Radiotherapy QA · Literature Radar
Adaptive RT workflows — Ethos / Halcyon, plan-of-the-day, CBCT-driven online replanning. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Archibald-Heeren BR, Leong A, Middlebrook N, Phung P et al.
BackgroundOffline adaptive radiotherapy (OffART) offers potential dosimetric and clinical advantages by adjusting planned dosimetry in response to systematic patient changes throughout treatment, howe…
Flühmann T, Guyer G, Vallet V, Svensson S et al.
BackgroundModern radiotherapy techniques do not automatically account for anatomical changes during treatment, which can lead to reduced target coverage, hotspots, or increased dose to healthy tissues…
Xiao F, Delopoulos N, Wahl N, Volz L et al.
PurposeAccurate dose calculation is a fundamental component of modern radiotherapy, enabling precise tumor irradiation while sparing surrounding healthy tissue. With the increasing adoption of magneti…
Sarkar B.
ObjectivesThis systematic narrative review evaluates the efficacy, safety, and future potential of stereotactic body radiation therapy (SBRT) in locally advanced pancreatic cancer (LAPC), particularly…
Leblanc J, Terlizzi M, Lapierre A, Le Guévelou J.
Adaptive radiotherapy has emerged as a promising strategy to improve the precision of prostate cancer treatment by accounting for daily anatomical variations. Recent technological advances have enable…
Kassardjian AA, Maraghechi B, Shi C, Ai H et al.
Purpose/objectivesOptimal implementation of gadoxetate disodium injection (GDI) in liver-directed MR-guided online adaptive radiotherapy (MRgART) remains poorly characterized. Herein, we evaluated the…
Birring E, Zhao Y, Lim TY, Mohammedsaid M et al.
PurposeMagnetic resonance (MR) -guided online adaptive radiotherapy requires skill in online adaptive treatment planning. The aim of this study was to demonstrate that radiation therapists, with appro…
Gao Y, Hsu E, Pham D, Skinner L et al.
PurposeConventional liver stereotactic ablative radiotherapy (SABR) typically requires a CT simulation visit followed by multiple treatment fractions, which can increase patient burden and limit acces…
Poeta S, Gulyban A, Paquier Z, Michel M et al.
PurposeTo quantify inter-physician contouring variability and evaluate its dosimetric impact in pancreatic ductal adenocarcinoma (PDAC) patients treated with daily online adaptive MR-guided stereotact…
Ben Rejeb M, Lahiouel S, Hamdoun A, Abdessatar G et al.
IntroductionInterfractional anatomical variations during pelvic radiotherapy for locally advanced cervical cancer may compromise target coverage and increase organ-at-risk (OAR) irradiation. This stud…
Ursi G, Lekić M, Kaučić H, Kovačević A et al.
Ultrahypofractionated whole-breast radiotherapy reduces treatment burden but increases the importance of accurate dose delivery at each fraction. This retrospective single-center study evaluated cone-…
Kenny K, Snyder KC, Huang Y, Vu K.
Ethos Intelligent Optimization Engine version 2 (IOE v2) generates automated treatment plans using user-defined templates that may not fully account for patient-specific anatomy. This retrospective st…
Penney J, Chytyk-Praznik K.
Background:When cervical cancer patients are treated with external beam radiation therapy, patient-specific anatomical changes, particularly bladder filling, alter the position and shape of the target…
Rodriguez-Gonzalez B, Escobar-Corominas I, Rodriguez-Vila B, Hernandez-Rubia J et al.
Daily anatomical changes during radiotherapy demand accurate imaging and segmentation to support adaptive treatment. We propose Simultaneous Evidential Network for Synthesis and SEgmentation (SENSSE),…
Williams B, Sandoughdaran S, Chick J, Dunlop A et al.
IntroductionBladder MRI-guided online adaptive radiotherapy (MRIgART) has enabled a reduction in planning target volume (PTV) margins, reducing normal tissue irradiation. Yet, further margin reduction…
Langner D, Gani C, Boeke S, Niyazi M et al.
PurposeDespite remarkable auto-segmentation performance and growing clinical adoption, models frequently fail to generalize beyond the training distribution. Therefore, this study aimed to develop and…
Janiszewska M, Raczkowski M.
Background/objectivesOnline adaptive radiotherapy (oART) re-optimizes treatment on the anatomy of the day, but automatically generated plans require dosimetric verification and dose-volume assessment.…
Lindegaard AM, Håkansson K, Appelt A, Bernsdorf M et al.
IntroductionOnline adaptive radiotherapy (oART) may improve head and neck cancer (HNC) treatment, where anatomical changes during radiotherapy (RT) are common. However, oART is resource-intensive and …
Zheng Y, Lei R, Qu A, Li M et al.
Online adaptive radiation therapy (ART) lengthens the session, but many published times report one interval and do not isolate ART-specific activity. We developed a console timer that records wall-clo…
Kretzschmar L, Wallimann P, Obergfell LM, Tanadini-Lang S et al.
Serial MRI during radiotherapy may enable early response assessment and guide adaptive treatment strategies; however, data on intratreatment volumetric changes remain limited. We herein report results…
Lohela J, Rytky SJO, Karhula SS, Nikkinen J.
PurposeThe study evaluated the image quality of the cone beam computed tomography (CBCT) system on Varian TrueBeam linear accelerators with HyperSight (TB-HS) and compared it with the standard TrueBea…
Wang S, Wang X.
Cone-beam computed tomography (CBCT)-based adaptive radiotherapy (ART) has emerged as a promising strategy for addressing inter-fractional anatomical and physiological changes during treatment. By inc…
Zhang Z, Hobbis D, Jiang J, Rangnekar A et al.
Online adaptive radiotherapy (ART) requires fast and accurate delineation of targets and organs at risk on cone-beam computed tomography (CBCT). Although deep learning (DL)-based CBCT auto-segmentatio…
Crowe SB, Kairn T.
BackgroundReal-time multileaf collimator (MLC) adaptation is available on some helical tomotherapy treatment units. However, these systems are not supplied with software that facilitates the retrospec…
Wang Z, Wang S, Liu N, Guan Q et al.
BackgroundOnline adaptive radiotherapy (ART) employs modalities like CBCT, CT, and MRI. For abdominal malignancies, MRI stands out with superior soft-tissue contrast, no ionizing radiation, and functi…
Gevorkyan GS, Zhu L, Tegtmeier RC, Santos Toesca D et al.
BackgroundDose-guided adaptive fractionation (DGAF) was proposed as a simpler alternative of adaptive radiation therapy, using organ variation simulation for proof of concept. However, its dosimetric …
Hartfelt PB, Bisgaard ALH, Ejlsmark MW, Bahij R et al.
PurposeThis prospective single-center cohort study evaluated outcomes and toxicity after ablative stereotactic magnetic resonance imaging (MRI)-guided adaptive radiation therapy (SMART) in patients wi…
Hecking J, Malygina H, Palm J, Salazar Zuniga B et al.
PurposeOnline adaptive radiotherapy (oART) minimizes inter-fractional variation, yet intra-fractional motion (IFM) remains a source of uncertainty. We quantified intra-adaptational motion (IAM) using …
Jassim HH, Banaee N, Nedaei HA, Imae T.
This study evaluated the performance of three categories of deformable image registration (DIR), namely intensity-based, spline-based, and hybrid methods, for planning CT (pCT)-to-cone-beam CT (CBCT) …
Wu L, Ma S, Zhang X, Song Z et al.
IntroductionConsolidation immunotherapy postchemoradiotherapy is standard for unresectable stage III non-small-cell lung cancer (NSCLC) per PACIFIC and GEMSTONE-301, but optimal integration with chemo…
Barten DLJ, Goudschaal K, Hinnen KA, de Jong R et al.
PurposeManaging inter- and intrafraction motion remains a major challenge in cervical cancer radiotherapy. This study reports a two-year, single-centre experience with daily CBCT-guided cervical onlin…
Chen X, Pang Y, Lian J, Yap PT.
Accurate CBCT-to-CT translation is important for image-guided and adaptive radiotherapy in prostate cancer, where treatment-day anatomy can differ substantially from planning CT. Most unsupervised met…
Kalinauskaite G, Künzel LA, Rubarth K, Dannehl J et al.
PurposeThis study aimed to prospectively compare clinician-reported acute toxicity and patient-reported health-related quality of life (HRQoL) between daily cone-beam CT (CBCT)-based online adaptive r…
Dzierma Y, Etemad Zadeh S, Tschernig T, Palm J et al.
PurposeThe aim of this study is to dosimetrically validate deformable dose accumulation in online adaptive radiotherapy using realistic physiological tissue deformation and comparing point dose measur…
Xiao M, Wang Q, Yu G, Li F et al.
BackgroundGiant ulcerative breast cancers (>2,000 cc) with active hemorrhage present a critical therapeutic challenge, as conventional radiotherapy carries a high risk of severe toxicity to surroundin…
Moncrief OG, Warren EG, Larramendi LZ, Wang CJ et al.
Daily anatomical variations can compromise dosimetric plan quality in kidney stereotactic ablative radiotherapy (SABR). The purpose of this study is twofold: (1) To characterize the impact of daily an…
Wang X, Lim TY, Wang H, Dabaja BS et al.
A patient presenting with stage I follicular lymphoma was dispositioned for a definitive and curative radiation treatment. The tumor had significant daily movement, as much as 3.83, 3.26 and 12.42 cm …
Vicedo González MA, García Hernández MT, Alcaraz Lozano ML, Pardos RG et al.
Adaptive Radiotherapy (ART) updates treatment plans based on newly acquired anatomical information to maintain dosimetric accuracy. Image-Guided Radiotherapy (IGRT) is essential for detecting anatomic…
Zidan A, Chai GW, Chen D, El-Sherbini A et al.
Background/objectivesPersonalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR) delivers high-dose stereotactic radiation as temporally separated pulses, permitting interval response a…
Takahashi Y, Takahashi N, Kageyama S, Tanaka S et al.
BackgroundHydrogel spacers are widely used in radiotherapy for localized prostate cancer to reduce the rectal dose. While generally safe, acute anatomical changes in the prostate gland itself, specifi…
Lim S, Park KR, Lee DH, Choi JH et al.
To evaluate the dosimetric impact of anatomical changes during whole-breast irradiation (WBI) and to assess the utility of offline adaptive radiation therapy (ART) in patients treated with the field-i…
Tan D, Edwards L, Byrne HL, Liang T et al.
We present a case series of four patients with five splenic metastases treated with stereotactic body radiation therapy (SBRT) using a 1.5-T Unity (Elekta AB, Stockholm, Sweden) magnetic resonance lin…
Dotel R, Bayat F, Hu J, Pyakurel U et al.
Background and purposeDeep learning-based segmentation of organs and tumors in cone-beam computed tomography (CBCT) is critical for improving workflow efficiency and accuracy in dose delivery monitori…
Cooper S, Brennan VS, Alongi F, Chick J et al.
BackgroundLocal recurrence in prostate cancer (PCa) after radical radiotherapy has become increasingly prevalent in the era of next-generation imaging. Meta-analyses suggest a favourable adverse event…
Sánchez-Artuñedo D, Campos-Domenech A, Reyes-López V, Matheos-Perez J et al.
PurposeSafety and quality assurance software in external beam radiotherapy may improve oncologic outcomes by enabling early detection of treatment delivery deviations. This work describes the clinical…
Fauci F, Reggiori G, Lobefalo F, Paganini L et al.
BackgroundRe-irradiation is increasingly applied in prostate cancer management, supported by improved techniques and radiobiological modeling. Accurate cumulative dose estimation is crucial for predic…
Liu W, Zhang H, Mazur T, Schiff JP et al.
Proton stereotactic body radiotherapy (SBRT) offers advantageous dosimetric properties but is highly sensitive to setup variation, anatomic change, and range uncertainty, limiting broader clinical ado…
Dudas D, Blöcker TJ, Palacios MA, Wei C et al.
Background and purposeThis study presents a novel workflow for automated gross tumor volume (GTV) adaptation in online adaptive magnetic resonance imaging (MRI)-guided radiotherapy using promptable se…
Sekkat H, Khallouqi A, Hammougua O, Halimi A et al.
Xiao C, Lin W, Tian F, Zhang J et al.
Accurate deformable registration between planning CT (computed tomography) and cone-beam CT (CBCT) is essential for adaptive radiotherapy in nasopharyngeal carcinoma, but cross-modality intensity diff…
Shabbir R, Zakacz A, Sivakaran R, Osorio EV et al.
BackgroundDaily adaptive magnetic resonance (MR)-guided treatment changes delivered dose distributions, making cumulative dose uncertain. This work assessed the feasibility of exploring potential rela…
He S, Yu H, Yang Y, Mao Q et al.
BackgroundCurrently, there is no clear guidance on the appropriate population or timing for adaptive radiotherapy (ART) in high-grade glioma (HGG) patients. This study aims to provide individualized A…
Moodaley P, Lim K, Do V, Descallar J.
IntroductionOffline adaptive replanning is an appealing strategy in cervical cancer external beam radiotherapy (EBRT) to account for tumour shrinkage. It remains unclear whether volume reduction with …
Li C, Rusu D, Sultan R, Bagher-Ebadian H et al.
BackgroundManual organ-at-risk (OAR) delineation takes 20-40 min per case, a major bottleneck within the 50-90 min treatment window of abdominal MR-guided adaptive radiotherapy (MRgRT). Most deep lear…
Ocanto A, Teja M, Gonsalves D, Vásquez W et al.
Magnetic resonance-guided radiotherapy (MRgRT) delivered with MR-linac technology represents a major advance in lung cancer radiotherapy, enabling daily online adaptive planning based on high-quality …
Cui S, Chan MF, Zheng D.
Online adaptive radiotherapy (OART) modifies treatment plans using anatomy-of-the-day imaging, but successful clinical implementation depends on automated planning strategies that can generate high-qu…
Clarke NL, Hughes JL, Wanigaratne D, Yeo AU.
BackgroundCone-beam computed tomography (CBCT) is integral to image-guided radiation therapy and increasingly used for adaptive radiotherapy and CBCT-based dose calculation. Conventional kV-CBCT syste…
Yu P, Pu Y, Xiong T, Hu D et al.
PurposeRecent studies indicate that lung function can change significantly during radiation therapy (RT) course. However, additional function imaging scans are not part of routine RT workflow, limitin…
Li Z, Chen L, Gan G, Guo J et al.
BackgroundGenerating high-quality CT images from cone-beam computed tomography (CBCT) is critical for clinical applications such as online adaptive radiotherapy (ART). Although deep learning methods, …
Park B, Kim T, Lee KW.
BackgroundCone-beam computed tomography (CBCT) is increasingly used in adaptive radiotherapy (ART), yet the dosimetric accuracy and image quality of advanced CBCT imaging platforms-such as Halcyon Hyp…
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