizing PD-1/PD-L1 inhibitors plus chemotherapy for driver mutation–negative non-squamous NSCLC in China: a cost-effectiveness analysis
Jianwei Ji, Qian Du, Mengmeng Teng, Fuhong Qin et al.
Background PD-1/PD-L1 inhibitors combined with chemotherapy have improved survival outcomes in patients with driver mutation–negative non-squamous non-small cell lung cancer (non-sqNSCLC). However, the comparative efficacy, safety, and economic value of available PD-1/PD-L1 inhibitor–based regimens remain uncertain in China. Methods We conducted a network meta-analysis to indir…
📖 Free full textPeer-ReviewedOpenAlexSocial Science & Medicine · 2026
Normative values for paid and unpaid work productivity for estimating productivity-adjusted life expectancy in Finland
Piia Lavikainen, Jari Heiskanen, Zanfina Ademi, Yeji Baek et al.
Background Normative regional estimates of productivity are essential for deriving reliable predictions of productivity-adjusted life expectancy (PALE). This study aimed to establish Finnish population norms for health-related productivity by estimating age- and sex-specific norms for paid and unpaid work productivity indices, as well as combined weighted productivity index. Us…
📖 Free full textPeer-ReviewedOpenAlexPhysics in Medicine and Biology · 2026
Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis
S Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons et al.
OBJECTIVE: Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone.…
📖 Free full textPeer-ReviewedOpenAlexScientific Data · 2026
A longitudinal data resource to study brain development and transdiagnostic variation in executive function
Brooke L. Sevchik, Golia Shafiei, Kristin Murtha, Sophia Linguiti et al.
Abstract Executive function (EF) develops rapidly during adolescence. However, deficits in EF also emerge in adolescence, representing a transdiagnostic symptom associated with many forms of psychopathology. To promote transdiagnostic research on EF during development, we introduce a new data resource – the Penn Longitudinal Executive functioning in Adolescent Development study…
📖 Free full textPeer-ReviewedOpenAlexDiscover Health Systems · 2026
Variation in Health Technology Assessment recommendations and reimbursement of Advanced Therapy Medicinal Products across nine european countries
Paraskevi M. Georgiou, Kostas P. Athanasakis
Advanced Treatment Medicinal Products (ATMPs) are innovative treatments aimed at severe diseases. However, patient access varies across European countries. The present research reviews the reimbursement status of the licensed ATMPs in England, Scotland, France, Germany, Italy, Spain, Ireland, Denmark and Sweden and aims to assess the differences in the outcomes of the decisions…
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Public Health · 2026
A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities
Sergio Camilo Cabrera-Salcedo, Luis Gabriel Parra‐Lara, Mónica Fernandes-Pineda, Alejandro Toro-Pedroza et al.
Chimeric antigen receptor (CAR) T-cell therapy is a transformative modality for refractory hematologic malignancies; however, its adoption in Latin America and the Caribbean (LAC) is severely constrained by prohibitive manufacturing costs, limited specialized infrastructure, and fragmented regulatory frameworks. To address this translational gap, we propose a pragmatic, cost-ad…
📖 Free full textPeer-ReviewedOpenAlexArabian Journal of Chemistry · 2026
Recent developments in transition metals supported on functionalized materials for enhancing Suzuki reactions
Zhanao Lv, Yahao Dong, Tao Li, Jiajun Bi
The construction of aryl˗aryl, aryl˗heteroaryl or heteroaryl˗heteroaryl linkages via Suzuki coupling reactions is essential and common in industrial applications, which warrants the development of the pharmaceutical drugs, dyes, and agrochemicals fields. In this review, the general mechanism and practical application of Suzuki reactions are briefly described. Importantly, speci…
📖 Free full textPeer-ReviewedOpenAlexFrontiers in Cardiovascular Medicine · 2026
A CCTA coronary plaque radiomic model for predicting major adverse cardiovascular events in patients with coronary artery disease
Yue Zhang, Hongkun Zhang, Minglang Yang, Jingyi Wang et al.
Introduction Coronary artery disease (CAD) remains the leading cause of cardiovascular mortality worldwide, and early accurate risk stratification for major adverse cardiovascular events (MACE) is critical for improving clinical outcomes. Coronary computed tomography angiography (CCTA) is the cornerstone of non-invasive plaque assessment, yet conventional morphological evaluati…
📖 Free full textPeer-ReviewedOpenAlexInternational Journal of Clinical Oncology · 2026
Recommendations for generating real-world evidence with regulatory-grade relevance and reliability
Yasutoshi Sakamoto, Hideaki Bando, Yoshihiro Aoyagi, Hiroki Sokuoka et al.
Real-world data (RWD) and real-world evidence (RWE) are increasingly incorporated into regulatory decision-making to complement randomized controlled trials (RCTs), particularly in settings where conventional trial designs are infeasible, such as rare diseases, rare molecular subtypes, and post-marketing evaluation. Across regulatory authorities, the use of RWD/RWE is consisten…