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Therapeutic📖 Free full textPeer-ReviewedPubMedPractical radiation oncology · 2026

Exacerbation of focal hepatotoxicity with Axitinib after Stereotactic Body Radiotherapy (SBRT) to malignant Renal mass in close proximity to Liver and resolution after short term drug holiday: Possible radio-sensitization effect.

Bisht SS, Saini A, Gautam D, Kataria SP et al.

PurposeStereotactic Body Radiation Therapy (SBRT) has emerged as an effective treatment option for patients with Renal cell carcinoma (RCC). Studies have shown that Tyrosine Kinase Inhibitors (TKI) af…

TherapeuticQA & dosimetry📖 Free full textPeer-ReviewedPubMedMedical dosimetry : official journal of the American Association of Medical Dosimetrists · 2026

Dosimetric and radiobiological evaluation of a spatially fractionated core-boost strategy in lung metastases within 5 mm of the esophagus: Single-center plan-comparison study.

Suyusal İH, Çolak O, Karagöz AS.

For lung metastases lying within 5 mm of the esophagus, organ-at-risk dose limits often force the prescription below the ablative range, lowering biologically effective dose and tumor control. We eval…

QA & dosimetryTherapeutic📖 Free full textPeer-ReviewedOpenAlexJournal of Cancer Treatment and Research · 2026

Impact of DIBH Technique on Dosimetric Parameters of LAD and Its Segments During Left-Sided Breast Cancer Radiotherapy

M Meshram, Sameer Chandorkar, Himanshu Kumbhare, Arpit Gite et al.

Deep inspiration breath hold (DIBH) technique plays significant role in reducing the mean heart and LAD doses, however the potential dosimetric impact of DIBH on LAD segments has not been studied in l…

QA & dosimetry📖 Free full textPeer-ReviewedPubMedRadiation oncology (London, England) · 2026

How reliable is deep inspiration breath hold at CT simulation? Clinical impact of surface-guided breathing training in breast cancer radiotherapy.

Dietrich L, Lackner N, Karius A, Brand J et al.

Deep inspiration breath hold (DIBH) is widely used to reduce cardiac dose in left-sided breast radiotherapy. However, the reliability of DIBH at CT simulation, has not been systematically evaluated de…

Therapeutic📖 Free full textPeer-ReviewedPubMedRadiation oncology (London, England) · 2026

Clinical evaluation using first-day assessment of patient suitability for successful performance of deep inspiration breath-hold for breast cancer radiotherapy.

Cepni B, Batista V, Hoeltgen L, Waldsperger H et al.

Deep inspiration breath-hold (DIBH) is a radiotherapy standard technique for cardiac-sparing in breast cancer, particularly for left-sided tumors. However, not all patients can successfully complete D…

TherapeuticQA & dosimetry📖 Free full textPeer-ReviewedPubMedJournal of applied clinical medical physics · 2026

Dosimetric and radiobiological evaluations as well as technical aspects of left breast treatment employing DIBH with SGRT in radiotherapy with IMRT step and shoot, IMRT Dynamic MLC and VMAT.

Rolland J, Payan S, Fau P, Mailleux H et al.

BackgroundTreatment of the left breast using deep inspiration breath hold (DIBH), combined with surface guided radiotherapy (SGRT), has emerged as the standard for reducing the dose to the heart, the …

QA & dosimetryTherapeuticPeer-ReviewedPubMedPrecision radiation oncology · 2026

Normal tissue complication probability models of late cardiopulmonary toxicity following deep inspiration breath hold for breast cancer adjuvant radiotherapy.

Lin L, Liu L, Gao Z, Hong Y et al.

Background and purposeDeep inspiration breath hold (DIBH) is a respiratory control technique designed to minimize cardiopulmonary toxicity induced by adjuvant radiotherapy for left-sided breast cancer…

Therapeutic📖 Free full textPeer-ReviewedPreprint · 2026

Network Meta-Analysis of Cardiac, Coronary, and Pulmonary Dose-Sparing Effects of Different Deep-Inspiration Breath-Hold Techniques in Radiotherapy for Left-Sided Breast Cancer

Wu X, Wu P, Wang H, Zhang Y.

Abstract Background Deep-inspiration breath-hold (DIBH) can reduce cardiac, left anterior descending coronary artery (LAD), and ipsilateral lung exposure during radiotherapy for left-sided breast canc…

TherapeuticPeer-ReviewedPubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026

Linear screening and machine learning to identify suitable candidates for active breathing control after mastectomy in left-sided breast cancer.

Zheng C, Zhang J.

PurposeTo evaluate the dosimetric benefit of deep inspiration breath-hold (DIBH) using the Active Breathing Coordinator (ABC) for left-sided breast cancer radiotherapy and to identify patients most li…

TherapeuticPeer-ReviewedPubMedPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026

Comparison of heart-sparing efficacy between deep inspiration and end-expiration breath-hold in gastric MALT lymphoma radiotherapy: Spatial separation versus margin reduction.

Yang Q, Li W, Wang L, Sun Z et al.

This study aims to explore whether spatial separation in deep inspiration breath-hold (DIBH) or margin reduction in end-expiration breath-hold (EEBH) achieves heart-sparing efficacy in the radiotherap…

TherapeuticPeer-ReviewedPubMedPractical radiation oncology · 2026

Toxicity and Cosmetic Outcomes of 28 Gy in 5 Fractions Twice per Week Ultrahypofractionated Whole-Breast Irradiation in Early-Stage Breast Cancer.

Jitwatcharakomol T, Gokun Y, Young RL, Eckstein JM et al.

BackgroundThe UK FAST and FAST-Forward trials established the non-inferiority of ultrahypofractionated whole-breast irradiation delivered in five fractions with respect to local control, toxicity, and…

Therapeutic📖 Free full textPeer-ReviewedPubMedTechnical innovations & patient support in radiation oncology · 2026

Mechanically-assisted non-invasive deep inspiration breath-hold (MANIV-DIBH): A first clinical application in paediatric radiotherapy.

Audag N, Di Perri D, Razavi A, Quaresma SDR et al.

Background and purposeRespiratory motion is a major challenge in paediatric thoracic radiotherapy, where minimizing exposure to healthy tissues is essential to reduce long-term toxicity. Mechanically-…

Therapeutic📖 Free full textPeer-ReviewedPubMedBMC medical imaging · 2026

Deformable image registration accuracy: impact of user-defined parameter selection on contour propagation for deep inspiration breath-hold and free breathing breast radiotherapy.

Knippen S, Pargmann L, Weimann S, Hildebrandt G et al.

PurposeDeformable Image Registration (DIR) is increasingly used in breast radiotherapy planning, but the impact of different parameter settings on clinical accuracy remains unclear. This study systema…

Therapeutic📖 Free full textPeer-ReviewedPubMedClinical and translational radiation oncology · 2026

Continuous positive airway pressure in breast cancer radiotherapy: Protocol of a prospective clinical trial.

Van der Vorst A, Verhoeven J, Baten A, Janssen H et al.

BackgroundRadiotherapy (RT) improves survival and local control after breast-conserving surgery (BCS) for breast cancer (BC) but can also cause toxicity. Preliminary studies suggest that continuous po…

QA & dosimetryPeer-ReviewedPubMedThe British journal of radiology · 2026

Evaluation of patient setup accuracy using optical surface guidance in postoperative radiotherapy for patients with breast cancer after breast-conserving surgery.

Wan B, Han J, Zheng Y, Liu C et al.

ObjectivesTo evaluate the clinical application of AlignRT surface-guided radiotherapy (SGRT) by quantifying interfractional setup errors in patients with breast-conserving surgery (BCS) stratified by …

Therapeutic📖 Free full textPeer-ReviewedPubMedTechnical innovations & patient support in radiation oncology · 2026

Upright versus supine positioning for breast and lung radiotherapy: a pilot study on patient comfort, experience and lung function.

Boisbouvier S, Criscuolo A, Underwood T, Grégoire V.

Delivering radiotherapy in upright body positions (UP) may offer advantages for breast and lung cancer treatments due to physiological/anatomical differences compared to the supine position (SP), as w…

TherapeuticPeer-ReviewedPubMedThe British journal of radiology · 2026

MRI-based analysis of organ at risk stability during prolonged voluntary deep inspiration breath-hold in prone and supine breast cancer radiotherapy.

Huybrechts V, Vakaet V, De Noyette R, Speleers B et al.

ObjectivesDeep inspiration breath-hold (DIBH) is commonly used in breast cancer radiotherapy to reduce radiation exposure to the heart and lungs. Recent techniques incorporating oxygen supplementation…

TherapeuticPeer-ReviewedPubMedPhysical and engineering sciences in medicine · 2026

Comparison of surface-guided radiotherapy-based deep inspiration breath hold and continuous positive airway pressure techniques in left-sided breast cancer: dosimetric and workflow analysis.

Han SC, Lee JJB, Cho JD, Jeong IS et al.

This study aimed to compare the clinical utility of two respiratory motion management techniques—deep inspiration breath hold (DIBH) and continuous positive airway pressure (CPAP)—both integrated with…

Therapeutic📖 Free full textPeer-ReviewedPubMedJournal of personalized medicine · 2026

Alternative Treatment Positions over Supine in Adjuvant Whole Breast RT: Prone, Lateral or What Else? A Comprehensive Narrative Review.

Benevento I, Solazzo A, Rago L, Montagna A et al.

Whole breast radiotherapy in adjuvant breast cancer (BC) treatment has been commonly delivered in supine positioning for more than 50 years. Its widespread use is related to the broad availability of …

Therapeutic📖 Free full textPeer-ReviewedPubMedRadiation oncology (London, England) · 2026

Dosimetric advantages and clinical feasibility of a novel lateral decubitus position for left breast cancer patients undergoing PORT.

Zhou Y, Xu J, Deng Y, Pan L et al.

BACKGROUND: Radiation-induced cardiac toxicity remains a significant concern in breast cancer radiotherapy. Our institution developed a novel lateral decubitus position (nLDP) technique for patients u…

Therapeutic📖 Free full textPeer-ReviewedPubMedCureus · 2026

A Comprehensive Evaluation of Setup Uncertainties and Margin Optimization Using Deep Inspiration Breath-Hold Versus Free-Breathing Techniques in Breast Carcinoma.

Sivasamy J, Jayaraman I, Anbazhagan SK, Alagarsamy V.

PurposeTo systematically evaluate and compare geometric setup errors and calculate optimal planning target volume (PTV) margins for patients with left-sided breast carcinoma treated with three-dimensi…

QA & dosimetry📖 Free full textPeer-ReviewedPubMedJournal of applied clinical medical physics · 2026

Daily quality assurance, system and procedure-specific commissioning of a bore-based optical surface imaging system for surface-guided radiotherapy (SGRT).

Li G, Liu X, Donahue W, Lin SC et al.

PurposeThis study aimed to commission the AlignRT inBore system in Ethos/Halcyon linear accelerator (Linac) systems for surface-guided radiotherapy (SGRT), including developing a soft collision qualit…

Therapeutic📖 Free full textPeer-ReviewedPubMedCureus · 2026

Dosimetric Comparison of Deep Inspiration Breath-Hold and Free-Breathing Techniques in Stereotactic Body Radiotherapy for Localized Lung Tumors at a Tertiary Care Center.

Arora S, Sathyanarayanan MS, Kajamohideen S, Chilukuri S et al.

Background Respiratory motion is a major source of geometric uncertainty in lung stereotactic body radiotherapy (SBRT) and may lead to increased irradiation of normal lung tissue and adjacent organs a…

Therapeutic📖 Free full textPeer-ReviewedPubMedTechnical innovations & patient support in radiation oncology · 2026

Impact of variation in voluntary moderate deep inspiration breath hold on the 3D dose distribution in breast cancer radiotherapy.

van der Werf L, Murrer L, Verhoeven K, Knarren D et al.

AimDetermination of impact of variations during voluntary moderately deep inspiration breath hold (vmDIBH) on doses to organs at risk (OAR) and target coverage in patients undergoing radiotherapy (RT)…

TherapeuticPeer-ReviewedPubMedRadiography (London, England · 2026

Identification of selection criteria for DIBH in patients with left breast cancer using 3D-CRT and VMAT: An analysis with dosimetric parameters and NTCP models.

Ayouni H, Zarraa S, Daoud B, Saidi S et al.

IntroductionDeep-inspiration breath-hold (DIBH) is a well-established technique for sparing organs-at-risk in breast cancer (BC) radiotherapy. Nonetheless, consensus on who benefits most remains elusi…

Therapeutic📖 Free full textPeer-ReviewedPubMedBJR case reports · 2025

Navigating technical hurdles: implementing a tailored Vac-Lok prone pillow technique to optimize radiotherapy in a case of large pendulous breast.

Nair P, Sasidharan A, Kalavagunta S, Bhaskaran P et al.

Breast radiotherapy, typically administered using tangential fields in the supine position, employs various strategies to improve dose uniformity and minimize radiation exposure to sensitive organs. H…

QA & dosimetry📖 Free full textPeer-ReviewedPubMedRadiation oncology (London, England) · 2024

Study protocol: Optimising patient positioning for the planning of accelerated partial breast radiotherapy for the integrated magnetic resonance linear accelerator: OPRAH MRL.

Dean J, Anderson N, Halkett GKB, Lye J et al.

BackgroundAccelerated partial breast irradiation (APBI) is an accepted treatment option for early breast cancer. Treatment delivered on the Magnetic Resonance integrated Linear Accelerator (MRL) provi…

QA & dosimetry📖 Free full textCited 184×Peer-ReviewedPubMedMedical physics · 2022

AAPM task group report 302: Surface-guided radiotherapy.

Al-Hallaq HA, Cerviño L, Gutierrez AN, Havnen-Smith A et al.

The clinical use of surface imaging has increased dramatically, with demonstrated utility for initial patient positioning, real-time motion monitoring, and beam gating in a variety of anatomical sites…

Therapeutic📖 Free full textCited 54×Peer-ReviewedPubMedRadiation oncology (London, England) · 2021

Deep-inspirational breath-hold (DIBH) technique in left-sided breast cancer: various aspects of clinical utility.

Gaál S, Kahán Z, Paczona V, Kószó R et al.

BackgroundStudying the clinical utility of deep-inspirational breath-hold (DIBH) in left breast cancer radiotherapy (RT) was aimed at focusing on dosimetry and feasibility aspects.MethodsIn this prosp…

QA & dosimetry📖 Free full textCited 5×Peer-ReviewedPubMedTechnology in cancer research & treatment · 2021

Compare of Interfractional Setup Reproducibility Between Vacuum-Lock Bag and Thermoplastic Mask in Radiotherapy for Breast Cancer.

Song Y, Peng J, Chen Q, Luo H.

Background: This study aimed to analyze the difference of setup reproducibility between Vacuum-lock bag and Thermoplastic mask in the radiotherapy for breast cancer. Methods: A total of 100 invasive b…

QA & dosimetry📖 Free full textCited 118×Peer-ReviewedPubMedRadiation oncology (London, England) · 2020

Recent advanced in Surface Guided Radiation Therapy.

Freislederer P, Kügele M, Öllers M, Swinnen A et al.

The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. A…

Therapeutic📖 Free full textCited 51×Peer-ReviewedPubMedRadiation oncology (London, England) · 2019

Left breast irradiation with tangential intensity modulated radiotherapy (t-IMRT) versus tangential volumetric modulated arc therapy (t-VMAT): trade-offs between secondary cancer induction risk and optimal target coverage.

Karpf D, Sakka M, Metzger M, Grabenbauer GG.

BackgroundAdjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and the…

TherapeuticCited 84×Peer-ReviewedPubMedStrahlentherapie und Onkologie · 2019

Heart-sparing radiotherapy techniques in breast cancer patients: a recommendation of the breast cancer expert panel of the German society of radiation oncology (DEGRO).

Duma MN, Baumann R, Budach W, Dunst J et al.

PurposeThe aim of this review was to analyze the respective efficacy of various heart-sparing radiotherapy techniques.Material and methodsHeart-sparing can be performed in three different ways in brea…

QA & dosimetry📖 Free full textCited 51×Peer-ReviewedPubMedRadiation oncology (London, England) · 2019

Evaluation of a 3D surface imaging system for deep inspiration breath-hold patient positioning and intra-fraction monitoring.

Hamming VC, Visser C, Batin E, McDermott LN et al.

PurposeTo determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Seco…

TherapeuticCited 71×Peer-ReviewedPubMedRadiotherapy and oncology · 2019

Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy.

Simonetto C, Eidemüller M, Gaasch A, Pazos M et al.

PurposeAim of the current comparative modelling study was to estimate the individual radiation-induced risk for death of ischaemic heart disease (IHD) under free breathing (FB) and deep inspiration br…

TherapeuticCited 67×Peer-ReviewedPubMedStrahlentherapie und Onkologie · 2018

Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease : Effects of modern radiotherapy techniques.

Corradini S, Ballhausen H, Weingandt H, Freislederer P et al.

PurposeModern breast cancer radiotherapy techniques, such as respiratory-gated radiotherapy in deep-inspiration breath-hold (DIBH) or volumetric-modulated arc radiotherapy (VMAT) have been shown to re…

QA & dosimetry📖 Free full textCited 85×Peer-ReviewedPubMedRadiation oncology (London, England) · 2016

Treatment planning and evaluation of gated radiotherapy in left-sided breast cancer patients using the CatalystTM/SentinelTM system for deep inspiration breath-hold (DIBH).

Schönecker S, Walter F, Freislederer P, Marisch C et al.

BackgroundThere is a potential for adverse cardiovascular effects in long-term breast cancer survivors following adjuvant radiotherapy (RT). For this purpose, the deep inspiration breath-hold techniqu…

Therapeutic📖 Free full textCited 74×Peer-ReviewedPubMedRadiation oncology (London, England) · 2015

Cardiac dose reduction with deep inspiration breath hold for left-sided breast cancer radiotherapy patients with and without regional nodal irradiation.

Yeung R, Conroy L, Long K, Walrath D et al.

BackgroundDeep inspiration breath hold (DIBH) reduces heart and left anterior descending artery (LAD) dose during left-sided breast radiation therapy (RT); however there is limited information about w…

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