Adaptive RT workflows — Ethos / Halcyon, plan-of-the-day, CBCT-driven online replanning. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Felipe M. Berg, Eric Abenojar, Pinunta Nittayacharn, Nathan K. Hoggard et al.
The localization of prostate cancer by ultrasound remains limited by the lack of B-mode conspicuity and the confinement of clinically approved microbubbles (MBs) to the vasculature. This precludes differentiating viable tumor, necrotic tissue, and margin-associated disease. We investigated prostate-specific membrane antigen (PSMA)-targeted lipid-shelled perfluorocarbon nanobubb…
In the diagnostic realm, ML improves the accuracy of differential diagnosis for complex head and neck lesions. Qin et al. performed a systematic review and meta-analysis of 17 studies involving 3,321 participants for identifying sinonasal inverted papilloma, demonstrating that radiomicsclinical fusion achieves superior diagnostic performance (sensitivity 0.85, specificity 0.87)…
Lidia Borghi, Maria Adelaide Morabito, Elaine C. Meyer, Philip Scilio et al.
Introduction Empathy has been recognized as a crucial quality for patient-centered care and is associated with improved therapeutic outcomes and greater satisfaction of patients and clinicians. However, empathy may decline over the course of clinical practice, highlighting the need for effective educational interventions. Methods The study examined changes in empathic attitude …
Marc Vincent Barcelona, Noelia Sanmamed, Enrique Gutierrez Valencia, Alejandro Berlín et al.
We report early toxicity outcomes after institutional implementation of prostate SBRT using 42.7 Gy in seven fractions delivered with either MR-guided adaptive SBRT (MRgSBRT) or CT-guided non-adaptive SBRT (CTgSBRT). Between July 2019 and May 2023, 216 patients received this regimen. Genitourinary (GU) and gastrointestinal (GI) toxicities were retrospectively assessed using the…
The first day of the conference chaired by Iannis Adamopoulos and Hiroshi Takayanagi highlighted how rapidly the field of osteoimmunology is expanding beyond classical bone resorption and formation, toward a more integrated view of bone as a dynamic immune, vascular, metabolic and stem cell organ.Across Sessions I and II, speakers explored how specialized niches in bone marrow,…
Background: Gynecological cancer patients frequently experience anxiety, depression, and social isolation, particularly regarding body image, sexual health, fertility, and family roles. Radiotherapy is a central treatment modality and provides a clinically important window for psycho-oncological support. Objective: To synthesize evidence on psychological health challenges and s…
Yingjian Wang, Zhe Wang, Fangdi Zhou, Yu Qiao et al.
Gastrointestinal cancers frequently develop immune exclusion and therapeutic resistance, yet these phenotypes are often described separately. Cancer-associated fibroblasts (CAFs) are key stromal architects of immune-excluded tumor microenvironments, and their heterogeneous states can evolve under chemotherapy, radiotherapy, immunotherapy, targeted therapy, and anti-angiogenic p…
Generative AI chatbots are increasingly used to obtain health information. In glioma, patient-facing chatbot text should be safe, accurate, reliable, empathetic, transparent, and readable. However, readability formulas quantify textual complexity and do not establish patient comprehension or educational effectiveness. This study therefore evaluated clinician-rated, patient-faci…
Katsuyuki Shirai, Noriko Kishi, Hideaki Hirashima, Masashi Endo et al.
Background: Online adaptive radiotherapy (oART) can change the dose distribution briefly to match the shape of the targets and organs at risk. Cone-beam computed tomography (CBCT)-guided oART has been introduced in clinical practice and is expected to improve clinical outcomes. This technology allows treatment as an extension of conventional CT-based image-guided radiotherapy t…
Dominic Kaddu-Mulindwa, Xianqing Mao, Caroline Duhem, Sigrid De Wilde et al.
Introduction Artificial intelligence (AI) is rapidly entering the field of medical oncology. Clinician literacy, ethical awareness, and governance structures are prerequisites for safe implementation, yet real-world data on adoption, training and ethical perceptions from small European healthcare systems remain scarce. Methods We conducted an anonymous national cross-sectional …
ObjectiveTo propose a deep multimodal synergistic survival analysis framework (Deep Multimodal Synergistic Survival Network, DMSSN) to achieve accurate prognostic analysis for clear cell renal cell carcinoma (ccRCC).MethodsThis study (DMSSN) utilized matched multimodal data from the TCGA-KIRC database, including CT imaging data, whole slide images (WSI), copy number variation (…
BackgroundElectroencephalogram (EEG) interpretation is essential for neurological diagnosis, but expert interpretation is limited globally, and existing AI methods address narrow tasks. This study aimed to develop and externally validate a broadly applicable foundation model capable of expert-level performance across diverse EEG tasks and clinical settings.MethodsIn this multic…
Objective To evaluate the dosimetric and delivery-time effects of Jaw width, Pitch, and modulation factor (MF) in Radixact TomoHelical planning across different anatomical scenarios, and to develop anatomy-stratified practical guidance for parameter selection. Methods Eighty cases were stratified into four anatomical groups according to target length, geometric complexity, and …
Nishitani M, Okamoto H, Chang W, Kuwahara J et al.
Current quality assurance phantoms often lack MR signal, deformability, or real-time dosimetry capability, limiting comprehensive end-to-end evaluation for MR-guided online adaptive radiotherapy (MRgOART), including verification of deformable image registration (DIR) accuracy and the adaptive workflow within a single phantom. This study aimed to develop a CT/MRI-compatible anth…
Fatih Ekinci, Nur KAYA, Zeyneb Sude ALACA, Berfin TÜRKOĞLU et al.
Accurate prediction of ion-induced energy deposition in polymeric materials is essential for space radiation shielding and advanced radiotherapy applications. This study proposes a generalizable machine learning framework for predicting Bragg peak characteristics using Monte Carlo simulation. Energy deposition profiles were generated via SRIM/TRIM and Geant4 for ions with atomi…
Jinmin Shi, Shaimaa Abdel-Ghany, Mariam Abdel-Fattah, Xuebo Hu et al.
Adipose tissue, once considered a passive fuel store, is now recognized as a dynamic endocrine organ that shapes cancer behavior. Within the tumor microenvironment (TME), cancer-associated adipocytes (CAAs) undergo marked reprogramming-losing large lipid droplets, adopting fibroblast-like features, and intensifying lipolysis-while releasing proinflammatory mediators that accele…
Glutamine, the most abundant amino acid in human serum, serves not only as a key nutrient for maintaining normal cellular biological functions but also as an essential metabolic substrate for the proliferation and survival of tumor cells. Tumor cells exhibit a pronounced characteristic of “glutamine addiction” through metabolic reprogramming. This trait endows tumor cells with …
Angel Yordanov, Eva Tsoneva, Polina Damqnova Dimitrova, Stoyan Kostov et al.
Objective To determine whether unsupervised integration of routinely accessible immunohistochemical immune features can identify clinically relevant tumor immune microenvironment phenotypes in cervical cancer. Methods We performed a retrospective exploratory analysis of surgically treated cervical cancer cases with complete scoring for a 20-feature immunohistochemical immune pa…
BuLang Tang, Yihe Kuai, Zhitao Ye, Xuan Zhao et al.
Clonal hematopoiesis (CH) arises when age-associated somatic mutations confer a proliferative advantage on hematopoietic stem and progenitor cells, producing expanded clonal blood cell populations. Clonal hematopoiesis of indeterminate potential (CHIP) is clinically defined by a variant allele fraction (VAF) of ≥ 2% in individuals without hematologic malignancy or otherwise une…
Amin Zadeh-Shirazi, Bryan W. Day, Hui K. Gan, Guillermo A. Gomez
Effective glioblastoma care requires integrating multiparametric longitudinal MRI with histopathology, molecular profiling, and clinical records documenting surgery, radiotherapy, chemotherapy, and supportive treatments. In routine practice, however, these data streams are often evaluated separately rather than jointly, which can delay molecularly informed stratification, limit…
Proton beam therapy (PBT) is an advanced form of radiation therapy that offers distinct physical and dosimetric advantages over conventional photon-based radiotherapy. The characteristic Bragg peak enables protons to deposit most of their energy at a defined depth within the tumor while minimizing the radiation dose delivered to surrounding healthy tissues. This review discusse…
Adyb-Adrian Khal, Lucas Lo Cunsolo, Virginie Rampal - Rocher, Jean-Luc Jouve et al.
PURPOSE: Paediatric limb-salvage surgery after tumour resection is challenging because reconstruction must account for small skeletal dimensions, immature bone, and residual growth. This study aimed to evaluate the long-term clinical, radiological, functional, and oncological outcomes of vascularized fibular epiphyseal transfer (VFET) after paediatric oncological resection. MET…
Maria Garcia Requesens, Arun K. Mankan, Luca Cantini, Marco Calabresi et al.
Health Digital Twins (HDTs) have attracted increasing interest as a potential tool for improving both patient care and clinical research, particularly in oncology where clinical trials remain slow, costly, and operationally complex. This primer introduces the concept of digital twins in a form accessible to professionals involved in oncology clinical research and outlines the m…
Canine soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal neoplasms with overlapping histological features, historically considered as a single entity. Distinct histotypes, however, exhibit different biological behaviors, underscoring the need for detailed characterization using histology, immunohistochemistry, and molecular approaches. This study aimed to inv…
Marc García-Trujillo, Jesús Lavado‐García, Pol Pérez‐Rubio, Francesc Gòdia et al.
Extracellular vesicles (EVs) and HIV-1 Gag virus-like particles (VLPs) represent promising platforms for therapeutic delivery and vaccine development. However, their molecular cargo may critically influence their biological properties and clinical applicability. In this study, a multi-omic approach combining transcriptomic and lipidomic analyses was applied to characterize and …
Yulan Kui, Fang Tong, Ruiguang Zhang, Jian Wang et al.
Abstract Radiotherapy is a mainstay treatment option for non-small cell lung cancer (NSCLC). However, radiation remodels the tumor immune microenvironment by adaptively upregulating the immunoregulatory checkpoint CD47, leading to phagocytic evasion and radioresistance. Although targeting CD47 shows promising antitumor effects, severe hemolytic toxicity caused by CD47 antibodie…
Adenosine is a central metabolic regulator of tumor immune escape, shaping the tumor microenvironment (TME) through suppression of effector lymphocytes and reprogramming of myeloid populations. Extracellular adenosine is generated primarily via the ectonucleotidases CD39 and CD73 and signals through A2A (A2AR) and A2B (A2BR) receptors on T cells, NK cells, tumor-associated macr…
Recently, conventional domain adaptation (DA) methods have demonstrated promising performance in cross-subject classification in electroencephalogram (EEG)-based brain-computer interfaces (BCIs). However, these methods require direct access to labeled source subject data, potentially compromising biometric privacy. Source-free domain adaptation (SFDA) addresses this issue by le…
Wendy Osborne, Hannah Bielby, Kate Cwynarski, Dima El‐Sharkawi et al.
Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematology (BSH) Good Practice Paper, there have been important advances in imaging, radiotherapy approaches …
Refugee populations experience major challenges in accessing cancer diagnosis and treatment, which frequently leads to delayed presentation and more advanced disease stages. However, there is still limited information on survival outcomes of refugee cancer patients receiving care in large metropolitan centers. This retrospective single-center cohort study included Syrian refuge…
Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively been abandoned. Indeed, cell death is not merely a passive endpoint but can actively shape immune resp…
Koichiro Kumano, Hiromitsu Nakahashi, Osamu Shimomura, Yoshimasa Akashi et al.
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) comprises heterogeneous classical and basal-like subtypes. Although pancreatic cancer organoids (PCOs) are widely used, normoxic cultures preferentially maintain the classical subtype, limiting their ability to represent intrinsic intratumoral heterogeneity. Because PDAC develops in profoundly hypoxic microenvironments, the in…
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality globally, with acquired chemoresistance posing a significant therapeutic challenge. Artemisinin (DHA), a semisynthetic derivative of artemisinin, has been reported to exhibit antitumor activity; however, its molecular mechanism in drug-resistant NSCLC remains unclear. This study systematica…
Linwei He, Anouk E. W. Teunissen, Nadine Bol, Kelly M. de Ligt et al.
PURPOSE: Patient-reported outcome measures (PROMs) are increasingly used in oncology to support patient-centered care, yet their implementation in routine practice remains inconsistent. Using a communication-centered perspective which conceptualizes PROMs implementation as a process of meaning exchange between patients, clinicians, and implementation staff, this study examined …
A. Handke, P. Paffenholz, K. Schlack, K. E. Seifert et al.
PURPOSE: Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyzed oncologic outcomes and therapeutic patterns in a multicenter German cohort. METHODS: Retrospective multice…
Lingling Pan, Jiayue Wu, Qianyun Jiang, Linyan Wang et al.
This qualitative meta-synthesis systematically reviewed studies on post-traumatic growth (PTG) in people with cancer. A comprehensive search of nine databases was conducted up to February 2025. Following PRISMA guidelines, the methodological quality of included studies was assessed using the JBI checklist, and data were analyzed via thematic synthesis. Fifteen studies, all rate…
Jenny Adamski, John Apps, Sarita Depani, Rebecca M. Hill et al.
Rare paediatric central nervous system (CNS) tumours comprise a biologically-heterogeneous group of low-incidence diseases that present significant challenges to both therapeutic development and clinical research, limiting the availability of high-quality evidence to guide clinical care. The UK3CR Children's Cancer Research Group (CRG) CNS Tumours Subgroup convened a multidisci…
Kelly Skelton, Sophie Jessop, Morgan Atkinson, Gabrielle Vigar et al.
Purpose As survival rates for childhood and young adult cancer continue to improve, there is a growing need for comprehensive survivorship care that addresses long-term health outcomes after radiation treatment. This review aimed to synthesize and critically appraise national and international survivorship guidelines.Methods Literature searches were performed across MEDLINE, Em…
Shiva Velayati, Masoumeh Zahmatkeshan, Naghmeh Farzaneh, Fariba Esmaeili et al.
The integration of diagnostic and therapy into a single nanoplatform has been proved to be a revolutionary approach for precision medicine, which allows the simultaneous disease detection, treatment, and therapeutic monitoring. Although great progress has been achieved in nanotheranostics, many traditional nanomaterials still suffer from low drug loading capacity (LC), ineffici…
Eslam E. Abd El-Fattah, G. Ngai, Rachael Mooney, Karen S. Aboody
PURPOSE OF REVIEW: Obesity is a potent risk factor for cancer, primarily driven by a state of chronic inflammation. A key mechanism linking adipose tissue dysfunction to tumorigenesis is the induction of cellular senescence and the related Senescence-Associated Secretory Phenotype (SASP), which is not clearly defined. RECENT FINDINGS: In obesity, expanding adipose tissue become…
Brain tumor segmentation from contrast-enhanced T1-weighted MRI remains challenging because of heterogeneous tumor appearance and complex boundaries. This study proposes HSegFormer, a hybrid CNN–Transformer architecture that combines convolutional feature extraction with transformer-based contextual modeling, attention-guided decoding, and deep supervision. The model is trained…
Karunya A S, K. Sudeep Kumara, Avin Kumar, Kamalaksh Shenoy
Abstract Head and neck cancer (HNC), a heterogeneous group of malignancies that arising from the mucosal surfaces of the Upper Aerodigestive Tract (UADT), is a major health concern worldwide. By 2050, the number of cancer cases worldwide is expected to reach 35 million, with nearly half of all new cases and deaths occurring in Asia. In India, HNC is particularly prevalent accou…
Xuecong Wang, Cecilia Xi Zhang, Yi Zhao, Jianxing He et al.
Epithelial–mesenchymal transition (EMT), historically described as a binary morphological change from an epithelium to a mesenchymal state, no longer adequately accounts for carcinoma cell phenotypes observed in patients. Single-cell sequencing, spatial-omics, and lineage tracing converge on a different picture as carcinoma cells rarely undergo a unidirectional transition endin…
In survival analysis, addressing non-proportional hazards and the presence of long-term survivors poses substantial methodological challenges, as traditional models often fail to capture these features adequately. To overcome these limitations, a novel long-term survival model is proposed that integrates the Yang and Prentice framework with a defective Gompertz distribution. Th…
Colorectal cancer (CRC), one of the most common malignant tumors of the digestive system worldwide, shows an annual upward trend in its incidence and mortality, posing a serious threat to human health and life.In recent years, with the rapid development of immunotherapeutic drugs and the continuous optimization of CRC treatment strategies, breakthrough progress has been achieve…
Abstract Organic–inorganic hybrid nanomaterials constructed through supramolecular assembly have emerged as versatile platforms that integrate the dynamic functionalities of biomacromolecules with the distinctive physicochemical properties of inorganic components. In this Focus Review, the design principles and biomedical applications of hybrid nanosystems based on physically c…
Xianhong Shi, Beibei Wang, Xiaohui Zhao, Heng Li et al.
Crohn’s disease is a chronic inflammatory bowel disease that is closely associated with genetic factors, immune dysregulation and microbial imbalance. Lesions involving the oral cavity and upper gastrointestinal tract constitute a common yet clinically overlooked manifestation of this disease. This article reviews the cellular and molecular mechanisms underlying disease onset a…
Julian Swatler, Simone Puccio, Emanuele Voulaz, Giuseppe Marulli et al.
Abstract CD4 + CD25 + FOXP3 + regulatory T cells (Treg) are highly activated in tumors and promote disease progression. Specific, universal targeting of these effector Treg cells is limited by the lack of a conserved signature across human cancers and information on their origin. Here we combine analysis of single-cell RNA-sequencing datasets with spectral flow cytometry and id…
Yuhan Tang, Yingze Zhu, Shaochun Liu, Xiaoxi Han et al.
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) combined with endocrine therapy have become a therapeutic backbone for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, yet durable disease control is frequently limited by intrinsic and acquired resistance. Canonical tumor-cell mechanisms, including retinoblastoma-pathway …
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