Radiotherapy QA · Literature Radar
Intracranial SRS — single-iso multi-met, frame-vs-frameless, rotational-correction studies. Curated daily from Europe PMC (PubMed + PMC + preprints) and OpenAlex — free-full-text link on each open-access paper.
Yock AD, Luo G, All S, Kirschner AN et al.
BackgroundTreating multiple brain metastases simultaneously with single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS) can streamline treatment planning and delivery. However, it can al…
Reyes JS, Hadjipanayis CG, Niranjan A.
We developed THINKERS-X: Lung, the eXtended multimodal evolution of THINKERS-Lung, to determine whether multisequence MRI radiomics provides incremental value for lesion-specific outcome prediction an…
Alswaiti Y, Shahwan G, Alhayek B, Absi S et al.
PurposeStereotactic radiosurgery (SRS) is the treatment of choice for limited brain metastases (BM), and its combination with PD-1/PD-L1 inhibitors is hypothesized to offer synergistic therapeutic ben…
Ho A, Yadav P, Sonabend A, Tate M et al.
PurposeWhole-brain radiotherapy (WBRT) is commonly used for patients with a high burden of brain metastases (BM), but its well-documented toxicity profile raises concerns. Initial results from a pivot…
Utitsarn K, Watthanasarn T, Chaloemchawalit W, Krongkietlearts K.
Stereotactic radiosurgery delivers an ablative single-fraction dose to small intracranial targets, and the reported dose depends on the calculation algorithm. This exploratory case series quantified t…
Balasubramanian S, Anbalagan D, Thanasekar P, Agrawal R.
Our study aimed to perform a comprehensive end-to-end (E2E) dosimetric and geometric evaluation of the newly commissioned Varian Edge linear accelerator (LINAC) with the HyperArc™ VMAT system for mult…
Bales TR, Hernandez-Rovira MA, Pasupuleti CKA, Prabhu KN et al.
Background and objectivesRadiation-induced meningiomas (RIMs) are the most common secondary intracranial tumors. Compared with sporadic meningiomas (SMs), RIMs exhibit more aggressive clinical behavio…
Rajkumar S, Moy H, Ji X, Aboian M et al.
PurposeStereotactic radiosurgery (SRS) effectively treats brain metastases, yet some lesions ultimately require post-SRS surgery due to local failure. We examined whether the use of volumetric changes…
Sahin S, Ceylan C, Göksel EO, Özen Z.
This study aimed to characterize the response and inter-system consistency of a high-resolution myQA SRS detector used for patient-specific quality assurance (PSQA) across different configurations of …
Sutanto R, Muljadi R, Hakim AHW, Octavius GS.
IntroductionEpstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal neoplasm occurring predominantly in immunocompromised individuals, with central nervous system involvement…
Koketsu Y, Hasegawa T, Kato T, Naito T et al.
PurposeTo evaluate dose selection and post-treatment management after Gamma Knife surgery (GKS) for large brain metastases, with a focus on early identification of true progression.MethodsThis retrosp…
El Basha D, Filiput E, Curcuru A, Ferguson S et al.
BackgroundGamma Knife radiosurgery (GKRS) has been a foundational modality for the treatment of intracranial diseases for several decades, with successive platform generations introducing substantial …
McMahon DJ, John A, Ketpueak T, De Boisanger J et al.
ObjectivesApproximately 60% of patients with small cell lung cancer (SCLC) develop brain metastases (BM). Historically these have been managed with whole brain radiotherapy. We sought to compare outco…
Stasinou D, Platoni K, Margaroni V, Zourari K et al.
BackgroundSingle-isocenter stereotactic radiosurgery enables efficient treatment of multiple brain metastases (SI-MBM SRS), but demands high geometric accuracy. Plan complexity metrics are increasingl…
Ampil F, Brown R, Norton M.
Background/aimHippocampal brain metastases are uncommon, and evidence regarding their management and outcomes remains limited. This study evaluated the efficacy and safety of whole-brain radiotherapy …
Tamura M, Nishimura Y, Matsuura T, Inosaka Y et al.
BackgroundA new preconfigured CyberKnife system was introduced to improve the SRS/SBRT commissioning efficiency. The vendor provides a reference beam data set, termed "beam data model (BDM)", and reco…
Gui B, Sekar J, Locke M, Saha S et al.
Purpose/objectivesRecurrent and metastatic non-anaplastic thyroid cancer has traditionally been considered relatively radioresistant. We evaluated whether anatomic site or histology risk group better …
Järvelin P, Pekonen H, Koivisto T, Frösen J.
BackgroundSpetzler-Martin (SM) grade III arteriovenous malformations of the brain (bAVMs) represent a clinical gray area with no definitive treatment guidelines. It is not well established whether cas…
Aytehgeza RS, McClelland S.
ObjectivesStereotactic radiosurgery (SRS) treats intracranial tumors during pregnancy when intervention cannot be delayed until delivery. However, fetal radiation exposure raises toxicity and carcinog…
Pogue JA, Cardan R, Li FR, Sullivan R et al.
Automated stereotactic radiosurgery (SRS) planning produced consistent dose falloff, enabling adverse-effect-relevant isodose volumes ( IDV ) to be estimated before plan generation. We derived a direc…
Pham QV, Pham QT.
This study aims to develop and evaluate the performance of Collimator Angles Optimization Software version 2 (CAOS-v2) for stereotactic radiosurgery (SRS) planning in patients with multiple brain meta…
Shinya Y, Lee DH, Hori YS, Lam FC et al.
Surgically inoperable cerebral arteriovenous malformations (AVMs), including deep-seated, large, and eloquently located lesions, remain difficult to manage because the cumulative risk of hemorrhage mu…
Udovicich C, Tseng CL, Detsky J, Chen H et al.
PurposeTo evaluate the efficacy and safety of salvage conventionally fractionated Gamma Knife stereotactic radiotherapy (SFGK) reirradiation for recurrent, previously irradiated primary non-glial brai…
Opalko E, Prasad D, Podgorsak M.
Liu X, Ma B, Yang M, Zhao L.
Guo X, Wang K, Shi S, Wang L et al.
Koizumi S, Umekawa M, Shinya Y, Hasegawa H et al.
Brain arteriovenous malformations (AVMs) with high-risk angioarchitecture features are associated with the risk of hemorrhage. This study evaluated the safety and effectiveness of a combined approach …
Zhuang X, Lu X, Miao J, Hou G et al.
The optimal timing for integrating stereotactic radiosurgery (SRS) with first-line osimertinib in EGFR-mutant non-small cell lung cancer (NSCLC) with brain metastases (BMs) is undefined. The present s…
Sehrawat K, Polley MC, Vogelbaum MA, Gilbert M et al.
Radiation Therapy Oncology Group (RTOG) and NRG Oncology have played a key role in shaping evidence-based management of central nervous system (CNS) tumors. These have defined standards for radiothera…
Kattaa AH, Harary P, Voruganti H, Lee I et al.
Abstract BACKGROUND And OBJECTIVES Facial nerve schwannomas (FNS) are rare benign tumors requiring a balance between tumor control and facial nerve preservation. Treatment options include open surgica…
Adhamidhis E, Srisaikaew P, Li J, Latypov TH et al.
Background/Objectives: Trigeminal neuralgia (TN) is a severe chronic neuropathic facial pain condition. Although TN can be amenable to surgical treatments, ~25% of patients may have recurrence of pain…
Gadam RK, Stepp TE, Jiang H, Bhargav A et al.
PurposeLarge cerebral arteriovenous malformations (AVMs) pose significant management challenges, particularly in achieving complete nidus obliteration without increasing the risk of symptomatic necros…
Chen T, Chaga M, Feng W, Wang T et al.
Jheremy S. Reyes, Ajay Niranjan, Constantinos G. Hadjipanayis
Background Prescription dose selection for breast cancer brain metastases treated with stereotactic radiosurgery remains largely guided by tumor size, anatomical constraints, and institutional practic…
Lewis D, Millman RE, Whiston H, Hannan CJ et al.
There is a need for a definitive RCT comparing upfront stereotactic radiosurgery (SRS) versus watch-and-wait (WW) for long-term hearing preservation in vestibular schwannoma (VS). Specific objectives …
Mastella E, Szilagyi KE, Perrine JS, Ferioli M et al.
Accurate dose verification is essential in stereotactic radiosurgery (SRS), where small fields and steep dose gradients may amplify uncertainties, especially with complex techniques like multitarget s…
Rahim Li F, Cardan RA, Pogue JA, Viscariello NN et al.
Accurate modeling of multi-leaf collimators is critical for dose calculation in stereotactic radiosurgery (SRS), where steep dose gradients and small target volumes amplify modeling uncertainties. Thi…
Jesus Antonio Rodriguez Santos, Jennifer De Alas, Eduardo E Lovo
Trigeminal neuralgia arising from an intracranial tumor is uncommon but therapeutically distinctive because the responsible lesion is simultaneously the generator of facial pain and an independent onc…
Mehmet Fazil Enkavi, Hasan Uysal, Kaan Oysul, Sait Şirin et al.
OBJECTIVE: To develop a high-spatial-resolution Cherenkov-excited fluorescence dosimetry system (CEFD) with rapid optical readout using quinine sulfate solution and evaluate its feasibility for small-…
Duzkalir AH, Askeroglu MO, Yildirim DC, Marciniuk K et al.
Brain metastases (BMs) from male breast cancer (MBC) are exceptionally rare, and the efficacy and safety of stereotactic radiosurgery (SRS) in this population remain poorly characterized. We conducted…
Harary PM, Hori YS, Tan SK, Mahaney K et al.
Embryonal tumors with multilayered rosettes (ETMR) are aggressive grade IV brain tumors primarily affecting children under age 3. Despite intensive multimodal therapy, prognosis remains poor, and salv…
Kattaa AH, Persad AR, Harary PM, Kassu R et al.
Background and objectivesThe thalamus, a neural processor and integrator for forebrain activities, is an uncommon site for metastatic lesions. Stereotactic radiosurgery (SRS) has become a noninvasive …
García-García VA, Ramírez-Sánchez MV, García-Romero RC, Jasso-García I et al.
BackgroundEpilepsy is a neurological disorder affecting over 50 million people worldwide, with a global incidence of 7.6 per 1,000 individuals. Mesial temporal lobe epilepsy (MTLE) is characterized by…
Shariati A, Khezrpour A, Fanihagh T, Fazel AE et al.
Postoperative stereotactic radiotherapy (SRT) is widely used after resection of limited brain metastases, but the optimal fractionation remains uncertain. Single-fraction stereotactic radiosurgery (SF…
Sarfraz Z, Kotecha R, Maharaj A, Ahluwalia MS.
Brain metastases (BM) are a common and clinically significant manifestation of advanced cancer that increasingly influences treatment decisions across solid tumors. Management requires a tailored appr…
Duzkalir AH, Duzkalir HG, Yildirim DC, Askeroglu MO et al.
ObjectiveGamma Knife radiosurgery (GKRS) for trigeminal neuralgia (TN) requires millimeter-scale accuracy because a single 4-mm collimator targets the cisternal trigeminal nerve (CTN). MRI is essentia…
Reyes JS, Hadjipanayis CG, Lunsford LD, Niranjan A.
Brain metastases from gastrointestinal (GI) malignancies are heterogeneous, while stereotactic radiosurgery dose selection remains guided by lesion size, location, prior treatment, and physician judgm…
Liu P, Zhao L, Liu G, Cong X et al.
Proton arc (PAT) therapy combines the dosimetric advantages of protons with the efficiency of arc delivery, but current planning algorithms are based on a static delivery sequence. The discrepancy bet…
Zhang K, Wang H, Shen L, Li M et al.
This study aimed to evaluate the beam data of Elekta stereotactic radiosurgery (SRS) cone collimators for 6MV and 6MV flattening filter-free (6MVFFF) beams and to assess the feasibility of implementin…
Qiang Z, Bragg C, Yianni J.
IntroductionDeep brain stimulation (DBS) is an established therapy for medically intractable movement disorders but poor response or habituation may prompt noninvasive salvage strategies. Stereotactic…
Umekawa M, Shinya Y, Hasegawa H, Miyawaki S et al.
Liu P, Zhao L, Cong X, Liu G et al.
Spot scanning proton arc therapy (SPArc) combines the dosimetric advantages of proton therapy with the beam-angle freedom of arc delivery. However, current planning algorithms rely on static delivery …
Robinson A, Caldwell MR.
BackgroundFrameless thermoplastic masks are standard for intracranial stereotactic radiosurgery (SRS), with the Encompass (CQ Medical) widely used on the Varian HyperArc platform. A candidate mask mus…
Park JE, Shao G, Baisiwala S, Kim N et al.
PurposeDifferentiating tumor recurrence from radiation necrosis (RN) after stereotactic radiosurgery (SRS) remains a major diagnostic challenge in brain metastasis. We aimed to validate established MR…
Alattar AA, Bartek J, Lin A, Chuck C et al.
FLAIR hyperintensity extending beyond a cerebral quadrant (FEQ+) after stereotactic radiosurgery (SRS) for brain metastases (BM) was a recently established imaging biomarker for steroid-dependent adve…
Reyes JS, Bouras A, Zureick AH, Lunsford LD et al.
BackgroundTime to local failure after stereotactic radiosurgery (SRS), including Gamma Knife radiosurgery (GKRS), for gastrointestinal (GI) brain metastases is difficult to predict and may vary substa…
Harriet Hebbes, Sara Walters, Patrick Forster, Jillian Maclean et al.
Abstract Introduction Metastatic non-small cell lung cancer (NSCLC) with synchronous brain metastases (BM) impacts prognosis and therapeutic considerations. Up to 20% patients with NSCLC may develop B…
Flavio Donnini, Giovanni Rubino, Giuseppe Battaglia, Pierpaolo Pastina et al.
Vestibular schwannoma (VS) care is increasingly shaped by molecular and imaging advances that complement conventional size- and symptom-based decision-making. Recent multi-omic studies, including sing…
Reyes JS, Bouras A, Lunsford LD, Hadjipanayis CG et al.
Prescription dose selection for lung brain metastases treated with stereotactic radiosurgery (SRS) remains largely guided by generalized practice patterns rather than tumor-specific modeling of local …
Ucar EA, Almas F, Senturk YE, Duzkalir AH et al.
Diffusion tensor imaging (DTI) has increasingly been incorporated into stereotactic radiosurgery (SRS) to improve visualization of eloquent neural pathways and to evaluate treatment-related microstruc…
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