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Knowledge Hub · Division

Onco Surgery

Intra-operative gamma-guided probes and fluorescence-imaging systems for radioguided oncological surgery. 4 evidence libraries live below.

OS-001Distributed in India by Saxsons Healthcare

Europrobe™ 3.2 Gamma Detection System

Handheld intraoperative gamma-detection platform — one console + 28+ probe models across CdTe and CsI(Tl) scintillators. Six peer-reviewed anchor citations: Krag 2010 NSABP B-32 (Lancet Oncol · 5 611-woman breast-SLN RCT), Morton 2014 MSLT-I (NEJM · melanoma), Faries 2017 MSLT-II (NEJM · completion LND vs observation), Van der Zee 2008 GROINSS-V (JCO · vulvar), Ballester 2011 SENTI-ENDO (Lancet Oncol · endometrial), Radnia 2021 (Ann Nucl Med · NEMA NU3-2004 benchmark).

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6 Landmark RCTsNEMA NU3-2004CE 0459 · FDA
6 peer-reviewed anchor citations
NSABP B-32 · MSLT-I · MSLT-II · GROINSS-V · SENTI-ENDO
NEMA NU3-2004 characterisation benchmark
Breast / melanoma / gynae / ENT / uro SLN
OS-004Distributed in India by Saxsons Healthcare

Europrobe™ Gamma + Fluorescence

World-first single dual-channel probe — CdTe gamma + ICG NIR fluorescence detection in the same probe body. Six peer-reviewed anchor citations: Van der Vorst 2012 (Ann Surg Oncol · foundational NIR + Tc-99m breast RCT), Schaafsma 2013 (Br J Surg · 48/48 combined vs 42/48 blue dye), Vreeburg 2023 (EJNMMI · hybrid-tracer choice), Gâta 2025 (Med Sci · 476-patient modern breast comparison), Wölffer 2024 (Cancers · melanoma ICG depth-ceiling meta-analysis), Brouwer 2014 (EJNMMI · dual-probe characterisation).

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6 Peer-Reviewed CitationsDual-ModalityEU MDR Class IIa
6 open-access anchor citations
48/48 combined gamma+NIR vs blue-dye 42/48
Hybrid ICG-99mTc-nanocolloid tracer workflow
Depth-ceiling boundary vs surface NIR camera
OS-002Radioactive Seed Localisation (RSL) evidence library

I-125 Tumour Localisation Seed

Low-dose ¹²⁵I titanium-encapsulated sealed-source seed for image-guided non-palpable breast-lesion + soft-tissue-mass localisation. Four peer-reviewed anchor citations: Taylor 2021 (BJS · multicentre RCT · 13.9 % vs 18.9 % re-excision vs hookwire), Ferreira 2024 (Diagnostics · meta-analysis · 19 820 women · RR 0.78 positive margin), Miodownik 2024 (J Radiol Prot · 25 722-seed Memorial Sloan Kettering safety cohort · 0.027 % loss rate) and Kuo 2016 (Skeletal Radiology · non-palpable soft-tissue-mass extension).

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RCT-Grade EvidenceAAPM TG-43U1Wire-Free
4 peer-reviewed anchor citations
Multicentre RCT · 659 women
25 722-seed safety cohort
Sarcoma / soft-tissue extension
OS-003 · FamilyDetector-material selection library

Intraoperative Gamma Probes · CdTe + CsI(Tl) Family

Family knowledge hub — CdTe / CdZnTe semiconductor vs CsI(Tl) + APD scintillator trade-off (spatial + energy resolution vs raw sensitivity), NEMA NU3-2004 characterisation (Radnia 2021), breast SLNB gamma vs ICG (Gâta 2025 · 476 patients), melanoma ICG depth ceiling (Wölffer 2024 meta-analysis · 1-2 cm limit), combined gamma + NIR hybrid tracer (Schaafsma 2013 · Br J Surg · 48/48 vs blue-dye 42/48) and recurrent-thyroid revision surgery (Gültekin 2013).

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CdTe vs CsI(Tl)NEMA NU3-2004vs ICG NIR
6 peer-reviewed anchor citations
Detector-material selection guide
Depth-limit boundary vs ICG NIR
SLNB / ROLL / parathyroid / thyroid revision